METHYL 4-IODO-3-NITROBENZOATE
- Product Name
- METHYL 4-IODO-3-NITROBENZOATE
- CAS No.
- 89976-27-2
- Chemical Name
- METHYL 4-IODO-3-NITROBENZOATE
- Synonyms
- METHYL 4-IODO-3-NITROBENZOATE;4-iodo-3-nitrobenzoic acid methyl ester;Benzoic acid, 4-iodo-3-nitro-, methyl ester;Methyl-4-iodo-3-nitrobenzoate SynonyMs 4-Iodo-3-Nitrobenzoic Acid Methyl Ester
- CBNumber
- CB5256646
- Molecular Formula
- C8H6INO4
- Formula Weight
- 307.04
- MOL File
- 89976-27-2.mol
METHYL 4-IODO-3-NITROBENZOATE Property
- Melting point:
- 103-105°C
- Boiling point:
- 360.1±32.0 °C(Predicted)
- Density
- 1.904±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Yellow to brown Solid
- Water Solubility
- Soluble in DCM 10mg/0.5mL. Insoluble in water.
- Sensitive
- Light Sensitive
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M321628
- Product name
- Methyl4-Iodo-3-nitrobenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M321628
- Product name
- Methyl4-Iodo-3-nitrobenzoate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J96288
- Product name
- Methyl4-iodo-3-nitrobenzoate
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- Z5306
- Product name
- Methyl4-iodo-3-nitrobenzoate
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 4654-H-12
- Product name
- Methyl 4-iodo-3-nitrobenzoate
- Packaging
- 25g
- Price
- $408
- Updated
- 2021/12/16
METHYL 4-IODO-3-NITROBENZOATE Chemical Properties,Usage,Production
Uses
Methyl 4-iodo-3-nitrobenzoate is used as pharmaceutical intermediate.
Synthesis
67-56-1
35674-27-2
89976-27-2
Example 1: General procedure for the preparation of methyl 4-iodo-3-nitrobenzoate using methanol/sulfuric acid 1. dissolve 4-iodo-3-nitrobenzoic acid (3 g, 10 mmol) in methanol (30 ml) and cool the solution to 0°C. 2. sulfuric acid (3.4 g, 34.6 mmol) was added slowly to the above cooled solution. 3. the reaction mixture was gradually warmed to room temperature and subsequently heated to reflux (about 70 °C) and maintained for 8 hours. 4. Upon completion of the reaction, the reaction mixture was cooled and neutralized to pH neutral with solid NaHCO3 and filtered to remove the resulting salt. 5. The filtrate was concentrated under pressure to give a crude product. 6. Water (30 ml) was added to the crude product and extracted with methyl tertiary butyl ether (MTBE, 30 ml x 2). 7. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered. 8. The solvent was evaporated under pressure to give methyl 4-iodo-3-nitrobenzoate as a yellow solid (2.67 g, 85% yield, 98% HPLC purity).
References
[1] Dalton Transactions, 2015, vol. 44, # 5, p. 2047 - 2051
[2] Chemical Communications, 2017, vol. 53, # 55, p. 7808 - 7811
[3] Patent: US2013/172618, 2013, A1. Location in patent: Paragraph 0025
[4] Patent: WO2017/48954, 2017, A1. Location in patent: Paragraph 00095
[5] Patent: WO2005/40157, 2005, A2. Location in patent: Page/Page column 68
METHYL 4-IODO-3-NITROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 4-IODO-3-NITROBENZOATE manufacturers
- Product
- METHYL 4-IODO-3-NITROBENZOATE 89976-27-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-05