4-Amino-3-chlorobenzoic acid

Product Name: 4-Amino-3-chlorobenzoic acid
CAS No.: 2486-71-7
Chemical Name: 4-Amino-3-chlorobenzoic acid
Synonyms: BUTTPARK 29\06-53;4-Amino-3-chlorobe;RARECHEM AL BO 0579;Curcumin Impurity 6;4-Amino-3-chlorobenz;3-chloro-4-aminobenzoate;4-Carboxy-2-chloroaniline;4-AMINO-3-CHLORBENZOIC ACID;4-Amino-3-chlorobenzioc acid;3-CHLORO-4-AMINOBENZOIC ACID
CBNumber: CB8352668
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 2486-71-7.mol

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4-Amino-3-chlorobenzoic acid Property

Melting point:: 228 °C
Boiling point:: 341.2±27.0 °C(Predicted)
Density: 1.476±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.49±0.10(Predicted)
color: White to Orange to Green
CAS DataBase Reference: 2486-71-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 691445
Product name: 4-Amino-3-chlorobenzoic acid
Purity: 97%
Packaging: 1g
Price: $33.8
Updated: 2023/06/20

Sigma-Aldrich

Product number: 691445
Product name: 4-Amino-3-chlorobenzoic acid
Purity: 97%
Packaging: 5g
Price: $82
Updated: 2023/06/20

TCI Chemical

Product number: A1971
Product name: 4-Amino-3-chlorobenzoic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $95
Updated: 2025/07/31

TRC

Product number: A602845
Product name: 4-Amino-3-chlorobenzoic Acid
Packaging: 25g
Price: $170
Updated: 2021/12/16

Matrix Scientific

Product number: 066862
Product name: 4-Amino-3-chlorobenzoic acid
Purity: 97%97%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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4-Amino-3-chlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

4-?Amino-?3-?chlorobenzoic Acid is a reagent used in the synthesis of orally bioavailable 1H-Pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase MPS1which is overexpressed in cancer cell lines.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

84228-44-4

2486-71-7

General procedure for the synthesis of 3-chloro-4-aminobenzoic acid from methyl 4-amino-3-chlorobenzoate: 1. Saponification reaction: 4-amino-3-chlorobenzoic acid methyl ester (21.6 mmol) was dissolved in ethanol (25 mL) and 1M NaOH aqueous solution (25 mL), and heated to reflux for 2 hours. 2. Post-treatment: after completion of the reaction, the organic solvent was removed by evaporation and the pH of the reaction solution was adjusted to 4 with acid. 3. Isolation and purification: The precipitate was collected by filtration, washed with water and subsequently dried under vacuum to obtain the target product 3-chloro-4-aminobenzoic acid. Yield: 92%. 1H NMR (D6-DMSO) δ: 6.15 (s, 2H), 6.79 (d, 1H), 7.59 (dd, 1H), 7.71 (d, 1H), 12.37 (br s, 1H).

References

[1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 25
[2] Patent: WO2006/114093, 2006, A1. Location in patent: Page/Page column 37

4-Amino-3-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-3-chlorobenzoic acid Suppliers

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View Lastest Price from 4-Amino-3-chlorobenzoic acid manufacturers

Career Henan Chemical Co

Product: 4-Amino-3-chlorobenzoic acid 2486-71-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-01-02

2486-71-7, 4-Amino-3-chlorobenzoic acidRelated Search:

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RARECHEM AL BO 0579

BUTTPARK 29\06-53

4-Amino-3-chlorobenzoic acid 97%

4-Carboxy-2-chloroaniline

4-AMino-3-chlorobenzoic Acid, 97+%

3-chloro-4-aminobenzoate

4-AMNIO-3-CHLOROBENZIOC ACID

4-AMINO-3-CHLOROBENZOIC ACID

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3-CHLORO-4-AMINOBENZOIC ACID

4-Amino-3-chlorobenzioc acid

4-Amino-3-chlorobenz

4-Amino-3-chlorobe

4-Amino-3-chlorobenzoic acid >99%

4-Amino-3-chlorobenzoic Acid &gt

Benzoic acid, 4-amino-3-chloro-

4-Amino-3-chlorobenzoic acid USP/EP/BP

2486-71-7 98%MIN 4-Amino-3-chlorobenzoic acid factory

Curcumin Impurity 6

2486-71-7

C7H6CINO2

API Intermediate

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

pharmacetical

Phenylacetic acid

Miscellaneous

Benzenes

Aromatic Amino AcidsCarbonyl Compounds

C7

Carboxylic Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives