Nifekalant hydrochloride
- Product Name
- Nifekalant hydrochloride
- CAS No.
- 130656-51-8
- Chemical Name
- Nifekalant hydrochloride
- Synonyms
- ms551;Shinbit;NIFEKALANT HCL;NIFEKALANT HYDROCHLORIDE;Nifekalant 130636-43-0 /;Nifekalant hydrochloride (MS-551);Nifekalant hydrochloride USP/EP/BP;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride;1,3-Dimethyl-6-((2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino)-2,4(1H),3H)-pyrimidinedione HCl;1,3-Dimethyl-6-[2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino]-2,4(1H,3H)-pyrimidinedione hydrochloride
- CBNumber
- CB8325413
- Molecular Formula
- C19H28ClN5O5
- Formula Weight
- 441.91
- MOL File
- 130656-51-8.mol
Nifekalant hydrochloride Property
- Melting point:
- 172-174°
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
- form
- Solid
- pka
- 7.05(at 25℃)
- color
- Light Yellow to Yellow
- CAS DataBase Reference
- 130656-51-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20997
- Product name
- Nifekalant (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20997
- Product name
- Nifekalant (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 20997
- Product name
- Nifekalant (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 20997
- Product name
- Nifekalant (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- N457100
- Product name
- NifekalantHydrochloride
- Packaging
- 1g
- Price
- $1165
- Updated
- 2021/12/16
Nifekalant hydrochloride Chemical Properties,Usage,Production
Description
Nifekalant is a novel and pure class III anti-arrhythmic agent introduced in Japan as Shinbit injection for the treatment of serious ventricular arrhythmias. It can be synthesized in 3 steps with a final assembly of two ethanolamine blocks. Nifekalant is a non-selective blocker of myocardial repolarizing potassium currents and is completely devoid of any β-adrenergic blocking effect . In hearts from different species, Nifekalant significantly prolonged action potential duration, atrial and ventricular refractory periods in in situ and in isolation studies. In intact animals, hemodynamic parameters were not affected by doses up to 1 mg/kg. The specific characteristics of its voltage- and timedependent K+ current blockade might differentiate Nifekalant from other class III agents currently in use.
Description
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 μM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 μM).
Chemical Properties
Yellow Solid
Originator
Mitsui (Japan)
Uses
Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.
Definition
ChEBI: Nifekalant hydrochloride is an amine. It contains a Nifekalant.
brand name
Shinbit
Nifekalant hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Nifekalant hydrochloride Suppliers
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View Lastest Price from Nifekalant hydrochloride manufacturers
- Product
- Nifekalant hydrochloride 130656-51-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Nifekalant hydrochloride 130656-51-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-11
- Product
- Nifekalant hydrochloride 130656-51-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-11