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2-Fluoro-4-nitrotoluene

Product Name
2-Fluoro-4-nitrotoluene
CAS No.
1427-07-2
Chemical Name
2-Fluoro-4-nitrotoluene
Synonyms
2-FLUORO-1-METHYL-4-NITROBENZENE;uoro-4-nitrotoL;2-Fluoro-4-nitrotolu;2-Fluoro-4-nitrotluene;2-fluoro-4-Nitrotoluol;2-fluoro-4-nitrtoluene;2-fluoro-4-nitrobenzene;2-FLUORO-4-NITROTOLUENE;4-Fluoro-4-Nitrotoluene;4-Nitro-2-fluorotoluene
CBNumber
CB8379153
Molecular Formula
C7H6FNO2
Formula Weight
155.13
MOL File
1427-07-2.mol
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2-Fluoro-4-nitrotoluene Property

Melting point:
31-35 °C (lit.)
Boiling point:
65-68 °C/2 mmHg (lit.)
Density 
1.3021 (estimate)
Flash point:
165 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Low Melting Solid
color 
Yellow to brown
Water Solubility 
Insoluble in water. Solubility in methanol gives very faint turbidity.
FreezingPoint 
32.0 to 35.0 ℃
BRN 
2250156
InChI
InChI=1S/C7H6FNO2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,1H3
InChIKey
WIQISTBTOQNVCE-UHFFFAOYSA-N
SMILES
C1(C)=CC=C([N+]([O-])=O)C=C1F
CAS DataBase Reference
1427-07-2(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 2-fluoro-1-methyl-4-nitro-(1427-07-2)
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Safety

Hazard Codes 
Xn,Xi,F
Risk Statements 
20/21/22-36/37/38-11
Safety Statements 
26-36/37/39
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29049085
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
222704
Product name
2-Fluoro-4-nitrotoluene
Purity
98%
Packaging
25g
Price
$133
Updated
2025/07/31
TCI Chemical
Product number
F0292
Product name
2-Fluoro-4-nitrotoluene
Purity
>97.0%(GC)
Packaging
5g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
F0292
Product name
2-Fluoro-4-nitrotoluene
Purity
>97.0%(GC)
Packaging
25g
Price
$75
Updated
2025/07/31
TRC
Product number
F594880
Product name
2-Fluoro-4-nitrotoluene
Packaging
100g
Price
$330
Updated
2021/12/16
TRC
Product number
F594880
Product name
2-Fluoro-4-nitrotoluene
Packaging
250g
Price
$800
Updated
2021/12/16
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2-Fluoro-4-nitrotoluene Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Fluoro-4-nitrotoluene was used in the synthesis of 2-fluoro-4-nitrobenzoic acid.

Synthesis

99-99-0

1427-07-2

General procedure for the synthesis of 2-fluoro-4-nitrotoluene from 4-nitrotoluene: To a three-necked flask equipped with an argon inlet and a thermometer was added a solution of anhydrous acetonitrile (15 mL) of 4-nitrotoluene (10 mmol). Subsequently, bis(trifluoroethoxy)phenyl iodide(III) tetrafluoroborate (BTFE, 2.0 g, 14 mmol) was added. The reaction mixture was cooled to -35 °C under argon protection and xenon difluoride (XeF2, 2.05 g, 12.5 mmol) was added in batches. The mixture was slowly warmed to -25 °C and stirred at this temperature for 30 min, then continued to warm to 20 °C, held for 1 h and stirred for another 1 h (the reaction progress was monitored by gas chromatography). After completion of the reaction, saturated sodium bicarbonate solution was added slowly to the reaction mixture until no gas was produced. The reaction mixture was extracted with ether (3 x 20 mL), the organic phases were combined, washed with water and dried with anhydrous sodium sulfate. For the reaction products of benzene (1), toluene (3) and chlorobenzene (4), the ether extracts were molecularly distilled and fractionated, and the fractions were analyzed by gas chromatography and NMR spectroscopy. For the reaction products of bromobenzene (5), nitrobenzene (6), p-nitrotoluene (7), and p-nitroanisole (8), the ether extracts were concentrated under vacuum at less than 25 °C, and the residue was dissolved in chloroform and separated by fast column chromatography (eluent was hexane-chloroform, 3:1). The eluate was concentrated at atmospheric pressure and the residue was analyzed by NMR spectroscopy. For the reaction product of iodobenzene (15), the precipitate formed after neutralization with sodium bicarbonate solution was filtered, washed with water, and the filtrate was washed sequentially with acetonitrile (5 mL) and ether (5 mL), and the solid was dried in air to give 1.1 g of solid residue, which according to NMR spectroscopy data was a mixture of 76% iodobenzene (16) and 24% (4-iodophenyl)phenyliodonium tetrafluoroborate ( 17) comprising a mixture. The organic filtrate was evaporated and the residue was treated with chloroform to give 100 mg of compound 18 with a melting point of 149 °C (literature value: 147-149 °C).

References

[1] Journal of Fluorine Chemistry, 2000, vol. 102, # 1-2, p. 169 - 173
[2] Russian Chemical Bulletin, 2015, vol. 64, # 5, p. 1049 - 1052
[3] Izv. Akad. Nauk, Ser. Khim., 2015, # 5, p. 1049 - 1052,4

2-Fluoro-4-nitrotoluene Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indazole-3,6-diamine ,97% 2-FLUORO-4-NITROBENZONITRILE 6-nitro-1H-indazol-3-amine
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2-Fluoro-4-nitrotoluene Suppliers

Americas 1 Belgium 4 China 309 Europe 3 France 2 Germany 6 India 12 Italy 1 Japan 2 Jordan 1 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 54 Global 417
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View Lastest Price from 2-Fluoro-4-nitrotoluene manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Fluoro-4-nitrotoluene 1427-07-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1MT
Release date
2025-09-12
Shaanxi Dideu New Materials Co. Ltd
Product
2-Fluoro-4-nitrotoluene 1427-07-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-01
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
2,5-Dimethyl-3-hexyne-2,5-diol 1427-07-2
Price
US $999.00-666.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-09

1427-07-2, 2-Fluoro-4-nitrotolueneRelated Search:

Tribenuron methyl 4-Nitrotoluene 3-Nitrotoluene Methyl salicylate DINITROTOLUENE 2-Nitrotoluene Kresoxim-methyl Thiophanate-methyl Methyl Nitrobenzene Methyl bromide TRITON Fluorine 3-FLUORO-4-NITROTOLUENE,3-Fluoro-4-nitrotoluene 99%,3-Fluoro-4-nitrotoluene, 99+% TERT-BUTYL 2-FLUORO-4-NITROBENZOATE 2-Fluoro-4-nitrobenzotrifluoride 2,5-Difluoro-4-nitrobenzoic acid 2-FLUORO-4-NITROBENZONITRILE

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  • 2-Fluoro-4-nitrotoluene 98%
  • 2-Fluoro-4-nitrotoluene98%
  • 2-Fluoro-4-nitrotluene
  • 2-fluoro-4-nitrobenzene
  • Benzene, 2-fluoro-1-methyl-4-nitro-
  • 1-Methyl-2-fluoro-4-nitrobenzene
  • 1-Nitro-4-methyl-3-fluorobenzene
  • 4-Nitro-2-fluorotoluene
  • 2-Fluoro-4-nitrotolu
  • 3-Fluoro-4-methylnitrobenzene, 2-Fluoro-1-methyl-4-nitrobenzene
  • 2-fluoro-4-Nitrotoluol
  • 2-Fluoro-4-nitrotoluene, 98% 5GR
  • 2-Fluor-1-Methyl-4-nitrobenzol
  • 2-Fluoro-4-nitrotoluene&gt
  • uoro-4-nitrotoL
  • 2-Fluoro-4-nitrotoluene ISO 9001：2015 REACH
  • 2-fluoro-4-nitrtoluene
  • 1427-07-2
  • C7FH6NO2
  • Nitrogen Compounds
  • Organic Building Blocks
  • Nitro Compounds
  • Building Blocks
  • Fluorinated benzene series
  • Nitro Compounds
  • Nitrogen Compounds
  • Organic Building Blocks
  • Halogen toluene
  • Miscellaneous
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • Fluorobenzene
  • Fluorides
  • Fluorin-contained toluene series