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Labetalol hydrochloride

Product Name
Labetalol hydrochloride
CAS No.
32780-64-6
Chemical Name
Labetalol hydrochloride
Synonyms
LABETALOL HCL;normodyne;5-[1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYL)-AMINO]ETHYL]SALICYLAMIDE HYDROCHLORIDE;ipolab;labelol;ah5158a;amipress;Trandate;labrocol;presdate
CBNumber
CB8334888
Molecular Formula
C19H25ClN2O3
Formula Weight
364.87
MOL File
32780-64-6.mol
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Labetalol hydrochloride Property

Melting point:
187-189°
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
powder
color 
white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
CV5376000
HS Code 
2924296000
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 114, 120, 113, 107 i.p.; 47, 54, 60, 53 i.v.; 1450, 1800, 4550, 4000 orally (Shimpo)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L1011
Product name
Labetalol hydrochloride
Purity
>98% (TLC), powder
Packaging
5g
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
1356654
Product name
Labetalol hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
20249
Product name
Labetalol (hydrochloride)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20249
Product name
Labetalol (hydrochloride)
Purity
≥98%
Packaging
5g
Price
$93
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1335
Product name
Labetalol Hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$97.5
Updated
2024/03/01
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Labetalol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White or almost white powder.

Chemical Properties

Labetalol HCl is a white or off-white crystalline powder, soluble in water. Labetalol hydrochloride injection is a clear, colorless to light yellow, aqueous, sterile, isotonic solution for intravenous (IV) injection. It has a pH range of 3.0 to 4.5. Each mL contains 5 mg labetalol hydrochloride USP, 45 mg anhydrous dextrose, 0.10 mg edetate disodium; 0.80 mg of methylparaben and 0.10 mg of propylparaben as preservatives; and citric acid monohydrate and sodium hydroxide, as necessary, to bring the solution into the pH range[1].

Originator

Trandate,Allen and Hanburys,UK,1977

Uses

tropane alkaloid, anticholinergic drug

Uses

vasoconstrictor

Definition

ChEBI: Labetalol hydrochloride is a member of salicylamides.

Indications

Labetalol hydrochloride is indicated for the control of blood pressure in patients with severe hypertension. Labetalol hydrochloride is also used to treat severe or mild pregnancy hypertension (PIH).

Manufacturing Process

(a) 5-Bromoacetylsalicylamide (2.6 g), N-benzyl-N-(1-methyl-3-phenylpropyl) amine (4.8 g) and methyl ethyl ketone (50 ml) were heated at reflux for 40 minutes. The solvent was removed and the residue was treated with benzene. The secondary amine hydrobromide was filtered off and discarded, and the filtrate was evaporated to dryness. The residue was treated with an excess of ethanolic hydrogen chloride when 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)- glycyl]-salicylamide hydrochloride (1.15 g) crystallized out, MP 139°C to 141°C.
(b) 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)glycyl]-salicylamide hydrochloride (0.75 g), 10% mixture of PdO and PtO on carbon catalyst (0.1 g) and ethanol (20 ml) were shaken at room temperature and pressure with hydrogen until uptake ceased. The catalyst was filtered off and the filtrate evaporated to dryness. The residue was crystallized from ethanol to give 5-[1- hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl]salicylamide hydrochloride as a white solid (0.40 g), MP 188°C.

brand name

Normodyne (Schering); Trandate (Promethus).

Therapeutic Function

Alpha-adrenergic blocker, Beta-adrenergic blocker

Biological Activity

labetalol hcl is a selective antagonist for the α1-adrenergic receptor and a non-selective antagonist for the β-adrenergic receptor. labetalol hcl has been used for the treatment of high blood pressure. labetalol hcl competitively targets the α1-adrenergic receptors expressed in vascular smooth muscle, thus inhibiting adrenergic stimulation on endothelial cells and vasoconstriction in peripheral blood vessels. labetalol hcl also blocks the β-adrenergic receptors in bronchial and vascular smooth muscle to counteract adrenergic stimulation. ultimately, labetalol hcl causes decreases in resting and exercise heart rates, cardiac output, as well as in both systolic and diastolic blood pressure, exherting vasodilation, as well as negative chronotropic and inotropic cardiac effects.1. national center for biotechnology information (2021). pubchem compound summary for cid 3869, labetalol. retrieved august 21, 2021.2. dage rc, hsieh cp. direct vasodilatation by labetalol in anaesthetized dogs. british journal of pharmacology, 1980, 70(2): 287-293.

References

[1] Labetalol Hydrochloride[J]. Definitions, 2020. DOI:10.1002/9780470909799.ch11.

Labetalol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Labetalol hydrochloride Suppliers

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View Lastest Price from Labetalol hydrochloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Labetalol hydrochloride 32780-64-6
Price
US $1000.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Labetalol hydrochloride 32780-64-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101.0%
Supply Ability
500kgs
Release date
2021-08-10
Apeloa production Co.,Limited
Product
Labetalol HCl 32780-64-6
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000
Release date
2024-05-22

32780-64-6, Labetalol hydrochlorideRelated Search:

5-acetyl-2-(phenylmethoxy)benzamide Labetalol IMpurity A Labetalol EP impurity D 5-formyl-2-hydroxybenzamide 5-(N,N-Dibenzylglycyl)salicylamide MDAT Labetalone hydrochloride DILEVALOL HYDROCHLORIDE Labetalol IMpurity B 5-(bromoacetyl)-2-(phenylmethoxy)benzamide (R)-N-benzyl-4-phenylbutan-2-amine Labetalol EP impurity C 5-(2-Bromo-1-hydroxyethyl)-2-hydroxy-benzoic Acid Methyl Ester Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride） rac 4-(3-Aminobutyl)phenol Salicylamide DILEVALOL SYNEPHRINE

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  • 2-hydroxy-5-(1-hydroxy-2-((R)-4-phenylbutan-2-ylamino)ethyl)benzamide hydrochloride
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  • C19H24N2O3HCl
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  • C19H24N2O3HClC19H25ClN2
  • WYAMINE