ChemicalBook > CAS DataBase List > 1,2,4-Benzenetriol

1,2,4-Benzenetriol

Product Name
1,2,4-Benzenetriol
CAS No.
533-73-3
Chemical Name
1,2,4-Benzenetriol
Synonyms
1,2,4-TRIHYDROXYBENZENE;Benzene-1,2,4-triol;HYDROXYHYDROQUINONE;1,2,4-Benzentril;Phloroglucinol Impurity 5;HHQ;NSC 2818;Oxyhydrochinon;OXYHYDROQUINONE;4-Hydroxycatechol
CBNumber
CB8356419
Molecular Formula
C6H6O3
Formula Weight
126.11
MOL File
533-73-3.mol
More
Less

1,2,4-Benzenetriol Property

Melting point:
140 °C (subl.) (lit.)
Boiling point:
194.21°C (rough estimate)
Density 
1.45 g/cm3 (20℃)
refractive index 
1.5627 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
9.58±0.10(Predicted)
color 
Plates from Et2O
Water Solubility 
freely soluble
Sensitive 
Air Sensitive
Merck 
14,1073
BRN 
2042863
Stability:
Light Sensitive, Moisture Sensitive
CAS DataBase Reference
533-73-3(CAS DataBase Reference)
NIST Chemistry Reference
1,2,4-Benzenetriol(533-73-3)
EPA Substance Registry System
1,2,4-Benzenetriol (533-73-3)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38-20/21/22
Safety Statements 
26-39-36/37/39-22
WGK Germany 
3
RTECS 
DC4200000
Hazard Note 
Irritant/Keep Cold/Air Sensitive
TSCA 
Yes
HS Code 
2907 29 00
Toxicity
oms-hmn:lym 50 mmol/L CNREA8 45,2471,85
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.43791
Product name
1,2,4-Trihydroxybenzene
Purity
for synthesis
Packaging
5G
Price
$196
Updated
2024/03/01
Sigma-Aldrich
Product number
8.43791
Product name
1,2,4-Trihydroxybenzene
Purity
for synthesis
Packaging
25g
Price
$439
Updated
2024/03/01
Sigma-Aldrich
Product number
173401
Product name
1,2,4-Benzenetriol
Purity
ReagentPlus , 99%
Packaging
1g
Price
$89.1
Updated
2024/03/01
Sigma-Aldrich
Product number
173401
Product name
1,2,4-Benzenetriol
Purity
ReagentPlus , 99%
Packaging
5g
Price
$306
Updated
2024/03/01
TCI Chemical
Product number
H0249
Product name
1,2,4-Trihydroxybenzene
Purity
>98.0%(GC)
Packaging
10g
Price
$138
Updated
2024/03/01
More
Less

1,2,4-Benzenetriol Chemical Properties,Usage,Production

Chemical Properties

Gray powder

Physical properties

1,2,4-Benzenetriol forms colorless platelets or prisms that quickly colorize in air. It is soluble in water and polar solvents, and slightly soluble in chloroform and carbon disulfide.

Uses

1,2,4-Trihydroxybenzene is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.It is used as a metabolite of benzene.

Definition

ChEBI: Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.

Production Methods

1,2,4-Benzenetriol is synthesized by hydrolysis of 1,2,4-triacetoxybenzene, which is prepared by the acid-catalyzed reaction of p-benzoquinone with acetic anhydride.
Other production methods for 1,2,4-Benzenetriol are oxidation of resorcinol with hydrogen peroxide and Dakin oxidation of 2,4- or 3,4-dihydroxybenzaldehydes or 2,4- or 3,4-dihydroxyacetophenones with alkaline hydrogen peroxide solution.

General Description

1,2,4-Benzenetriol is also known as hydroxyhydroquinone. It is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.

Chemical Reactivity

1,2,4-Benzenetriol is, like other phenols, a strong reducing agent. Its basic aqueous solution absorbs gaseous oxygen to produce black precipitates of the humic acid type. 1,2,4-Benzenetriol shows typical reactions of phenols. Derivatives of the tautomeric keto form are also known: halogenation of hydroxyhydroquinone, for example, gives 1,2,5,5-tetrahalocyclohexene-3,4,6-trione. Condensation with ethylacetoacetate produces dihydroxycoumarin; reaction with phthalic anhydride yields hydroxyhydroquinonephthalein. Monosubstitution of a hydroxy group by an amino group occurs easily at room temperature and gives 2,4-dihydroxyaniline.

Safety Profile

Poison by subcutaneous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise the triol from Et2O or Et2O/EtOH, and dry it in a vacuum. The picrate forms orange-red needles m 96o. [Beilstein 6 H 1087, 6 I 541, 6 II 1071, 6 III 6276.]

1,2,4-Benzenetriol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,2,4-Benzenetriol Suppliers

HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
Advantage
55
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
Ring Specialty Chemicals Inc.
Tel
--
Fax
--
Email
info@ringchemicals.com
Country
United States
ProdList
888
Advantage
39
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
ChemSampCo, Inc.
Tel
--
Fax
--
Email
sales@chemsampco.com
Country
United States
ProdList
3585
Advantage
60
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Fisher Scientific
Tel
--
Fax
--
Email
sales@fishersci.com
Country
United States
ProdList
2337
Advantage
86
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
More
Less

View Lastest Price from 1,2,4-Benzenetriol manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
1,2,4-Benzenetriol 533-73-3
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Longbang Technology Co., Ltd
Product
1,2,4-Benzenetriol 533-73-3
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-26
Hebei Jingbo New Material Technology Co., Ltd
Product
1,2,4-Benzenetriol 533-73-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000000
Release date
2023-12-25

533-73-3, 1,2,4-BenzenetriolRelated Search:


  • OXYHYDROQUINONE
  • 1,2,4-TRIHYDROXYBENZENE
  • 1,2,4-BENZENETRIOL
  • 1,3,4-Benzenetriol
  • 1,3,4-Trihydroxybenzene
  • 2,5-Dihydroxyphenol
  • 2-Hydroxy-1,4-hydroquinone
  • Hydroquinone, hydroxy-
  • hydroxy-hydroquinon
  • Oxyhydrochinon
  • HYDROXYHYDROQUINONE
  • Benzene-1,2,4-triol
  • 1,2,4-BENZENETRIOL 99%
  • 1,2,4-Trihydroxybenzene,99%
  • 1,2,4-Benzenetriol~Hydroxyhydroquinone
  • 1,2,4-Trihydroxybenzoic acid
  • 1,2,4-Benzentril
  • 1,2,4-Trihydroxybenzene 99%
  • Benzene-1,3,4-triol
  • 1,2,4-Benzenetriol,95%
  • 1,2,4-Benzenetriol,99%
  • 1,2,4-BENZENETRIOL (1,2,4-TRIHYDROXYBENZENE)
  • 2-Hydroxyhydroquinone
  • 2-Hydroxy-p-benzohydroquinone
  • 4-Hydroxycatechol
  • HHQ
  • NSC 2818
  • 1,2,4-TRIHYDROXYBENZENE / 1,2,4-BENZENETRIOL
  • 1,2,4-three benzenephenol
  • 1,2,4-Benzenetriol ReagentPlus(R), 99%
  • 1,2,4-Trihydroxybenzene, 95+%
  • 1,2,4-Trihydroxybene
  • 1,2,4-Benzenetriol Vetec(TM) reagent grade, 98%
  • 1,2,4-Trihydroxybenzene for synthesis
  • Phloroglucinol Impurity E
  • Phloroglucinol Impurity 5
  • 1,2,4-Trihydroxybenzene&gt
  • Phloroglucinol EP Impurity E
  • 1,2,4-Trihydroxybenzene (Paroxetine Impurity)
  • Paroxetine impurities780
  • 1,2,4-thihydroxy benzene hair dye intermediate
  • Phloroglucinol Impurity 5 (Phloroglucinol EP Impurity E)
  • 533-73-3
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • Aromatics Compounds
  • Aromatics
  • Metabolites & Impurities
  • bc0001