ChemicalBook > CAS DataBase List > BOC-L-NORLEUCINE

BOC-L-NORLEUCINE

Product Name
BOC-L-NORLEUCINE
CAS No.
6404-28-0
Chemical Name
BOC-L-NORLEUCINE
Synonyms
BOC-NLE-OH;BOC-L-NLE-OH;BOC-AHX(2)-OH;BOC-NORLEUCINE;BOC-ACPO(2)-OH;BOC-L-NORLEUCINE;N-BOC-L-NORLEUCINE;Boc-Nle-OH (syrup);Boc-L-norleucine99%;RARECHEM EM WB 0164
CBNumber
CB8319221
Molecular Formula
C11H21NO4
Formula Weight
231.29
MOL File
6404-28-0.mol
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BOC-L-NORLEUCINE Property

Boiling point:
373.37°C (rough estimate)
Density 
1.1202 (rough estimate)
refractive index 
1.4425
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
4.02±0.21(Predicted)
color 
Colorless to light yellow
optical activity
[α]20/D 8±1°, c = 1% in methanol
BRN 
3608376
CAS DataBase Reference
6404-28-0(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29224985
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15555
Product name
Boc-Nle-OH
Purity
≥99.0% (TLC)
Packaging
5g
Price
$342
Updated
2025/07/31
Usbiological
Product number
236445
Product name
Boc-L-norleucine 99+%
Packaging
1g
Price
$163
Updated
2021/12/16
Usbiological
Product number
264631
Product name
Boc-L-norleucine
Packaging
2g
Price
$333
Updated
2021/12/16
ChemScene
Product number
CS-0019199
Product name
Norleucine,N-carboxy-,N-tert-butylester
Packaging
25g
Price
$138
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB47085
Product name
Boc-L-norleucine
Packaging
10g
Price
$163.9
Updated
2021/12/16
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BOC-L-NORLEUCINE Chemical Properties,Usage,Production

Uses

A boc protected amino acid derivative

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

327-57-1

24424-99-5

6404-28-0

The general procedure for the synthesis of N-BOC-L-norleucine from L-norleucine and di-tert-butyl dicarbonate was as follows: free L-norleucine (400 mg, 3.05 mmol) was dissolved in a solvent mixture of water and THF (8.8 mL:8.8 mL), NaHCO3 (768 mg, 9.15 mmol) was added and di-tert-butyl dicarbonate ( 800 mg, 3.66 mmol). The reaction mixture was stirred at 0 °C for 30 min, then gradually warmed to room temperature and continued to stir overnight. Upon completion of the reaction, water (10 mL) was added to dissolve any precipitate that may have formed. Unreacted di-tert-butyl dicarbonate was removed by three extractions with petroleum ether. N-BOC-L-norleucine in the aqueous phase was acidified to pH ≈ 3 with 1 M NaHSO4 solution and subsequently extracted three times with EtOAc. The organic layers were combined and dried with Na2SO4. The solvent was removed by concentration under reduced pressure to give the clear oily product N-BOC-L-norleucine (573 mg, 81% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 12.38 (bs, 1H, COOH), 7.02 (d, J=8.2 Hz, 1H, NH), 3.87-3.78 (m, 1H, CH), 1.69-1.47 (m, 2H, CH2), 1.37 (s, 9H, t-Bu), 1.32- 1.20 (m, 4H, CH2), 0.85 (t, J=7.0Hz, 3H, CH3).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6891 - 6899
[2] Bioorganic and medicinal chemistry letters, 2004, vol. 14, # 1, p. 275 - 278

BOC-L-NORLEUCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-NORLEUCINE Suppliers

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View Lastest Price from BOC-L-NORLEUCINE manufacturers

Career Henan Chemical Co
Product
BOC-L-NORLEUCINE 6404-28-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

6404-28-0, BOC-L-NORLEUCINERelated Search:

N-BOC-L-Prolinal BOC-ARG-OH N-Boc-L-phenylalaninal (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL BOC-D-ABU-OH N-Boc-L-Phenylalaninol N-Boc-L-tert-Leucine BOC-L-Prolinol N-Boc-L-alaninol Boc-Lys(Boc)-OH BOC-LYS(AC)-OH BOC-LYS(TFA)-OH N-Boc-N'-Cbz-L-lysine BOC-LYS(Z)-OH DCHA Boc-Lys-OH BOC-L-2-AMINOADIPIC ACID N-Boc-N'-Fmoc-L-Lysine BOC-D-NORLEUCINE LIQUID,N-T-BOC-D-NORLEUCINE,BOC-D-NORLEUCINE

  • (S)-2-((tert-Butoxycarbonyl)aMino)hexanoic acid
  • N-[(1,1-Dimethylethoxy)carbonyl]-L-norleucine
  • BOC-L-Norleucine,98%
  • N-Boc-L-Norleucine (Dry wt.), May Cont. up to ca 10% Solvent
  • Norleucine, N-carboxy-, N-tert-butyl ester
  • (Tert-Butoxy)Carbonyl Nle-OH (Syrup)
  • Boc-(S)-2-aminohexanoicacid
  • BOC-L-NORLEUCINE
  • BOC-L-NLE-OH
  • BOC-L-NHCH[CH3(CH2)3]-COOH
  • BOC-NLE-OH
  • BOC-NORLEUCINE
  • BOC-AHX(2)-OH
  • BOC-ACPO(2)-OH
  • BOC-L-2-AMINOCAPROIC ACID
  • BOC-L-2-AMINOHEXANOIC ACID
  • (S)-2-(Boc-amino)hexanoic acid
  • Boc-L-norleucine99%
  • (S)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID
  • RARECHEM EM WB 0164
  • N-(TERT-BUTOXYCARBONYL)-L-NORLEUCIN
  • N-BOC-L-NORLEUCINE
  • N-ALPHA-T-BOC-L-NORLEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-2-AMINO-CAPROIC ACID
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-NORLEUCINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-NORLEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-NORLEUCINE
  • (s)-2-(boc-amino)caproic acid
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-NORLEUCINE, (S)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID
  • BOC-L-NORLEUCINE LIQUID
  • Boc-L-2-aminohexanoic acid (syrup)
  • Boc-Nle-OH (syrup)
  • N-Boc-L-norleucine, 98%(dry wt.), may cont. up to ca 10% solvent
  • N-(tert-Butoxycarbonyl)norleucine
  • N-(tert-Butyloxycarbonyl)-L-norleucine
  • Boc-Nle-OH Boc-Norleucine
  • L-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-
  • BOC-L-NORLEUCINE USP/EP/BP
  • (S)-2-((tertbutyloxyoxo)amino)hexanoic acid
  • Boc-Nle-OH/99%/6404-28-0
  • 6404-28-0
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Norleucine
  • Specialty Synthesis
  • Amino Acids