D-Serine methyl ester hydrochloride
- Product Name
- D-Serine methyl ester hydrochloride
- CAS No.
- 5874-57-7
- Chemical Name
- D-Serine methyl ester hydrochloride
- Synonyms
- METHYL D-SERINATE HYDROCHLORIDE;D-Serine Methyl Ester HCl;(R)-Methyl 2-Amino-3-hydroxypropanoate Hydrochloride;D-Ser-OMe.HCl;H-D-SER-OME HCL;H-D-Ser-OMe.HCI;D-SERINE-OME HCL;D-Serine methyl este;Cycloserine Impurity 12;Cycloserine Impurity 2 HCl
- CBNumber
- CB8354930
- Molecular Formula
- C4H10ClNO3
- Formula Weight
- 155.58
- MOL File
- 5874-57-7.mol
D-Serine methyl ester hydrochloride Property
- Melting point:
- 163-166 °C(lit.)
- alpha
- -4 º (c=4 in ethanol)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in ethanol and methanol.
- form
- Liquid
- color
- Clear colorless to yellow
- optical activity
- [α]20/D 4°, c = 4 in ethanol
- InChI
- InChI=1/C4H9NO3.ClH/c1-8-4(7)3(5)2-6;/h3,6H,2,5H2,1H3;1H/t3-;/s3
- InChIKey
- NDBQJIBNNUJNHA-AENDTGMFSA-N
- SMILES
- [C@@H](N)(CO)C(=O)OC.Cl |&1:0,r|
- CAS DataBase Reference
- 5874-57-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29225000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 445797
- Product name
- D-Serine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $26.85
- Updated
- 2025/07/31
- Product number
- 445797
- Product name
- D-Serine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $50.4
- Updated
- 2025/07/31
- Product number
- S0553
- Product name
- H-D-Ser-OMe·HCl
- Packaging
- 25G
- Price
- $72
- Updated
- 2025/07/31
- Product number
- S0553
- Product name
- H-D-Ser-OMe·HCl
- Packaging
- 100G
- Price
- $178
- Updated
- 2025/07/31
- Product number
- 289048
- Product name
- D-Serine methyl ester HCl
- Packaging
- 25g
- Price
- $333
- Updated
- 2021/12/16
D-Serine methyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
D-Serine Methyl Ester Hydrochloride (cas# 5874-57-7) is a compound useful in organic synthesis.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
312-84-5
5874-57-7
General procedure for the synthesis of D-serine methyl ester hydrochloride from methanol and D-serine: 4.2.1.1 Synthesis of methyl (R)-2-isopropyl-4,5-dihydrooxazole-4-carboxylate First, sulfoxide chloride (SOCl?, 7.60 mL, 104.2 mmol) was slowly added dropwise to a methanolic solution of D-serine (10.0 g, 95.1 mmol) and the reaction mixture was stirred for 24 h at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator to give a white solid. The solid was washed with hexane (3 x 25 mL) to give D-serine methyl ester hydrochloride (14.4 g, 97% yield) as a colorless solid. The product was characterized by 1H NMR (300 MHz, D?O) with the following chemical shifts: δ 4.32-4.28 (1H, m, CH), 4.12 (1H, dd, J = 4.2, 12.5 Hz, CHaHbOH), 4.02 (1H, dd, J = 3.4, 12.5 Hz, CHaHbOH), 3.88 (3H, s, CH?) .
References
[1] Journal of Organic Chemistry, 1997, vol. 62, # 2, p. 372 - 376
[2] Heterocyclic Communications, 2005, vol. 11, # 3-4, p. 343 - 346
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5716 - 5726
[4] Chemical Communications, 2016, vol. 52, # 55, p. 8612 - 8614
[5] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10162 - 10165
D-Serine methyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-Serine methyl ester hydrochloride manufacturers
- Product
- D-Serine methyl ester hydrochloride 5874-57-7
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2021-10-08
- Product
- D-Ser-OMe·HCl 5874-57-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-08
- Product
- D-Serine methyl ester hydrochloride 5874-57-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-22