Clorsulon
- Product Name
- Clorsulon
- CAS No.
- 60200-06-8
- Chemical Name
- Clorsulon
- Synonyms
- chlorsulon;CLORSULON USP;orsuL;MK-401;l631529;curatrem;CLORSULON;keluosuolong;Clorsulon (MK-401;Clorsulon (200 mg)
- CBNumber
- CB8375438
- Molecular Formula
- C8H8Cl3N3O4S2
- Formula Weight
- 380.66
- MOL File
- 60200-06-8.mol
Clorsulon Property
- Melting point:
- 194-203°C
- Boiling point:
- 651.7±65.0 °C(Predicted)
- Density
- 1.800±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.16±0.60(Predicted)
- color
- White
- InChI
- InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
- InChIKey
- QOVTVIYTBRHADL-UHFFFAOYSA-N
- SMILES
- C1(S(N)(=O)=O)=C(/C(/Cl)=C(/Cl)\Cl)C=C(N)C(S(N)(=O)=O)=C1
- CAS DataBase Reference
- 60200-06-8(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 2
- RTECS
- CZ9090000
- HS Code
- 29350090
- Toxicity
- LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind)
N-Bromosuccinimide Price
- Product number
- 33973
- Product name
- Clorsulon
- Purity
- VETRANAL?, analytical standard
- Packaging
- 100mg
- Price
- $126
- Updated
- 2025/07/31
- Product number
- 1140702
- Product name
- Clorsulon
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $392
- Updated
- 2025/07/31
- Product number
- C3821
- Product name
- Clorsulon
- Packaging
- 100MG
- Price
- $165
- Updated
- 2025/07/31
- Product number
- 30288
- Product name
- Clorsulon
- Packaging
- 50mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 30288
- Product name
- Clorsulon
- Packaging
- 100mg
- Price
- $109
- Updated
- 2024/03/01
Clorsulon Chemical Properties,Usage,Production
Description
Clorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.
Chemical Properties
Crystalline Solid
Uses
analgesic, antiinflammatory
Uses
A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes).
Definition
ChEBI: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a sulfonamide and a member of benzenes.
brand name
Curatrem [Veterinary] (Merial).
Synthesis
60285-85-0
60200-06-8
The general procedure for the synthesis of 4-amino-6-(1,2,2-trichlorovinyl)benzene-1,3-disulfonamide from the compound (CAS: 60285-85-0) is as follows: 100 mL of ethanol and 350 mL of water were mixed and stirred well, then 20 g of ammonia and 2 g of activated carbon were added. The mixture was heated to reflux for 1 hour, followed by thermal filtration. The residue was washed with 50 mL of ethanol and 100 kg of water. The filtrate was slowly cooled to 10 °C, filtered and dried to give 16.5 g of chlorosulfuron in 82.5% yield.
Veterinary Drugs and Treatments
Clorsulon is approved for use in the treatment of immature and adult forms of Fasciola hepatica (Liver fluke) in cattle. It is not effective against immature flukes less than 8 weeks old. It also has activity against Fasciola gigantica. Although not approved, the drug has been used in practice in various other species (e.g., sheep, llamas). It has activity against F. magna in sheep, but is not completely effective in eradicating the organism after a single dose, thus severely limiting its clinical usefulness against this parasite. Clorsulon is also not effective against the rumen fluke (Paramphistomum).
References
[1] Patent: CN104230767, 2016, B. Location in patent: Paragraph 0035; 0036
Clorsulon Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Clorsulon manufacturers
- Product
- Clorsulon 60200-06-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-26
- Product
- Clorsulon 60200-06-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2021-10-21
- Product
- Clorsulon 60200-06-8
- Price
- US $0.00-0.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-08-03