Norepinephrine

Product Name: Norepinephrine
CAS No.: 51-41-2
Chemical Name: Norepinephrine
Synonyms: NORADRENALINE;L-NORADRENALINE;NORADRENALIN;levophed;adrenor;aktamin;norartrinal;levoarterenol;(?)-Norepinephrine;arterenolfreebase(noradrenaline)
CBNumber: CB8346810
Molecular Formula: C8H11NO3
Formula Weight: 169.18
MOL File: 51-41-2.mol

More

Less

Norepinephrine Property

Melting point:: 220-230°C
alpha: D25 -37.3° (c = 5 in water with 1 equiv HCl)
Boiling point:: 298.46°C (rough estimate)
Density: 1.2435 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: 2-8°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly)
pka: 8.64(at 25℃)
form: crystalline
color: off-white to tan
optical activity: D +37.426 (c 5, H2O+HCl)L -37.1325 (c 5, H2O+HCl)
Water Solubility: Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether.
Sensitive: Air & Light Sensitive
Merck: 14,6695
BRN: 4231961
Stability:: Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃.
CAS DataBase Reference: 51-41-2(CAS DataBase Reference)
EPA Substance Registry System: Norepinephrine (51-41-2)

More

Less

Safety

Hazard Codes: T+,C,F
Risk Statements: 26/27/28-34-11-28
Safety Statements: 28-36/37-45-36/37/39-26-16-20
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: DN5950000
F: 8-10-23
HazardClass: 6.1
PackingGroup: II
HS Code: 29225090
Hazardous Substances Data: 51-41-2(Hazardous Substances Data)
Toxicity: dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7257
Product name: (?)-Norepinephrine
Purity: ≥98%, crystalline
Packaging: 1g
Price: $417
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7257
Product name: (?)-Norepinephrine
Purity: ≥98%, crystalline
Packaging: 5g
Price: $1500
Updated: 2024/03/01

Alfa Aesar

Product number: L08087
Product name: L-Noradrenaline, 98%
Packaging: 1g
Price: $359
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7257
Product name: (?)-Norepinephrine
Purity: ≥98%, crystalline
Packaging: 500mg
Price: $228
Updated: 2024/03/01

TRC

Product number: N661038
Product name: L-Noradrenaline
Packaging: 1g
Price: $265
Updated: 2021/12/16

More

Less

Norepinephrine Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Vascular active drug resistance to shock

Uses

An adrenergic neurotransmitter.

Uses

Norepinephrine is used for increasing cardiac constriction and for the necessary elevation of blood pressure after sharp decline, which can result from surgical intervention or trauma.

Definition

ChEBI: The R-enantiomer of noradrenaline.

brand name

Levophed (Hospira);Noradrec;Xylotox.

World Health Organization (WHO)

Vasoconstrictor agents have been in use for many years to prolong duration of action of local anaesthetics, particularly in dentistry. Combination products containing epinephrine or levarterenol in concentrations of 1:80,000 or less remain widely available. See also WHO comment for epinephrine.

Biological Functions

Most central noradrenergic neurons are located in the nucleus locus ceruleus of the pons and in neurons of the reticular formation. Fibers from these nuclei innervate a large number of cortical, subcortical, and spinomedullary fields. Many functions have been ascribed to the central noradrenergic neurons, including a role in affective disorders (see Chapter 33), in learning and memory, and in sleep–wake cycle regulation.The mammalian CNS contains both α- and β-adrenoceptors.

General Description

Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities.

Hazard

May cause local tissue necrosis, headache, bradycardia, hypertension; poison; teratogen; mutagen.

Biochem/physiol Actions

Adrenergic neurotransmitter

Pharmacology

Norepinephrine is the primary neurotransmitter produced and released by adrenergic neurons, and in literature it is also described as and called () noradrenaline or levarterenol. This vasopressor catecholamine reduces both the resistance and capacity of blood vessels by stimulating α-adrenoreceptors and having a direct cardiostimulatory effect, which is accomplished by activation of β1-adrenoreceptors. Norepinephrine exhibits significantly less activity than epinephrine as a drug for widening blood vessels through the activation of β2-adrenoreceptors. Elevation of both stylistic and diastolic blood pressure is a typical reaction to intravenous introduction of norepinephrine.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A sympathomimetic vasopressor. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Norepinephrine, L-1-(3,4-dihydroxyphenyl)-2-aminoethanol (11.1.4), is synthesized by two methods starting from 3,4-dihydroxybenzaldehyde. According to the first method, the indicated aldehyde is transformed into the cyanohydrin (11.1.3) by reaction with hydrogen cyanide, which is then reduced into norepinephrine (11.1.5).

The second method consists of the condensation of diacetate of the same aldehyde with nitromethane, which forms (3,4-diacetoxyphenyl)-2-nitroethanol (11.1.5). Then the nitro group is reduced and the product (11.1.6) is hydrolyzed into the desired norepinephrine (11.1.4) [4,9,13,14].

Purification Methods

Recrystallise adrenor from EtOH and store it in the dark under N2. [pKa, Lewis Brit J Pharmacol Chemother 9 488 1954, UV: Bergstr.m et al. Acta Physiol Scand 20 101 1950, Fluorescence: Bowman et al. Science NY 122 32 1955, Tullar J Am Chem Soc 70 2067 1948.] The L-tartrate salt monohydrate has m 102-104.5o, [] D -11o (c 1.6, H2O), after recrystallisation from H2O or EtOH. [Beilstein 13 III 2382.]

Norepinephrine Preparation Products And Raw materials

Raw materials

D(+)-Glucose Starch

Preparation Products

Abamectin

More

Less

Norepinephrine Suppliers

China 225 Czech 1 Czech Republic 1 Europe 2 Germany 4 India 18 Japan 1 Switzerland 3 United Kingdom 10 United States 40 Global 305

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38630
Advantage: 58

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

IsoSciences

Tel: --
Fax: --
Email: info@isosciences.com
Country: United States
ProdList: 379
Advantage: 58

Selleck Chemicals LLC

Tel: --
Fax: --
Email: sales@selleckchem.com
Country: United States
ProdList: 1848
Advantage: 58

MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)

Tel: --
Fax: --
Email: serv@mpbio.com
Country: United States
ProdList: 1854
Advantage: 58

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

RIA International LLC

Tel: --
Fax: --
Email: marketing@riausa.net
Country: United States
ProdList: 1324
Advantage: 50

Rintech, Inc.

Tel: --
Fax: --
Email: info@rintechinc.com
Country: United States
ProdList: 3416
Advantage: 60

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

API, Inc.

Tel: --
Fax: --
Email: HenryNiemczyk@apiincnj.com
Country: United States
ProdList: 118
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

TimTec Corporation

Tel: --
Fax: --
Country: United States
ProdList: 1945
Advantage: 58

SynFine Research

Tel: --
Fax: --
Email: research@synfine.com
Country: United States
ProdList: 1024
Advantage: 68

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Allichem LLC

Tel: --
Fax: --
Email: lib@umbi.umd.edu
Country: United States
ProdList: 749
Advantage: 30

Pfaltz & Bauer, Inc.

Tel: --
Fax: --
Email: sales@pfaltzandbauer.com
Country: United States
ProdList: 6828
Advantage: 72

Upstate

Tel: --
Fax: --
Email: info@upstate.com
Country: United States
ProdList: 876
Advantage: 76

Perkin Elmer Life Sciences Inc.

Tel: --
Fax: --
Email: techsupport@nen.com
Country: United States
ProdList: 1296
Advantage: 86

Advanced Targeting Systems

Tel: --
Fax: --
Email: ats@atsbio.com
Country: United States
ProdList: 71
Advantage: 71

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

Zymed Laboratories Inc.

Tel: --
Fax: --
Country: United States
ProdList: 3068
Advantage: 86

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

More

Less

View Lastest Price from Norepinephrine manufacturers

Hebei Junhua Import and Export Co., LTD

Product: Norepinephrine 51-41-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2025-02-26

Hebei Junhua Import and Export Co., LTD

Product: Norepinephrine 51-41-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 1000
Release date: 2025-02-27

Sinoway Industrial co., ltd.

Product: Norepinephrine 51-41-2
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 0.99
Supply Ability: 20 tons
Release date: 2024-06-27

51-41-2, NorepinephrineRelated Search:

2-(METHYLSULFONYL)ETHANOL Hydroquinone 1-Hydroxyethylidene-1,1-diphosphonic acid 3-Diethylaminophenol Tris(hydroxymethyl)aminomethane Catechol Resorcinol tert-Butylhydroquinone 3-Aminophenol ALTRENOGEST 6-Aminocaproic acid 4-tert-Butylcatechol Glycine NOREPINEPHRINE BITARTRATE,L-NOREPINEPHRINE BITARTRATE,L-(-)-NOREPINEPHRINE-(+)-BITARTRATE,NORADRENALINE,L-NORADRENALINE BITARTRATE,noradrenaline,tartrate(1:1 Isoproterenol 4,6,7-Isoquinolinetriol, 1,2,3,4-tetrahydro- Norepinephrine Impurity 23 Norepinephrine Impurity 2 Noradrenalin Noradrenaline

(-)-alpha-(aminomethyl)protocatechuylalcohol

(-)-noradrec

4-(2-amino-1-hydroxyethyl)-2-benzenedio(r)-

adrenor

Adrenaline Impurity 2（Adrenaline EP Impurity B）

aktamin

arterenolfreebase(noradrenaline)

d-(-)-noradrenaline

l-1-(3,4-dihydroxyphenyl)-2-aminoethanol

l-2-amino-1-(3,4-dihydroxyphenyl)ethanol

l-3,4-dihydroxyphenylethanolamine

l-alpha-(aminomethyl)-3,4-dihydroxybenzylalcohol

levoarterenol

levonoradrenaline

levonorepinephrine

levophed

noradrenalina

noradrenline

norartrinal

norepirenamine

sympathine

L-NOREPINEPHRINE

L-NORADRENALINE

LEVARTERENOL

L-ARTERENOL

(-)-ARTERENOL

ARTERENOL (-)-

(R)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL

NORADRENALIN

(-)-NORADRENALINE

NORADRENALINE

(-)-NOREPINEPHRINE

NOREPINEPHRINE

l-arternol

4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol

(-)-a-(Aminomethyl)protocatechuyl alcohol

(R)-(-)-Norepinephrine

(R)-Norepinephrine

1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-

1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- (9CI)

l-a-(Aminomethyl)-3,4-dihydroxybenzyl alcohol

Nor-Epirenan

L-Arternol=L-Norepinephrine

(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol

4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol

Epinephrine Impurity B

Noradrenaline(Norepinephrine,NA,NE)

()-Norepinephrine,(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol

Noradrenaline API

Norepinephrine Hydrochloride (Solution)

Norepinephrine HCl (solution)

-NoradrenaL

Norepinephrine USP/EP/BP

Norepinephrine (Noradrenaline)

Norepinephrine USP

(?)-Norepinephrine

SSXS-2

(R)-Norepinephrine,L-Norepinephrine