ChemicalBook > CAS DataBase List > Gomisin A

Gomisin A

Product Name: Gomisin A
CAS No.: 58546-54-6
Chemical Name: Gomisin A
Synonyms: D01752;TJN-101;GOMISIN A;Besigomsin;BESIGOMISIN;wuweizichunb;SCHIZANDROL B;SCHISANDROL B;wuweizialcoholb;Grifola frondsa
CBNumber: CB8374224
Molecular Formula: C23H28O7
Formula Weight: 416.47
MOL File: 58546-54-6.mol

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Gomisin A Property

Melting point:: 88.5°C
Boiling point:: 454.79°C (rough estimate)
Density: 1.1772 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: powder to crystal
pka: 14.58±0.40(Predicted)
color: White to Light yellow
biological source: Schisandra chinensis
LogP: 4.770 (est)

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Safety

Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1251
Product name: Gomisin A
Packaging: 5 mg
Price: $112.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1251
Product name: Gomisin A
Packaging: 25 mg
Price: $475
Updated: 2025/07/31

TCI Chemical

Product number: G0537
Product name: Gomisin A
Packaging: 5MG
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: G0537
Product name: Gomisin A
Packaging: 25MG
Price: $232
Updated: 2025/07/31

Cayman Chemical

Product number: 25149
Product name: Schisandrol B
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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Gomisin A Chemical Properties,Usage,Production

Description

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .

Chemical Properties

White powder

Uses

Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.

in vivo

Schisandrol B (12.5?-200?mg/kg; oral administration; seven times with an interval of 12?hours) pretreatment significantly attenuates the increases in alanine aminotransferase and aspartate aminotransferase activity, and prevents elevated hepatic malondialdehyde formation and the depletion of GSH in a dose-dependent manner. Schisandrol B abrogates APAP-induced activation of p53 and p21, and increases expression of liver regeneration and antiapoptotic-related proteins such as cyclin D1 (CCND1), PCNA, and BCL-2^[1].

Animal Model:	Male C57BL/6 mice (6-8 weeks old, 20-22?g) injected with Acetaminophen (APAP)^[1]
Dosage:	12.5?mg/kg, 12.5?mg/kg and 200?mg/kg
Administration:	Oral administration; seven times with an interval of 12?hours
Result:	Showed a protective effect against APAP-induced liver injury in mice.

IC 50

CYP2; CYP3A

References

[1] H. TAGUCHI Y I. The Constituents of Schizandra chinensis BAILL. I. The Structures of Gomisin A, B and C[J]. Chemical & pharmaceutical bulletin, 1975, 114 1: 3296-3298. DOI: 10.1248/cpb.23.3296
[2] HANG ZENG. Schisandrol B protects against cholestatic liver injury through pregnane X receptors[J]. British Journal of Pharmacology, 2017, 174 8: 672-688. DOI: 10.1111/bph.13729
[3] XI LI . Schisandrol B promotes liver regeneration after partial hepatectomy in mice[J]. European journal of pharmacology, 2018, 818: Pages 96-102. DOI: 10.1016/j.ejphar.2017.10.044
[4] YI-MING JIANG. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway[J]. Acta Pharmacologica Sinica, 2016, 37 3: 382-389. DOI: 10.1038/aps.2015.120

Gomisin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Gomisin A Suppliers

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View Lastest Price from Gomisin A manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Gomisin A 58546-54-6
Price: US $0.00-0.00/mg
Min. Order: 20mg
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2022-10-13

Shanghai Standard Technology Co., Ltd.

Product: Gomisin A 58546-54-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-15

Career Henan Chemical Co

Product: Gomisin A 58546-54-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

58546-54-6, Gomisin ARelated Search:

Gomisin C(Schisantherin A) Schisandrin A Nortropine GOMISIN N Schisandrin Silibinin Ginkgo biloba extract WUWEIZISU C (5S)-6α,7β-Dimethyl-1,2,3,11,12-pentamethoxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5α,6β,10-triol 5-benzoate 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)- Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer SCHISANTHERIN C 98+% HPLC Gomisin K3 GOMISIN,GOMISIN C SCHISANDROL B (GOMISIN A)(P),SCHISANDROL B(GOMISIN A) SNAP-N-SHOOT 0.1mg/mL(P),Gomisin A(Schisandrol B) Masoprocol Gomisin B(Schisantherin B) Dihydromyristicin

2,3,13-tetramethoxy-l-stereoisomer

benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy

wuweizialcoholb

wuweizichunb

BESIGOMISIN

GOMISIN A

SCHISANDROL B

SCHIZANDROL B

Besigomsin

Besigomsin (jan/inn)

D01752

Gomisin A/Schisandrin

(6S,7S)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6β,7β-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6α-ol

TJN-101

Schisandrol B (Gomisin-A

Schizandrol B, froM Schisandra chinensis

Schizandrol B, 98%, from Schisandra chinensis (Turcz.) Baill.

Gomisin A Standard

Grifola frondosa (Dicks.) Gray

Grifola frondsa

Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6S,7S,13aR)-

Schizandrol B，Gomisin A

(6S,7S)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol

(6S,7S,13aR)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol

(6S,7S,13aR)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol

Schisandrin ethyl alcohol

Schisandrol B-RM

Schisandrol B, 10 mM in DMSO

Schizandrol B - Bio-X ?

Schisandrol B ,Gomisin

58546-54-6

58546-54-8

C23H28O7

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

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