ChemicalBook > CAS DataBase List > (R)-2-Flurbiprofen

(R)-2-Flurbiprofen

Product Name
(R)-2-Flurbiprofen
CAS No.
51543-40-9
Chemical Name
(R)-2-Flurbiprofen
Synonyms
Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
CBNumber
CB8302496
Molecular Formula
C15H13FO2
Formula Weight
244.26
MOL File
51543-40-9.mol
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(R)-2-Flurbiprofen Property

Melting point:
110-113 °C(lit.)
Boiling point:
376.2±30.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml
form 
Crystalline Powder
pka
4.14±0.10(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70255
Product name
(R)-Flurbiprofen
Purity
≥99%
Packaging
100mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
70255
Product name
(R)-Flurbiprofen
Purity
≥99%
Packaging
1g
Price
$133
Updated
2024/03/01
Cayman Chemical
Product number
70255
Product name
(R)-Flurbiprofen
Purity
≥99%
Packaging
250mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
70255
Product name
(R)-Flurbiprofen
Purity
≥99%
Packaging
500mg
Price
$116
Updated
2024/03/01
TRC
Product number
F598730
Product name
(R)-Flurbiprofen
Packaging
250mg
Price
$140
Updated
2021/12/16
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(R)-2-Flurbiprofen Chemical Properties,Usage,Production

Description

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.

Uses

(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Definition

ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.

Biochem/physiol Actions

gamma secretase inhibitor; amyloid Abeta 42 lowering agent

(R)-2-Flurbiprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-2-Flurbiprofen Suppliers

Canada 1 China 155 Germany 1 India 7 Poland 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 8 United States 20 Global 197
AdooQ BioScience, LLC
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View Lastest Price from (R)-2-Flurbiprofen manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
(R)-2-Flurbiprofen 51543-40-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Hebei Mojin Biotechnology Co., Ltd
Product
(R)-2-Flurbiprofen 51543-40-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-11
Qiuxian Baitai New Material Co., LTD
Product
(R)-2-Flurbiprofen 51543-40-9
Price
US $90.00/KG
Min. Order
10KG
Purity
99.9%
Supply Ability
100tons
Release date
2021-10-29

51543-40-9, (R)-2-FlurbiprofenRelated Search:

Kresoxim-methyl Methylparaben Ethyl 2-(Chlorosulfonyl)acetate Biphenyl (Trifluoromethyl)trimethylsilane 2-Fluorophenylacetic acid 2-Phenylisobutyric acid Phenylmethylsulfonyl fluoride α-Lipoic Acid 4-Biphenylacetic acid Flurbiprofen 2-Methylbenzotrifluoride Bensulfuron methyl Methyl acrylate Trifluoromethanesulfonic anhydride 3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde Methyl

  • (R)-2-Fluoro-α-methyl-1,1'-biphenyl-4-acetic acid
  • (R)-α-Methyl-2-fluoro-1,1'-biphenyl-4-acetic acid
  • (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid (Flurbiprofe
  • [1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-Methyl-,(aR)-
  • Flurizan
  • MPC 7869
  • (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 97%
  • (R)-Flurbiprofen, >=99%
  • (R)-2-Flurbiprofenr
  • (R)-2-FLUBIPROFEN
  • (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID
  • (R)-(-)-FLURBIPROFEN
  • (R)-FLURBIPROFEN
  • E-7869
  • (R)-2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid
  • Flurbiprofene
  • (R)-(-)-2-Fluoro-α-methyl-4-biphenylacetic acid
  • (R)-2-Flurbiprofen
  • Furbiprofen
  • [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (R)-
  • [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αR)-　
  • l-Flurbiprofen
  • (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (FLURBIPROFEN)
  • E7869,Tarenflurbil,MPC7869
  • (R)-2-Flurbiprofen, Tarenflurbil
  • 2-Flurbiprofen
  • Tarenflurbil
  • (R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propionic acid
  • (R)-Flurbiprofen (E7869
  • Flurbiprofen CRS
  • (R)-FL
  • Flurbiprofen (R)-Isomer
  • (R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid
  • (R)-2-Flurbiprofen USP/EP/BP
  • (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic aci
  • R- Flurbiprofen-d4
  • (R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid
  • (-)-Flurbiprofen
  • (R)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid
  • 51543-40-9
  • 1543-40-9
  • Organic Building Blocks
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Carboxylic Acids
  • API
  • Pharmaceutical ingredients