4-iodo-2-Methyl-benzoic acid Methyl ester
Uses- Product Name
- 4-iodo-2-Methyl-benzoic acid Methyl ester
- CAS No.
- 103440-53-5
- Chemical Name
- 4-iodo-2-Methyl-benzoic acid Methyl ester
- Synonyms
- Methyl 4-iodo-2-Methylbenzoate;4-iodo-2-Methyl-benzoic acid Methyl ester;Benzoic acid, 4-iodo-2-methyl-, methyl ester
- CBNumber
- CB92645367
- Molecular Formula
- C9H9IO2
- Formula Weight
- 276.07
- MOL File
- 103440-53-5.mol
4-iodo-2-Methyl-benzoic acid Methyl ester Property
- Boiling point:
- 155 °C(Press: 17 Torr)
- Density
- 1.666±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M262748
- Product name
- Methyl4-Iodo-2-methylbenzoate
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- AK-77363
- Product name
- Methyl4-iodo-2-methylbenzoate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 149614
- Product name
- Methyl 4-iodo-2-methylbenzoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 0826AA
- Product name
- Methyl4-iodo-2-methylbenzoate
- Packaging
- 1g
- Price
- $187
- Updated
- 2021/12/16
- Product number
- AK-77363
- Product name
- Methyl4-iodo-2-methylbenzoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $364
- Updated
- 2021/12/16
4-iodo-2-Methyl-benzoic acid Methyl ester Chemical Properties,Usage,Production
Uses
Methyl 4-iodo-2-methylbenzoate is an organic intermediate that can be prepared by diazotization followed by iodination of methyl 4-amino-2-methylbenzoate or by direct esterification of 4-iodo-2-methylbenzoic acid.
Synthesis
67-56-1
133232-58-3
103440-53-5
To a solution of 4-iodo-2-methylbenzoic acid (2 g, 7.62 mmol) in methanol (20 mL) at 0 °C was slowly added thionyl chloride (1.5 mL, 10.87 mmol). The reaction mixture was heated to reflux and stirred for 6 hours. Upon completion of the reaction, the solvent was removed by distillation and the residue was diluted with ethyl acetate (50 mL). The organic phase was washed sequentially with water (100 mL) and sodium bicarbonate solution (50 mL) and then dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: 10% ethyl acetate in hexane solution) to afford methyl 4-iodo-2-methylbenzoate (1.8 g, 6.55 mmol, 85.7% yield) as a brown oily liquid.
References
[1] Patent: WO2016/154241, 2016, A1. Location in patent: Paragraph 560; 561
[2] Patent: US2005/143348, 2005, A1. Location in patent: Page/Page column 51
4-iodo-2-Methyl-benzoic acid Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-iodo-2-Methyl-benzoic acid Methyl ester manufacturers
- Product
- 4-iodo-2-Methyl-benzoic acid Methyl ester 103440-53-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14