Amfonelic acid

Product Name: Amfonelic acid
CAS No.: 15180-02-6
Chemical Name: Amfonelic acid
Synonyms: NCA;Amfonelic;WIN-25978;NSC-100638;Amphonic acid;AMFONELIC ACID;Diphenyl sulfide 139-66-2;AMFONELIC ACID INCREASES DOPAMINE RE;Amfonelic Acid/ CAS NO.15180-02-6/99%;7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci
CBNumber: CB8315692
Molecular Formula: C18H16N2O3
Formula Weight: 308.33
MOL File: 15180-02-6.mol

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Amfonelic acid Property

Melting point:: >1000 °C
Boiling point:: 499℃
Density: 1.297
Flash point:: 256℃
solubility: 0.1 M NaOH: soluble
form: powder
pka: 3.50±0.20(Predicted)
color: yellow
InChI: InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
InChIKey: WHHHJDGNBVQNAU-UHFFFAOYSA-N
SMILES: N1(CC)C2C(=CC=C(CC3=CC=CC=C3)N=2)C(=O)C(C(O)=O)=C1

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Safety

Hazard Codes: Xn
Risk Statements: 40-43
Safety Statements: 36/37
WGK Germany: 3
HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3356
Product name: Amfonelic Acid
Packaging: 10MG
Price: $475
Updated: 2024/03/01

Chem-Impex

Product number: 38450
Product name: Amfonelicacid,≥97%(HPLC)
Purity: ≥97%(HPLC)
Packaging: 10MG
Price: $546.29
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000377
Product name: AMFONELIC ACID
Purity: 95.00%
Packaging: 250MG
Price: $1067.22
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000377
Product name: AMFONELIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1428
Updated: 2021/12/16

AK Scientific

Product number: SYN5501
Product name: Amfonelic Acid
Packaging: 100mg
Price: $2268
Updated: 2021/12/16

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Amfonelic acid Chemical Properties,Usage,Production

Description

Amfonelic acid, a derivative of nalidixic acid, was originally developed as a central nervous system stimulant. It is a highly potent nonamphetamine stimulant whose actions are inhibited by reserpine but not by the tyrosine hydroxylase inhibitor, a-methyltyrosine. Additionally, it enhances the impacts of antipsychotic medicines such as haloperidol, trifluoperazine, and spiperone.

Uses

Amfonelic acid (AFA) is a dopamine reuptake inhibitor, that has marked effects on brain dopamine metabolism but not noradrenaline metabolism. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. Rats are shown to self-administer amfonelic acid in a dose-dependent manner.

Biological Activity

Amfonelic acid (AFA), an inhibitor of dopamine (DA) uptake, has been found to increase the levels of tryptophan (TRYP) and 5-hydroxyindoleacetic acid (5-HIAA) in the rat c. striatum, cerebral cortex, and brain stem. The duration of action of the effect of AFA on TRYP and 5-HIAA appeared to be longer than that of the increase of the striatal DA metabolites homovanillic acid and 3,4-dihydroxyphenylacetic acid[1].

References

The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward DOI: 10.1016/0091-3057(89)90069-5
Pharmacologic properties and mechanism of action of amfonelic acid DOI: 10.1016/0014-2999(70)90206-2

References

[1] P C Waldmeier. “The effects of amfonelic acid on 5-HT metabolism in rat brain.” Journal of Neural Transmission 57 3 (1983): 149–65.

Amfonelic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Amfonelic acid Suppliers

Americas 1 China 81 Europe 1 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 4 United States 10 Global 101

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Shanghai Chainpharm Bio-medical Technology Co., Ltd.

Tel: 021-61727342 13611721451
Fax: 021-61294107
Email: sales@chainpharm.com
Country: China
ProdList: 958
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

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Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6463
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

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View Lastest Price from Amfonelic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Amfonelic acid 15180-02-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid 15180-02-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 50kg
Release date: 2023-10-08

Henan Fengda Chemical Co., Ltd

Product: Amfonelic acid 15180-02-6
Price: US $33.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-25

15180-02-6, Amfonelic acidRelated Search:

Amfonelic acid 2-Amino-6-methylpyridine 2-Amino-4-methylpyrimidine 2-Amino-3-acetylpyridine ISOAMYLAMINE 3-PROPIONYLPYRIDINE 5-Ethyl-2-methylpyridine 2-AMINO-3-ETHYL-6-METHYLPYRIDINE 2-Dimethylaminopyridine 2-Methylaminopyridine-3-carbaldehyde 2-AMINO-6-ETHYLPYRIDINE 2-Amino-3-pyridinecarboxaldehyde Nalidixic acid 5-ACETYL-2-METHYLPYRIDINE 3-Pyridinepropanol 3-FORMYL-6-METHYL-PYRIDINE 3-Pyridinepropionic acid 3,6-DIMETHYL-2-PYRIDINAMINE

AMFONELIC ACID

1,8-Naphthyridine-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-7-(phenylMethyl)-

7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic acid

AMFONELIC ACID INCREASES DOPAMINE RE

amfonelic acid (7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid)

Amfonelic

7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

NCA

NSC-100638

WIN-25978

7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

Hot Selling Amfonelic Acid Powder?15180-02-6?with Best Price From Wujiaren Lab

7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci

Amfonelic Acid/ CAS NO.15180-02-6/99%

Diphenyl sulfide 139-66-2

Amphonic acid

15180-02-6