Amfonelic acid
- Product Name
- Amfonelic acid
- CAS No.
- 15180-02-6
- Chemical Name
- Amfonelic acid
- Synonyms
- NCA;Amfonelic;WIN-25978;NSC-100638;Amphonic acid;AMFONELIC ACID;Diphenyl sulfide 139-66-2;AMFONELIC ACID INCREASES DOPAMINE RE;Amfonelic Acid/ CAS NO.15180-02-6/99%;7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci
- CBNumber
- CB8315692
- Molecular Formula
- C18H16N2O3
- Formula Weight
- 308.33
- MOL File
- 15180-02-6.mol
Amfonelic acid Property
- Melting point:
- >1000 °C
- Boiling point:
- 499℃
- Density
- 1.297
- Flash point:
- 256℃
- solubility
- 0.1 M NaOH: soluble
- form
- powder
- pka
- 3.50±0.20(Predicted)
- color
- yellow
- InChI
- InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
- InChIKey
- WHHHJDGNBVQNAU-UHFFFAOYSA-N
- SMILES
- N1(CC)C2C(=CC=C(CC3=CC=CC=C3)N=2)C(=O)C(C(O)=O)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3356
- Product name
- Amfonelic Acid
- Packaging
- 10MG
- Price
- $475
- Updated
- 2024/03/01
- Product number
- 38450
- Product name
- Amfonelicacid,≥97%(HPLC)
- Purity
- ≥97%(HPLC)
- Packaging
- 10MG
- Price
- $546.29
- Updated
- 2021/12/16
- Product number
- API0000377
- Product name
- AMFONELIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1067.22
- Updated
- 2021/12/16
- Product number
- API0000377
- Product name
- AMFONELIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1428
- Updated
- 2021/12/16
- Product number
- SYN5501
- Product name
- Amfonelic Acid
- Packaging
- 100mg
- Price
- $2268
- Updated
- 2021/12/16
Amfonelic acid Chemical Properties,Usage,Production
Description
Amfonelic acid, a derivative of nalidixic acid, was originally developed as a central nervous system stimulant. It is a highly potent nonamphetamine stimulant whose actions are inhibited by reserpine but not by the tyrosine hydroxylase inhibitor, a-methyltyrosine. Additionally, it enhances the impacts of antipsychotic medicines such as haloperidol, trifluoperazine, and spiperone.
Uses
Amfonelic acid (AFA) is a dopamine reuptake inhibitor, that has marked effects on brain dopamine metabolism but not noradrenaline metabolism. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. Rats are shown to self-administer amfonelic acid in a dose-dependent manner.
Biological Activity
Amfonelic acid (AFA), an inhibitor of dopamine (DA) uptake, has been found to increase the levels of tryptophan (TRYP) and 5-hydroxyindoleacetic acid (5-HIAA) in the rat c. striatum, cerebral cortex, and brain stem. The duration of action of the effect of AFA on TRYP and 5-HIAA appeared to be longer than that of the increase of the striatal DA metabolites homovanillic acid and 3,4-dihydroxyphenylacetic acid[1].
References
The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward DOI: 10.1016/0091-3057(89)90069-5
Pharmacologic properties and mechanism of action of amfonelic acid DOI: 10.1016/0014-2999(70)90206-2
References
[1] P C Waldmeier. “The effects of amfonelic acid on 5-HT metabolism in rat brain.” Journal of Neural Transmission 57 3 (1983): 149–65.
Amfonelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Amfonelic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from Amfonelic acid manufacturers
- Product
- Amfonelic acid 15180-02-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid 15180-02-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 50kg
- Release date
- 2023-10-08
- Product
- Amfonelic acid 15180-02-6
- Price
- US $33.00-1.40/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-25