Bromo-PEG4-Azide
- Product Name
- Bromo-PEG4-Azide
- CAS No.
- 1951439-37-4
- Chemical Name
- Bromo-PEG4-Azide
- Synonyms
- N3-PEG4-Br;Bromo-PEG4-N3;Azido-PEG4-Br;N3-PEG4-CH2CH2Br;1-azido-14-bromo-3,6,9,12-tetraoxatetradecane;N3-PEG4-CH2CH2Br/3,6,9,12-Tetraoxatetradecane, 1-azido-14-bromo-;1-azido-2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethane - 95%
- CBNumber
- CB03162925
- Molecular Formula
- C10H21BrN3O4+
- Formula Weight
- 327.19544
- MOL File
- 1951439-37-4.mol
Bromo-PEG4-Azide Property
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Light yellow to yellow
Safety
- HS Code
- 2942000090
N-Bromosuccinimide Price
- Product number
- BP-22128
- Product name
- Bromo-PEG4-azide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- BP-22128
- Product name
- Bromo-PEG4-azide
- Purity
- 98%
- Packaging
- 500MG
- Price
- $650
- Updated
- 2021/12/16
- Product number
- AS107849
- Product name
- N3-PEG4-CH2CH2Br
- Purity
- 97%
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
- Product number
- BP-22128
- Product name
- Bromo-PEG4-azide
- Purity
- 98%
- Packaging
- 1g
- Price
- $980
- Updated
- 2021/12/16
- Product number
- B-1431
- Product name
- N3-PEG4-CH2CH2Br
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $247.5
- Updated
- 2021/12/16
Bromo-PEG4-Azide Chemical Properties,Usage,Production
Description
Bromo-PEG4-azide is a bifunctional crosslinker containing a bromide and a terminal azide. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a good leaving group for nucleophilic substitution. The azide(N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry.
Uses
Bromo-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Bromo-PEG4-Azide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bromo-PEG4-Azide manufacturers
- Product
- Azido-PEG4-Br 1951439-37-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23