AX-024 hydrochloride
- Product Name
- AX-024 hydrochloride
- CAS No.
- 1704801-24-0
- Chemical Name
- AX-024 hydrochloride
- Synonyms
- AX-024;AX-024;AX024;AX 024;AX-024 hydrochloride;AX-024 hydrochloride, 10 mM in DMSO;1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride;AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
- CBNumber
- CB83364105
- Molecular Formula
- C21H23ClFNO2
- Formula Weight
- 375.87
- MOL File
- 1704801-24-0.mol
AX-024 hydrochloride Property
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 27333
- Product name
- AX-024 (hydrochloride)
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 27333
- Product name
- AX-024 (hydrochloride)
- Packaging
- 25mg
- Price
- $680
- Updated
- 2024/03/01
- Product number
- 27333
- Product name
- AX-024 (hydrochloride)
- Packaging
- 5mg
- Price
- $167
- Updated
- 2024/03/01
- Product number
- 27333
- Product name
- AX-024 (hydrochloride)
- Packaging
- 10mg
- Price
- $312
- Updated
- 2024/03/01
- Product number
- CS-8002
- Product name
- AX-024hydrochloride
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
AX-024 hydrochloride Chemical Properties,Usage,Production
Description
AX-024 is an inhibitor of the CD3ε-Nck interaction. It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox).
Uses
AX-024 is a T cell receptor inhibitor for the treatment of autoimmune diseases.
in vivo
The AX-024 hydrochloride-treated group presents less scales and reduces skin thickening compare to the vehicle group. AX-024 hydrochloride significantly reduces thickening of both skin layers, but more effectively of the dermis, which rather resembles that of mice treated with a control cream lacking imiquimod (IMQ). AX-024 hydrochloride significantly diminishes the number of airway inflammatory cells in both assays. Mice receiving AX-024 hydrochloride rapidly recovers from neurological impairment and weight loss, becoming symptom-free by day 30, unlike mice that receives the vehicle, in which ataxia and loss of the righting reflex persist[1].
IC 50
IL-6; IL-10; IL-17A
References
[1] ALDO BORROTO. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases[J]. Science Translational Medicine, 2016, 8 370. DOI:10.1126/scitranslmed.aaf2140
AX-024 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
AX-024 hydrochloride Suppliers
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