1-isothiocyanato-PEG3-Azide
- Product Name
- 1-isothiocyanato-PEG3-Azide
- CAS No.
- 1310686-23-7
- Chemical Name
- 1-isothiocyanato-PEG3-Azide
- Synonyms
- NCS-peg3-azide;1-isothiocyanato-PEG3-Azide;1-Isothiocyanato PEG3-alcohol
- CBNumber
- CB63162806
- Molecular Formula
- C9H16N4O3S
- Formula Weight
- 260.31
- MOL File
- 1310686-23-7.mol
N-Bromosuccinimide Price
- Product number
- BP-22971
- Product name
- 1-isothiocyanato-PEG3-Azide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- BP-22971
- Product name
- 1-isothiocyanato-PEG3-Azide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- BP-22971
- Product name
- 1-isothiocyanato-PEG3-Azide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $690
- Updated
- 2021/12/16
- Product number
- BP-22971
- Product name
- 1-isothiocyanato-PEG3-Azide
- Purity
- 98%
- Packaging
- 1g
- Price
- $1150
- Updated
- 2021/12/16
1-isothiocyanato-PEG3-Azide Chemical Properties,Usage,Production
Uses
1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1-Isothiocyanato-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
1-isothiocyanato-PEG3-Azide Preparation Products And Raw materials
Raw materials
Preparation Products
1-isothiocyanato-PEG3-Azide Suppliers
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View Lastest Price from 1-isothiocyanato-PEG3-Azide manufacturers
- Product
- 1-Isothiocyanato-PEG3-azide 1310686-23-7
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-27