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NOLADIN ETHER

Product Name
NOLADIN ETHER
CAS No.
222723-55-9
Chemical Name
NOLADIN ETHER
Synonyms
HU 310;2-AG ETHER;Noladineether;NOLADIN ETHER;2-O-arachidonylglycerol;2-ARACHIDONYL GLYCEROL ETHER;2-ARACHIDONYL GLYCERYL ETHER;5Z,8Z,11Z,14Z-EICOSATETRAEN-2-GLYCERYL ETHER;2-[(5Z,8Z,11Z,14Z)-EICOSATETRAENYLOXY]-1,3-PROPANEDIOL;2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]propane-1,3-diol
CBNumber
CB8350967
Molecular Formula
C23H40O3
Formula Weight
364.56
MOL File
222723-55-9.mol
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NOLADIN ETHER Property

Boiling point:
488.9±45.0 °C(Predicted)
Density 
0.948±0.06 g/cm3(Predicted)
Flash point:
14℃
storage temp. 
Desiccate at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 500 μg/ml
pka
13.92±0.10(Predicted)
form 
ethanol solution (10 mg/mL (1% w/v))
color 
colorless to light yellow
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Safety

Hazard Codes 
F
Risk Statements 
11
Safety Statements 
7-16
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0473
Product name
Noladin ether
Purity
≥98% (HPLC)
Packaging
5mg
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0473
Product name
Noladin ether
Purity
≥98% (HPLC)
Packaging
25mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
62165
Product name
2-Arachidonyl Glycerol ether
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
62165
Product name
2-Arachidonyl Glycerol ether
Purity
≥98%
Packaging
5mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
62165
Product name
2-Arachidonyl Glycerol ether
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
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NOLADIN ETHER Chemical Properties,Usage,Production

Description

2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay). It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively. 2-AG ether displays the typical tetrad of CB activities in mice. It is more chemically stable than 2-AG , with an endogenous half-life of hours rather than minutes. However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses. 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 μg per eye. It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork. Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.

Uses

HU 310 is an endogenous GPR55 and CB1 receptors agonist. HU 310 has been shown to induce hyperglycia in rats. HU 310 can be used to investigate the biological roles of GPR55 and CB1 receptors.

Definition

ChEBI: A monoalkylglycerol that is the 2-O-arachidonyl derivative of glycerol.

Biological Activity

Endogenous agonist for the GPR55 and CB 1 receptors (EC 50 values are 10 and 37 nM respectively) that displays selectivity over CB 2 receptors (K i values are 21.2 nM and > 3mM at CB 1 and CB 2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo . Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55. Also available as part of the Endocannabinoid Tocriset™ .

NOLADIN ETHER Preparation Products And Raw materials

Raw materials

Preparation Products

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NOLADIN ETHER Suppliers

China 28 Germany 2 Italy 1 Switzerland 2 United Kingdom 1 United States 9 Global 43
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
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58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4933
Advantage
58
SHANGHAI ZZBIO CO., LTD.
Tel
15102117276 19921389125
Email
tech@zzbioco.com
Country
China
ProdList
12065
Advantage
58

222723-55-9, NOLADIN ETHERRelated Search:

1-OCTADECANOYL-2-[(CIS,CIS,CIS,CIS)-5,8,11,14-EICOSATETRAENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DI5,8,11,14(ALL-CIS)EICOSATETRAENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 2-AG-D5 1-STEAROYL-2-ARACHIDONOYL-SN-GLYCEROL 2-AG 1-O-HEXADECYL-2-ARACHIDONYL-SN-GLYCERO-3-PHOSPHOCHOLINE 2-AG-D8 NOLADIN ETHER 1-STEAROYL-2-ARACHIDONOYL-PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE, (NA+ SALT) TRIARACHIDONIN PHOSPHATIDYLCHOLINE, L-ALPHA-1-STEAROYL-2-ARACHIDONYL, [ARACHIDONYL-5,6,8,9,11,12,14,15-3H(N)] 2-ARACHIDONYL GLYCEROL [ARACHIDONYL 5,6,8,9,11,12,14,15-3H(N)] 3-STERAOYL-2-ARACHIDONYL-SN-GLYCEROL PHOSPHATIDYLCHOLINE, L-ALPHA-1-PALMITOYL-, 2-ARACHIDONYL, [ARACHIDONYL-1-14C] PHOSPHATIDYLCHOLINE, L-ALPHA-1-O HEXADECYL-1-2-ARACHIDONYL, [ARACHIDONYL-5,6,8,9,11,12,14,15-3H(N)] PHOSPHATIDYLETHANOLAMINE, L-ALPHA-1-PALMITOYL, 2-ARACHIDONYL, [ARACHIDONYL-1-14C] 1-STEAROYL-2-[1-14C]ARACHIDONYL-SN-GLYCEROL L-3-PHOSPHATIDYLCHOLINE,1-STEAROYL-2-[1-14C]ARACHIDONYL

  • 2-[(5Z,8Z,11Z,14Z)-EICOSATETRAENYLOXY]-1,3-PROPANEDIOL
  • 2-AG ETHER
  • 2-ARACHIDONYL GLYCERYL ETHER
  • 2-ARACHIDONYL GLYCEROL ETHER
  • 5Z,8Z,11Z,14Z-EICOSATETRAEN-2-GLYCERYL ETHER
  • NOLADIN ETHER
  • Noladineether
  • 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yloxy]-1,3-propanediol
  • HU 310
  • 2-O-arachidonylglycerol
  • 2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]propane-1,3-diol
  • 1,3-Propanediol, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yloxy]-
  • 222723-55-9
  • C23H40O3
  • Cannabinoid receptor