ChemicalBook > CAS DataBase List > Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-

Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-

Product Name: Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
CAS No.: 944561-46-0
Chemical Name: Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
Synonyms: CCCH2-PEG3-COOH;Alkyne-PEG2-CH2COOH;Propargyl-PEG2-CH2COOH;Propargyl-PEG3-CH2CO2H;2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetic acid;2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]acetic acid;2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)acetic acid;Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-;Propargyl-PEG2-CH2COOH/Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
CBNumber: CB83152069
Molecular Formula: C9H14O5
Formula Weight: 202.2
MOL File: 944561-46-0.mol

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Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Property

Boiling point:: 334.9±27.0 °C(Predicted)
Density: 1.158±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
form: Liquid
pka: 3.39±0.10(Predicted)
color: Colorless to light yellow

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS104181
Product name: Propargyl-PEG2-CH2COOH
Purity: 95+%
Packaging: 250mg
Price: $350
Updated: 2021/12/16

Activate Scientific

Product number: AS104181
Product name: Propargyl-PEG2-CH2COOH
Purity: 95+%
Packaging: 1g
Price: $655
Updated: 2021/12/16

AK Scientific

Product number: 9785DN
Product name: 2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)aceticacid
Packaging: 500mg
Price: $791
Updated: 2021/12/16

ChemScene

Product number: CS-M3521
Product name: Aceticacid,2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
Packaging: 1g
Price: $850
Updated: 2021/12/16

AK Scientific

Product number: 9785DN
Product name: 2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)aceticacid
Packaging: 1g
Price: $985
Updated: 2021/12/16

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Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Chemical Properties,Usage,Production

Description

Propargyl-PEG3-CH2CO2H is an PEG linker with an alkyne and carboxylic acid set of functional groups. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry to form stable triazole linkage. The carboxylic acid can react with primary amines to form stable amide bonds; activator (e.g. EDC, or HATU) is needed.

Uses

Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.

Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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944561-46-0, Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-Related Search:

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Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-

Propargyl-PEG2-CH2COOH

2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)acetic acid

2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]acetic acid

Propargyl-PEG2-CH2COOH/Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-

2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetic acid

CCCH2-PEG3-COOH

Alkyne-PEG2-CH2COOH

Propargyl-PEG3-CH2CO2H

944561-46-0