ChemicalBook > CAS DataBase List > 4-Amino-4'-chlorodiphenyl ether

4-Amino-4'-chlorodiphenyl ether

Product Name
4-Amino-4'-chlorodiphenyl ether
CAS No.
101-79-1
Chemical Name
4-Amino-4'-chlorodiphenyl ether
Synonyms
SALOR-INT L300845-1EA;Amoxapine Impurity 21;4-Chlorophenoxyaniline;p-(p-chlorophenoxy)-anilin;P-(P-CHLOROPHENOXY)ANILINE;4-(4-CHLOROPHENOXY)ANILINE;4-(p-Chlorophenoxy)aniline;4-(4'-CHLOROPHENOXY)ANILINE;4-(4-Chlorophenoxy)benzamide;4-(4-CHLOROPHENOXY)BENZENAMINE
CBNumber
CB8341082
Molecular Formula
C12H10ClNO
Formula Weight
219.67
MOL File
101-79-1.mol
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4-Amino-4'-chlorodiphenyl ether Property

Melting point:
99-103 °C
Boiling point:
205 °C / 12mmHg
Density 
1.1764 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
4.60±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
Water Solubility 
Insoluble in water.
CAS DataBase Reference
101-79-1(CAS DataBase Reference)
EPA Substance Registry System
Benzenamine, 4-(4-chlorophenoxy)- (101-79-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-40-43-41-37/38-22
Safety Statements 
26-36/37/39-36/37
WGK Germany 
3
RTECS 
BX1770000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29222990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
695386
Product name
4-(4-Chlorophenoxy)aniline
Purity
97%
Packaging
5g
Price
$88.7
Updated
2023/06/20
Sigma-Aldrich
Product number
695386
Product name
4-(4-Chlorophenoxy)aniline
Purity
97%
Packaging
25g
Price
$215
Updated
2023/01/07
TCI Chemical
Product number
C1069
Product name
4-Amino-4'-chlorodiphenyl Ether
Purity
min. 98.0 %
Packaging
5G
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
C1069
Product name
4-Amino-4'-chlorodiphenyl Ether
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$150
Updated
2025/07/31
Apolloscientific
Product number
OR29829
Product name
4-(4-Chlorophenoxy)aniline
Packaging
10g
Price
$21
Updated
2021/12/16
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4-Amino-4'-chlorodiphenyl ether Chemical Properties,Usage,Production

Chemical Properties

Dark powder

Uses

It is used as an active pharmaceutical intermediate.

Synthesis

1836-74-4

101-79-1

General procedure for the synthesis of 4'-chloro-4-amino-diphenyl ether from 4'-chloro-4-nitro-diphenyl ether: general method: 1-substituted-4-nitrobenzene (9.3 mmol) and hydrazine hydrate (27.9 mmol) were dissolved in 20 mL of ethanol, and stirred for 10 min at 28-30°C. The reaction was carried out in aqueous suspension of Raney-Ni (0.02 g). An aqueous suspension of Raney-Ni (0.02 g, 4.41 mL) was added in three 10-min intervals. after 30 min, the reaction was allowed to plateau, and the temperature was raised to 50-60 °C to continue stirring for 6 h. The catalyst was removed by filtration. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by evaporation to give the target product 4'-chloro-4-amino-diphenyl ether.

References

[1] Green Chemistry, 2017, vol. 19, # 14, p. 3400 - 3407
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1588 - 1592
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4811 - 4815
[4] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80
[5] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80

4-Amino-4'-chlorodiphenyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Amino-4'-chlorodiphenyl ether manufacturers

Career Henan Chemical Co
Product
4-Amino-4'-chlorodiphenyl ether 101-79-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

101-79-1, 4-Amino-4'-chlorodiphenyl etherRelated Search:

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  • C12H10NOCl
  • C12H10ClNO
  • ARYL AMINE
  • Reagent for High-Performance Polymer Research
  • Diphenyl Ethers (for High-Performance Polymer Research)
  • API Intermediate
  • Benzene series
  • Biphenyl & Diphenyl ether
  • Amines
  • C11 to C38
  • Nitrogen Compounds
  • Diphenyl Ethers (for High-Performance Polymer Research)
  • Functional Materials
  • Reagent for High-Performance Polymer Research