Urelumab

Product Name: Urelumab
CAS No.: 934823-49-1
Chemical Name: Urelumab
Synonyms: Urelumab;BMS-663513;anti-4-1BB antibody;BMS-663513|||BMS-66513;Research Grade Urelumab;Urelumab (anti-TNFRSF9);Research Grade Urelumab(DHG11002)
CBNumber: CB83363719
Formula Weight: 0
MOL File: Mol file

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Urelumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Urelumab Chemical Properties,Usage,Production

Uses

Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL)[1].

Biological Activity

Urelumab has been used in trials studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and Cancer - Solid Tumors and B-Cell Non-Hodgkin's Lymphoma. Urelumab is a fully human antibody that targets CD137. The antibody product was developed using Medarex's UltiMAb(R) technology and was the first UltiMAb- derived antibody in clinical development by Bristol-Myers Squibb under the December 2003 agreement with Medarex.

in vivo

Urelumab (0.3-1 mg/kg, i.p., once every 3 days, 6 times) reduces the tumor volume and tumor weight in humanized 4-1BB mice^[2].
Urelumab (3-30 mg/kg, i.p., once every 3 days, 6 times) exhibits high safety in humanized 4-1BB mice^[2].

target

4-1BB

References

[1] John Timmerman, et al. Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma. Am J Hematol. 2020 May;95(5):510-520. DOI:10.1002/ajh.25757
[2] Cheng LS, et al. A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity. J Transl Med. 2022 Sep 8;20(1):415. DOI:10.1186/s12967-022-03619-w

Urelumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Urelumab Suppliers

China 22 United States 3 Global 25

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934823-49-1, UrelumabRelated Search:

varlilumab Eptinezumab Atezolizumab Obinutuzumab Sutimlimab Utomilumab Glofitamab Nesvacumab Odronextamab Rituximab

Urelumab

Research Grade Urelumab(DHG11002)

BMS-663513

Urelumab (anti-TNFRSF9)

BMS-663513|||BMS-66513

anti-4-1BB antibody

Research Grade Urelumab

934823-49-1