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Isobutyramide

Product Name
Isobutyramide
CAS No.
563-83-7
Chemical Name
Isobutyramide
Synonyms
IBA;Propanamide, 2-methyl-;2-methylpropanamide isobutyramide;2-Methyl-propanamide;VX 366;Butyl aMide;Isobuytramide;ISOBUTYRAMIDE;isobutyric amide;Isobutyramide>
CBNumber
CB8344674
Molecular Formula
C4H9NO
Formula Weight
87.12
MOL File
563-83-7.mol
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Isobutyramide Property

Melting point:
127-131 °C (lit.)
Boiling point:
216-220 °C (lit.)
Density 
1.013 g/mL at 25 °C (lit.)
refractive index 
1.4345 (estimate)
Flash point:
216-220°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Sparingly), DMSO (Slightly)
form 
Solid
pka
16.60±0.50(Predicted)
color 
White to Off-White
Water Solubility 
Soluble in water.
LogP
0.003 (est)
CAS DataBase Reference
563-83-7(CAS DataBase Reference)
NIST Chemistry Reference
Propanamide, 2-methyl-(563-83-7)
EPA Substance Registry System
Propanamide, 2-methyl- (563-83-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
TX1475000
TSCA 
Yes
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
144436
Product name
Isobutyramide
Purity
99%
Packaging
25g
Price
$71.4
Updated
2024/03/01
Sigma-Aldrich
Product number
144436
Product name
Isobutyramide
Purity
99%
Packaging
100g
Price
$186
Updated
2024/03/01
TCI Chemical
Product number
I0102
Product name
Isobutyramide
Purity
>98.0%(GC)
Packaging
25g
Price
$55
Updated
2024/03/01
TCI Chemical
Product number
I0102
Product name
Isobutyramide
Purity
>98.0%(GC)
Packaging
500g
Price
$635
Updated
2024/03/01
Alfa Aesar
Product number
B21641
Product name
Isobutyramide, 99%
Packaging
25g
Price
$58.65
Updated
2024/03/01
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Isobutyramide Chemical Properties,Usage,Production

Chemical Properties

white needle-like crystalline powder

Uses

Isobutyramide could be a useful compound for technical applications as a component in environmentally-friendly automobile welding anti-spatter liquid.

Uses

Isobutyramide plays an important role in chemical grafting of human serum albumin during the synthesis of sequentially assembled protein capsules. It is used in pharmaceutical manufacturing and in cellular differentiation. It finds application in the transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. Further, it is in the treatment of beta-thalassemia and sickle cell disease.

Definition

ChEBI: Isobutyramide is a carboximidic acid.

Application

Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules.
Isobutyramide plays an important role in chemical grafting of human serum albumin during the synthesis of sequentially assembled protein capsules. It is used in pharmaceutical manufacturing and in cellular differentiation. It finds application in the transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. Further, it is in the treatment of beta-thalassemia and sickle cell disease.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2058, 1947 DOI: 10.1021/ja01200a070

Biochem/physiol Actions

Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. It is useful in the treatment of β-thalassemia and sickle cell disease.

Purification Methods

Crystallise the amide from acetone, *benzene, CHCl3, EtOAc or water, then dry it under vacuum over P2O5 or 99% at H2SO4, or at 70o/3hours in a desiccator. Sublime it under vacuum. [Kent & McAlvain Org Synth Coll Vol III 491 1955, Beilstein 2 H 293, 2 I 129, 2 II 262, 2 III 654, 2 IV 852.]

Isobutyramide Preparation Products And Raw materials

Raw materials

Preparation Products

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Isobutyramide Suppliers

TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
FUJIFILM Wako Pure Chemical Corporation
Tel
--
Fax
--
Email
ffwk-cservice@fujifilm.com
Country
Japan
ProdList
6222
Advantage
58
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
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View Lastest Price from Isobutyramide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Isobutyramide 563-83-7
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-03
Hebei Weibang Biotechnology Co., Ltd
Product
Isobutyramide 563-83-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Hebei Mojin Biotechnology Co., Ltd
Product
Isobutyramide 563-83-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-24

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