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ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate

Product Name
ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate
CAS No.
118988-04-8
Chemical Name
ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate
Synonyms
HO-PEG3-CH2COOEt;Hydroxy-PEG3-ethyl acetate;ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate;Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, ethyl ester;HO-PEG3-CH2COOEt/Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, ethyl ester
CBNumber
CB83367469
Molecular Formula
C10H20O6
Formula Weight
236.26
MOL File
118988-04-8.mol
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ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Property

Boiling point:
332.3±27.0 °C(Predicted)
Density 
1.105±0.06 g/cm3(Predicted)
pka
14.36±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Acrotein
Product number
B-1228
Product name
HO-PEG3-CH2COOEt
Purity
97%
Packaging
1g
Price
$412.5
Updated
2021/12/16
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ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Chemical Properties,Usage,Production

Biological Activity

Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate Suppliers

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