3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
- Product Name
- 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
- CAS No.
- 67416-61-9
- Chemical Name
- 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
- Synonyms
- AKBA;Acetyl-11-keto-b-boswellic acid;Acetyl-11-keto-β-boswellic acid;3-acetyl-11-keto-β-Boswellic Acid;ACETYL-11-KETO-BETA-BOSWELLIC ACID;3-O-acetyl-11-keto-β-boswellic acid;3-O-Acetyl-11-keto-β-boswellic acid;AK-BETABA;AKBA, >98%;AKBA, 10 mM in DMSO
- CBNumber
- CB8309086
- Molecular Formula
- C32H48O5
- Formula Weight
- 512.73
- MOL File
- 67416-61-9.mol
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Property
- Melting point:
- 271℃
- Boiling point:
- 600.3±55.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 4.28±0.70(Predicted)
- color
- White to Off-White
- biological source
- Boswellia serrata
- LogP
- 7.418 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A9855
- Product name
- 3-Acetyl-11-keto-β-boswellic acid
- Packaging
- 5mg
- Price
- $417
- Updated
- 2024/03/01
- Product number
- 1076261
- Product name
- 3-Acetyl-11-keto-β-boswellic acid
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $741
- Updated
- 2024/03/01
- Product number
- 74607
- Product name
- 3-O-Acetyl-11-keto-β-boswellic acid
- Purity
- analytical standard
- Packaging
- 5MG
- Price
- $429
- Updated
- 2022/05/15
- Product number
- 11672
- Product name
- 3-acetyl-11-keto-β-Boswellic Acid
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 11672
- Product name
- 3-acetyl-11-keto-β-Boswellic Acid
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production
Description
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
Uses
3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent.
Definition
ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.
in vitro
akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1].
in vivo
pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1].
IC 50
1.5 μm
References
[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180.
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID manufacturers
- Product
- Acetyl-11-Keto-β -Boswellic Acid 67416-61-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-15
- Product
- Acetyl-11-keto-β-boswellic acid 67416-61-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-09-26
- Product
- Urs-12-en-23-oic acid,3-(acetyloxy)-11-oxo-, (3a,4b)- 67416-61-9
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09