Amfonelic acid

ChemicalBook > CAS DataBase List > Amfonelic acid

Product Name: Amfonelic acid
CAS No.: 15180-02-6
Chemical Name: Amfonelic acid
Synonyms: NCA;Amfonelic;WIN-25978;NSC-100638;Amphonic acid;AMFONELIC ACID;Diphenyl sulfide 139-66-2;AMFONELIC ACID INCREASES DOPAMINE RE;Amfonelic Acid/ CAS NO.15180-02-6/99%;7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci
CBNumber: CB8315692
Molecular Formula: C18H16N2O3
Formula Weight: 308.33
MOL File: 15180-02-6.mol

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Amfonelic acid Property

Melting point:: >1000 °C
Boiling point:: 499℃
Density: 1.297
Flash point:: 256℃
solubility: 0.1 M NaOH: soluble
form: powder
pka: 3.50±0.20(Predicted)
color: yellow
InChI: InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
InChIKey: WHHHJDGNBVQNAU-UHFFFAOYSA-N
SMILES: N1(CC)C2C(=CC=C(CC3=CC=CC=C3)N=2)C(=O)C(C(O)=O)=C1

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Safety

Hazard Codes: Xn
Risk Statements: 40-43
Safety Statements: 36/37
WGK Germany: 3
HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3356
Product name: Amfonelic Acid
Packaging: 10MG
Price: $475
Updated: 2024/03/01

Chem-Impex

Product number: 38450
Product name: Amfonelicacid,≥97%(HPLC)
Purity: ≥97%(HPLC)
Packaging: 10MG
Price: $546.29
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000377
Product name: AMFONELIC ACID
Purity: 95.00%
Packaging: 250MG
Price: $1067.22
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000377
Product name: AMFONELIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1428
Updated: 2021/12/16

AK Scientific

Product number: SYN5501
Product name: Amfonelic Acid
Packaging: 100mg
Price: $2268
Updated: 2021/12/16

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Amfonelic acid Chemical Properties,Usage,Production

Description

Amfonelic acid, a derivative of nalidixic acid, was originally developed as a central nervous system stimulant. It is a highly potent nonamphetamine stimulant whose actions are inhibited by reserpine but not by the tyrosine hydroxylase inhibitor, a-methyltyrosine. Additionally, it enhances the impacts of antipsychotic medicines such as haloperidol, trifluoperazine, and spiperone.

Uses

Amfonelic acid (AFA) is a dopamine reuptake inhibitor, that has marked effects on brain dopamine metabolism but not noradrenaline metabolism. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. Rats are shown to self-administer amfonelic acid in a dose-dependent manner.

Biological Activity

Amfonelic acid (AFA), an inhibitor of dopamine (DA) uptake, has been found to increase the levels of tryptophan (TRYP) and 5-hydroxyindoleacetic acid (5-HIAA) in the rat c. striatum, cerebral cortex, and brain stem. The duration of action of the effect of AFA on TRYP and 5-HIAA appeared to be longer than that of the increase of the striatal DA metabolites homovanillic acid and 3,4-dihydroxyphenylacetic acid[1].

References

The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward DOI: 10.1016/0091-3057(89)90069-5
Pharmacologic properties and mechanism of action of amfonelic acid DOI: 10.1016/0014-2999(70)90206-2

References

[1] P C Waldmeier. “The effects of amfonelic acid on 5-HT metabolism in rat brain.” Journal of Neural Transmission 57 3 (1983): 149–65.

Amfonelic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amfonelic acid manufacturers

Henan Fengda Chemical Co., Ltd

Product: Amfonelic acid 15180-02-6
Price: US $33.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-25

Hebei Yanxi Chemical Co., Ltd.

Product: 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid 15180-02-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 50kg
Release date: 2023-10-08

LY Global chemicals co.,ltd .

Product: Amfonelic acid 15180-02-6
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 97% HPLC
Supply Ability: 100 KG
Release date: 2023-12-04

15180-02-6, Amfonelic acidRelated Search:

Amfonelic acid 2-Amino-6-methylpyridine 2-Amino-4-methylpyrimidine 2-Amino-3-acetylpyridine ISOAMYLAMINE 3-PROPIONYLPYRIDINE 5-Ethyl-2-methylpyridine 2-AMINO-3-ETHYL-6-METHYLPYRIDINE 2-Dimethylaminopyridine 2-Methylaminopyridine-3-carbaldehyde 2-AMINO-6-ETHYLPYRIDINE 2-Amino-3-pyridinecarboxaldehyde Nalidixic acid 5-ACETYL-2-METHYLPYRIDINE 3-Pyridinepropanol 3-FORMYL-6-METHYL-PYRIDINE 3-Pyridinepropionic acid 3,6-DIMETHYL-2-PYRIDINAMINE

AMFONELIC ACID

1,8-Naphthyridine-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-7-(phenylMethyl)-

7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic acid

AMFONELIC ACID INCREASES DOPAMINE RE

amfonelic acid (7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid)

Amfonelic

7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

NCA

NSC-100638

WIN-25978

7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

Hot Selling Amfonelic Acid Powder?15180-02-6?with Best Price From Wujiaren Lab

7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci

Amfonelic Acid/ CAS NO.15180-02-6/99%

Diphenyl sulfide 139-66-2

Amphonic acid

15180-02-6