ChemicalBook > CAS DataBase List > 2-Amino-5-bromine-2'-chloro benzophenone

2-Amino-5-bromine-2'-chloro benzophenone

Product Name: 2-Amino-5-bromine-2'-chloro benzophenone
CAS No.: 60773-49-1
Chemical Name: 2-Amino-5-bromine-2'-chloro benzophenone
Synonyms: IFLAB-BB F1386-0356;2-Amino-5-Bromine-2-Chloro;5-Bromo-2'-chloro-2-aminobenzophenone;2-Amino-5-bromo-2'-Chlorobenzophenone;2-Amino-5-bromo-2'-Chlorobenzophenone;2-Amino-5-bromine-2'-chlorobenzophenone;2-AMINO-5-BROMINE-2'-CHLORO BENZOPHENONE;Methanone,(2-aMino-5-broMophenyl)(2-chlorophenyl)-;(2-AMINO-5-BROMO-PHENYL)-(2-CHLORO-PHENYL)-METHANONE;(E)-1,5-diphenyl-3-(2-phenylethynyl)-3-pent-1-en-4-ynol
CBNumber: CB8379335
Molecular Formula: C13H9BrClNO
Formula Weight: 310.57
MOL File: 60773-49-1.mol

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2-Amino-5-bromine-2'-chloro benzophenone Property

Melting point:: 85-87°C
Boiling point:: 456.2±40.0 °C(Predicted)
Density: 1.568±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -1.03±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C13H9BrClNO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2
InChIKey: GTLLBGFJGUJABH-UHFFFAOYSA-N
SMILES: C(C1=CC(Br)=CC=C1N)(C1=CC=CC=C1Cl)=O
CAS DataBase Reference: 60773-49-1(CAS DataBase Reference)

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Safety

HS Code: 29223990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A601600
Product name: 2-Amino-5-bromo-2''-chlorobenzophenone
Packaging: 5g
Price: $135
Updated: 2021/12/16

TRC

Product number: A601600
Product name: 2-Amino-5-bromo-2''-chlorobenzophenone
Packaging: 10g
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 001970
Product name: 2-Amino-5-bromo-2'-chlorobenzophenone
Packaging: 1g
Price: $403
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17610
Product name: 2-Amino-5-bromo-2'-chlorobenzophenone
Packaging: 500mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17610
Product name: 2-Amino-5-bromo-2'-chlorobenzophenone
Packaging: 1g
Price: $67.5
Updated: 2021/12/16

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2-Amino-5-bromine-2'-chloro benzophenone Chemical Properties,Usage,Production

Chemical Properties

yellow crystal powder

Uses

Phenazepam metabolite.

Synthesis

609-65-4

106-40-1

60773-49-1

General procedure for the synthesis of 2-amino-5-bromo-2'-chlorobenzophenone from o-chlorobenzoyl chloride and 4-bromoaniline: 1. o-Chlorobenzoyl chloride (177 mL, 1.4 mol) was cooled to 0°C in an ice-water bath in a 2L flask equipped with a condenser and thermometer. 2. 4-Bromoaniline (100 g, 0.58 mol) was added to the cooled solution. 3. The mixture was heated to 120 °C and held at this temperature for 1 hour until complete consumption of 4-bromoaniline was confirmed by TLC analysis (Expanding Agent: EtOAc:Hexane = 1:4). 4. The solution was heated to 160 °C and anhydrous ZnCl2 (95 g, 0.70 mol, pre-flame-dried) was added all at once. 5. Increase the temperature to 195 °C and stir at this temperature for 3 hours until no more bubbles are produced. 6. cooled the mixture to 120 °C and slowly added 12% HCl aqueous solution (350 mL) dropwise. 7. After maintaining reflux for 20 minutes, pour off the aqueous layer. Repeat this process 4 times. 8. Add water (350mL), keep refluxing for 20 minutes and pour out the water. Repeat until solids are no longer lumpy. 9. Add 72% H2SO4 (700mL) to the residue and heat and reflux for approximately 1 hour until the reaction mixture becomes a homogeneous dark colored solution. 10. The hot acidic solution was poured into the ice-water mixture with stirring, and the resulting precipitate was filtered and washed with plenty of cold water until the pH of the solid was about 6. 11. the solid was suspended in ice water, 40% aqueous NaOH solution (290 mL) was carefully added, stirred for 2 hours and the solid was filtered and washed with ice water. 12. Suspend the solid again in ice water, adjust dropwise with 40% H2SO4 to pH ≈ 3, filter the remaining solid and wash with water to neutral. 13. The yellow solid product (66.1 g, 37.0% yield) was dried and used in the next step without further purification. Product characterization: 1H NMR (300MHz, CDCl3) δ 6.49 (s, br, 2H), 6.65 (d, 1H, J=8.82Hz), 7.26-7.8 (m, 6H).

References

[1] Patent: WO2003/82832, 2003, A2. Location in patent: Page/Page column 49; 50-51
[2] Pharmaceutical Chemistry Journal, 1977, vol. 11, # 11, p. 1520 - 1525
[3] Khimiko-Farmatsevticheskii Zhurnal, 1977, vol. 11, # 11, p. 85 - 91

2-Amino-5-bromine-2'-chloro benzophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-5-bromine-2'-chloro benzophenone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Amino-5-bromo-2’-chlorobenzophenone 60773-49-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 50kg/month
Release date: 2021-06-03

Wuhan Boyuan Import & Export Co., LTD

Product: 2-Amino-5-bromine-2'-chloro benzophenone 60773-49-1
Price: US $12.00/mg
Min. Order: 1mg
Purity: 99.96%
Supply Ability: 500ton
Release date: 2023-06-27

Career Henan Chemical Co

Product: 2-Amino-5-bromine-2'-chloro benzophenone 60773-49-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

60773-49-1, 2-Amino-5-bromine-2'-chloro benzophenoneRelated Search:

2-Aminobenzophenone ALTRENOGEST 4-Chlorobenzophenone Glycine 3-Aminophenol Benzophenone 6-Aminocaproic acid 2-Amino-5-chlorobenzophenone Tris(hydroxymethyl)aminomethane 3'-Bromoacetophenone 4-BROMO-2-METHYLANILINE HYDROCHLORIDE 2-AMINO-5-BROMOBENZOPHENONE 1-(2-amino-5-bromophenyl)ethanone 4-BROMO-2-ETHYLANILINE HYDROCHLORIDE Esculetin N-[4-Bromo-2-(2-chlorobenzoyl)phenyl]-2-chloroacetamide Bromine 2-Aminobenzylchloride

2-AMINO-5-BROMINE-2'-CHLORO BENZOPHENONE

(2-AMINO-5-BROMO-PHENYL)-(2-CHLORO-PHENYL)-METHANONE

5-Bromo-2'-chloro-2-aminobenzophenone

2-Amino-5-Bromine-2-Chloro

IFLAB-BB F1386-0356

(E)-1,5-diphenyl-3-(2-phenylethynyl)-3-pent-1-en-4-ynol

Methanone,(2-aMino-5-broMophenyl)(2-chlorophenyl)-

2-Amino-5-bromine-2'-chlorobenzophenone

2-Amino-5-bromo-2'-Chlorobenzophenone

60773-49-1

C13H9NOBrCl

C13H9BrClNO

Aromatic Benzophenones & Derivatives (substituted)

Amines

Aromatics

Metabolites & Impurities