4-Amino-3-chlorobenzoic acid
- Product Name
- 4-Amino-3-chlorobenzoic acid
- CAS No.
- 2486-71-7
- Chemical Name
- 4-Amino-3-chlorobenzoic acid
- Synonyms
- BUTTPARK 29\06-53;4-Amino-3-chlorobe;RARECHEM AL BO 0579;Curcumin Impurity 6;4-Amino-3-chlorobenz;3-chloro-4-aminobenzoate;4-Carboxy-2-chloroaniline;4-AMINO-3-CHLORBENZOIC ACID;4-Amino-3-chlorobenzioc acid;3-CHLORO-4-AMINOBENZOIC ACID
- CBNumber
- CB8352668
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 2486-71-7.mol
4-Amino-3-chlorobenzoic acid Property
- Melting point:
- 228 °C
- Boiling point:
- 341.2±27.0 °C(Predicted)
- Density
- 1.476±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 4.49±0.10(Predicted)
- color
- White to Orange to Green
- CAS DataBase Reference
- 2486-71-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 691445
- Product name
- 4-Amino-3-chlorobenzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $33.8
- Updated
- 2023/06/20
- Product number
- 691445
- Product name
- 4-Amino-3-chlorobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $82
- Updated
- 2023/06/20
- Product number
- A1971
- Product name
- 4-Amino-3-chlorobenzoic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- A602845
- Product name
- 4-Amino-3-chlorobenzoic Acid
- Packaging
- 25g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 066862
- Product name
- 4-Amino-3-chlorobenzoic acid
- Purity
- 97%97%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
4-Amino-3-chlorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
4-?Amino-?3-?chlorobenzoic Acid is a reagent used in the synthesis of orally bioavailable 1H-Pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase MPS1which is overexpressed in cancer cell lines.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
84228-44-4
2486-71-7
General procedure for the synthesis of 3-chloro-4-aminobenzoic acid from methyl 4-amino-3-chlorobenzoate: 1. Saponification reaction: 4-amino-3-chlorobenzoic acid methyl ester (21.6 mmol) was dissolved in ethanol (25 mL) and 1M NaOH aqueous solution (25 mL), and heated to reflux for 2 hours. 2. Post-treatment: after completion of the reaction, the organic solvent was removed by evaporation and the pH of the reaction solution was adjusted to 4 with acid. 3. Isolation and purification: The precipitate was collected by filtration, washed with water and subsequently dried under vacuum to obtain the target product 3-chloro-4-aminobenzoic acid. Yield: 92%. 1H NMR (D6-DMSO) δ: 6.15 (s, 2H), 6.79 (d, 1H), 7.59 (dd, 1H), 7.71 (d, 1H), 12.37 (br s, 1H).
References
[1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 25
[2] Patent: WO2006/114093, 2006, A1. Location in patent: Page/Page column 37
4-Amino-3-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-3-chlorobenzoic acid Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
- 6184
- Advantage
- 60
- Tel
- --
- Fax
- --
- info@manchesterorganics.com
- Country
- United Kingdom
- ProdList
- 6834
- Advantage
- 67
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
- --
- Fax
- --
- enquiry@leancare.co.uk
- Country
- United Kingdom
- ProdList
- 6446
- Advantage
- 42
- Tel
- --
- Fax
- --
- sales@etascientific.com
- Country
- United Kingdom
- ProdList
- 6090
- Advantage
- 34
- Tel
- --
- Fax
- --
- Country
- United Kingdom
- ProdList
- 6309
- Advantage
- 46
- Tel
- --
- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- Country
- United Kingdom
- ProdList
- 6565
- Advantage
- 38
- Tel
- --
- Fax
- --
- 113707.50@compuserve.com
- Country
- United Kingdom
- ProdList
- 6078
- Advantage
- 30
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
- 6807
- Advantage
- 42
- Tel
- --
- Fax
- --
- sales@ubichem.com
- Country
- United Kingdom
- ProdList
- 1567
- Advantage
- 65
View Lastest Price from 4-Amino-3-chlorobenzoic acid manufacturers
- Product
- 4-Amino-3-chlorobenzoic acid 2486-71-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02