3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide
- Product Name
- 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide
- CAS No.
- 2170240-96-5
- Chemical Name
- 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide
- Synonyms
- INO-464;AZIDO-PEG4-HYDRAZIDE;Azido-PEG4-hydrazide HCI salt;Azido-PEG4-hydrazide HCl Salt;3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide
- CBNumber
- CB44809467
- Molecular Formula
- C11H23N5O5
- Formula Weight
- 305.33
- MOL File
- 2170240-96-5.mol
3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Property
- storage temp.
- -20°C, protect from light
- solubility
- DMSO : 100 mg/mL (327.51 mM)
- form
- Liquid
- color
- Colorless to light yellow
- Appearance
- white-yellow solid
N-Bromosuccinimide Price
- Product number
- BP-23874
- Product name
- Azido-PEG4-hydrazideHClSalt
- Purity
- 95%
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- BP-23874
- Product name
- Azido-PEG4-hydrazideHClSalt
- Purity
- 95%
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Chemical Properties,Usage,Production
Description
Azido-PEG4-hydrazide HCl salt is a PEG linker containing an azide group and a hydrazide group. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond.
Uses
Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid hydrazide manufacturers
- Product
- Azido-PEG4-hydrazide 2170240-96-5
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >98.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-23