ChemicalBook > CAS DataBase List > MEPENZOLATE BROMIDE

MEPENZOLATE BROMIDE

Product Name
MEPENZOLATE BROMIDE
CAS No.
76-90-4
Chemical Name
MEPENZOLATE BROMIDE
Synonyms
jb340;Colum;cantil;cantril;Delevil;Eftoron;Cantilon;NSC 4358;Colopiril;Trancolon
CBNumber
CB8305871
Molecular Formula
C21H26BrNO3
Formula Weight
420.34
MOL File
76-90-4.mol
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MEPENZOLATE BROMIDE Property

Melting point:
228-229°C dec.
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form 
Solid
color 
White to Off-White
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
TN5710000
Toxicity
LD50 orally in rats: 742±47 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M5651
Product name
Mepenzolate bromide
Purity
analytical standard
Packaging
5g
Price
$77.4
Updated
2024/03/01
Cayman Chemical
Product number
23717
Product name
Mepenzolate (bromide)
Purity
≥95%
Packaging
500mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23717
Product name
Mepenzolate (bromide)
Purity
≥95%
Packaging
1g
Price
$48
Updated
2024/03/01
TRC
Product number
M223750
Product name
Mepenzolate bromide
Packaging
5g
Price
$340
Updated
2021/12/16
Usbiological
Product number
M2908
Product name
Mepenzolate Bromide
Packaging
5g
Price
$403
Updated
2021/12/16
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MEPENZOLATE BROMIDE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Cantil,Merrell National,US,1956

Uses

Used as an anticholinergic

Definition

ChEBI: Mepenzolate bromide is a diarylmethane.

Manufacturing Process

A mixture containing 8 g (0.06 mol) of N-methyl-3-chloro-piperidine and 13.6 g (0.06 mol) of benzilic acid in 50 cc of anhydrous isopropyl alcohol was refluxed for 3 days; the isopropyl alcohol was removed by distillation in vacuo, the residue treated with dilute aqueous hydrochloric acid and the aqueous acid mixture extracted repeatedly with ether. The aqueous phase was separated, made strongly alkaline with 20% aqueous sodium hydroxide and extracted with ether. The ether extracts were dried with potassium carbonate and distilled; the product was collected at 175° to 176°C (0.03 mm), yield 11.5 g (59 %).The ester base thus prepared was then dissolved in 75 cc of isopropyl alcohol and 3.4 g (0.037 mol) methyl bromide added. The reaction mixture was allowed to stand at 30°C for 2 days and the product isolated by filtration, yield, 13 g (87%), MP 228° to 229°C dec.

Therapeutic Function

Spasmolytic

General Description

Mepenzolate bromide, 3-hydroxy-1,1-dimethylpiperidinium bromide benzilate (Cantil),has an activity about one half that of atropine in reducingACh-induced spasms of the guinea pig ileum. The selectiveaction on colonic hypermotility is said to relieve pain, cramps,and bloating and to help curb diarrhea.

Pharmacology

Mepenzolate inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used in place of other drugs for treating stomach ulcers and inflammation of the intestine. Synonyms of this drug are cantil and eftoron.

Synthesis

Mepenzolate, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl piperidinium bromide (14.1.13), is synthesized by esterification of benzilic acid with 1-methyl-3- chloropiperidine and subsequent reaction of the resulting ester (14.1.12) with methyl bromide [14,15].

MEPENZOLATE BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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MEPENZOLATE BROMIDE Suppliers

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View Lastest Price from MEPENZOLATE BROMIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
MEPENZOLATE BROMIDE 76-90-4
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-08-04
Career Henan Chemical Co
Product
(1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide 76-90-4
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

76-90-4, MEPENZOLATE BROMIDERelated Search:

2-(2-HYDROXYPHENYL)PROPIONIC ACID Methyl 2-hydroxyisobutyrate Methyl benzilate 2-Phenyl-1,2-propanediol (R)-(-)-2-HYDROXY-2-PHENYLPROPIONIC ACID ETHYL MANDELATE 2,2-Diphenylacetic acid BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE (S)-(+)-Methyl mandelate Clidinium bromide Butyl lactate Ethyl 2-hydroxyisobutyrate MEPENZOLATE BROMIDE METHACHOLINE BROMIDE ISOPROPYL (S)-(-)-LACTATE 3-METHOXYPIPERIDINE ETHYL (R)-(-)-MANDELATE L-(+)-MANDELIC ACID ETHYL ESTER

  • benzilicacid,1-methyl-3-piperidylestermethobromide
  • benzilicacid,esterwith3-hydroxy-1,1-dimethylpiperidiniumbromide
  • gastropidil
  • jb340
  • mepenzolate
  • n-methyl-3-piperidylbenzilatemethobromide
  • n-methyl-3-piperidylbenzilatemethylbromide
  • n-methyl-3-piperidyldiphenylglycolatemethobromide
  • piperidinium,3-hydroxy-1,1-dimethyl-,bromide,benzilate
  • (1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide
  • cantil
  • cantril
  • MEPENZOLATE BROMIDE
  • 3-[(HYDROXY-DIPHENYLACETYL)OXY]-1,1-DIMETHYLPIPERIDINIUM BROMIDE
  • 3-HYDROXY-1,1-DIMETHYLPIPERIDINIUM BROMIDE BENZILATE
  • 3-benziloyloxy-1,1-dimethylpiperidinium bromide
  • 1-Methyl-3-piperidyl benzilate methylbromide
  • 3-Hydroxy-1,1-dimethylpiperidinium bromide benzilate (6CI, 7CI)
  • Cantilaque
  • Cantilon
  • Colibantil
  • Colopiril
  • Colum
  • Delevil
  • NSC 4358
  • Piperidinium, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl-, bromide (9CI)
  • Piperidinium, 3-hydroxy-1,1-dimethyl-, bromide, benzilate (8CI)
  • Trancolon
  • Atenecolin-M
  • Eftoron
  • Mepenzolate Bromide (200 mg)
  • 3-(2-Hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-ium bromide
  • HCAR2,PUMA-G,inhibit,Muscarinic acetylcholine receptor,Inhibitor,hM3R,gastrointestinal,Chronic,HCA2,muscarinic,HM74A,mAChR,orally,pulmonary,COPD,Mepenzolate Bromide,obstructive,GPR109A,Mepenzolate,bronchodilatory,hypermotility,anti-inflammatory,hM2R
  • Piperidinium, 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-, bromide (1:1)
  • 76-90-4
  • C21H26BrNO3
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