ChemicalBook > CAS DataBase List > Azido-PEG3-Maleimide

Azido-PEG3-Maleimide

Product Name
Azido-PEG3-Maleimide
CAS No.
1858264-36-4
Chemical Name
Azido-PEG3-Maleimide
Synonyms
N3-PEG3-Mal;Azido-PEG4-BMPA;Azide-PEG3-maleimide;Azido-PEG3-Maleimide;1H-Pyrrole-1-propanamide, N-[2-[2-[2-(2-azidoethoxy) ethoxy] ethoxy] ethyl]-2,5-dihydro-2,5-dioxo-
CBNumber
CB93162867
Molecular Formula
C15H23N5O6
Formula Weight
369.37302
MOL File
1858264-36-4.mol
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Chem-Impex
Product number
35111
Product name
Azido-PEG3-maleimide
Packaging
5MG
Price
$67.2
Updated
2021/12/16
BroadPharm
Product number
BP-22468
Product name
Azido-PEG3-Maleimide
Purity
95%
Packaging
25mg
Price
$95
Updated
2021/12/16
Chem-Impex
Product number
35111
Product name
Azido-PEG3-maleimide
Packaging
25MG
Price
$123.2
Updated
2021/12/16
ChemScene
Product number
CS-0114354
Product name
Azido-PEG3-maleimide
Packaging
25mg
Price
$165
Updated
2021/12/16
BroadPharm
Product number
BP-22468
Product name
Azido-PEG3-Maleimide
Purity
95%
Packaging
100mg
Price
$195
Updated
2021/12/16
More
Less

Azido-PEG3-Maleimide Chemical Properties,Usage,Production

Description

Azido-PEG3-Maleimide is provided as a kit of two vials. Azido-PEG3-Maleimide is not stable for storage; it needs to be made in situ by mixing Azido-PEG3-amine and Maleimide-NHS ester followed by shaking/ stirring for 30 minutes at room temperature. The maleimide group of the Azido-PEG3-Maleimide can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Azide group enables Click Chemsitry reactions.

Biological Activity

Azido-PEG3-maleimide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules. Azido-PEG3-maleimide is also a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Azido-PEG3-Maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Azido-PEG3-Maleimide Suppliers

Tel
19916721580
Fax
QQ:3154870176
Email
mafarm@126.com
Country
China
ProdList
4308
Advantage
58
Tel
0431-0431-80514535 19917294565
Email
et@chemextension.com
Country
China
ProdList
3987
Advantage
55
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10010
Advantage
58
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28812
Advantage
58
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Tel
571-86758373 +8613588754946
Fax
0086-571-81131109
Email
sales@huarongpharm.com
Country
CHINA
ProdList
3148
Advantage
58

1858264-36-4, Azido-PEG3-MaleimideRelated Search:


  • Azido-PEG3-Maleimide
  • N3-PEG3-Mal
  • Azide-PEG3-maleimide
  • Azido-PEG4-BMPA
  • 1H-Pyrrole-1-propanamide, N-[2-[2-[2-(2-azidoethoxy) ethoxy] ethoxy] ethyl]-2,5-dihydro-2,5-dioxo-
  • 1858264-36-4
  • peg
  • PEGs

    Cleavable