Sacubitril Impurity 7

Product Name: Sacubitril Impurity 7
CAS No.: 149709-44-4
Chemical Name: Sacubitril Impurity 7
Synonyms: LBQ657;LCZ696-4;Sacubitrilat;Deethyl Sakuba;LCZ-696 Impurity 1;SACUBITRIL DI ACID;Diacid of Sacubitril;LCZ696 impurities124;LBQ-657(Sacubitrilat);Sacubitrilat (LBQ-657)
CBNumber: CB83133439
Molecular Formula: C22H25NO5
Formula Weight: 383.44
MOL File: 149709-44-4.mol

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Sacubitril Impurity 7 Property

Boiling point:: 705.4±60.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)
form: A crystalline solid
pka: 4.59±0.23(Predicted)
color: White to off-white
optical activity: [α]/D -35 to -27°, c =1 in methanol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19829
Product name: LBQ657
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 19829
Product name: LBQ657
Purity: ≥98%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 19829
Product name: LBQ657
Purity: ≥98%
Packaging: 10mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 19829
Product name: LBQ657
Purity: ≥98%
Packaging: 25mg
Price: $894
Updated: 2021/12/16

TRC

Product number: D288245
Product name: DesethylSacubitril
Packaging: 10mg
Price: $580
Updated: 2021/12/16

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Sacubitril Impurity 7 Chemical Properties,Usage,Production

Uses

Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biological Activity

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysinμs degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Sacubitril Impurity 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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Sacubitril Impurity 7 Suppliers

China 110 India 4 United States 10 Global 124

Adamas Reagent, Ltd.

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149709-44-4, Sacubitril Impurity 7Related Search:

(2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid

LCZ696-4

Diacid of Sacubitril

LBQ657

Sacubitrilat

LCZ-696 Impurity 1

Sacubitrilat (LBQ-657)

Sacubitril Desethyl Impurity

LCZ696 Impurity 900-04

Deethyl Sakuba

Sacubitril metabolite LBQ 657

[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, (αR,γS)-

4-[[(1S,3R)-1-[([1,1'-Biphenyl]-4-yl)methyl]-3-methyl-4-hydroxy-4-oxobutyl]amino]-4-oxobutanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)- 2-methylpentanoic aci

Diacid of Sacubitril/ Sacubitril Desethyl Impurity/ Sacubitrilat

LCZ696 impurities124

Sacubitril metabolite LBQ 657Q: What is Sacubitril metabolite LBQ 657 Q: What is the CAS Number of Sacubitril metabolite LBQ 657 Q: What is the storage condition of Sacubitril metabolite LBQ 657 Q: What are the applications of Sacubitril metabolite LBQ 657

quinoline,6-bromo-7-chloro-

SACUBITRIL DI ACID

Salcubatra calcium impurity J

LBQ-657(Sacubitrilat)

(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

Sacubitril metabolite LBQ 657-[d4]

Sacubitril Impurity 4 (LBQ-657) (desethyl) (Sacubitrilat)

Valsartan Impurity D-1

Sacubitril Diacid Impurity

LCZ696 impurity 900-04（LBQ657）

Sacubitrilat, 10 mM in DMSO

149709-44-4

14709-44-4