1-(2-Hydroxyethyl)imidazole
- Product Name
- 1-(2-Hydroxyethyl)imidazole
- CAS No.
- 1615-14-1
- Chemical Name
- 1-(2-Hydroxyethyl)imidazole
- Synonyms
- 1H-imidazole-1-ethanol;2-(1-IMIDAZOLYL)ETHANOL;2-iMidazol-1-yl-ethanol;1-HYDROXYETHYL IMIDAZOLE;1-(2-HYDROXYETHYL)IMIDAZOLE;2-(1H-IMidazol-1-yl)ethanol;N-(2-HYDROXYETHYL)-IMIDAZOLE;1-(2-Hydroxyethyl)imidazole,95%;1-(2-Hydroxyethyl)-1H-imidazole;1-(2-Hydroxyethyl)iMidazole 97%
- CBNumber
- CB8381554
- Molecular Formula
- C5H8N2O
- Formula Weight
- 112.13
- MOL File
- 1615-14-1.mol
1-(2-Hydroxyethyl)imidazole Property
- Melting point:
- 36-40 °C (lit.)
- Boiling point:
- 115 °C
- Density
- 1.1524 (rough estimate)
- refractive index
- 1.518-1.52
- Flash point:
- 110 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 13.82±0.10(Predicted)
- Appearance
- White to light yellow <36°C Solid,>40°C Liquid
- InChI
- InChI=1S/C5H8N2O/c8-4-3-7-2-1-6-5-7/h1-2,5,8H,3-4H2
- InChIKey
- AMSDWLOANMAILF-UHFFFAOYSA-N
- SMILES
- C1N(CCO)C=CN=1
- CAS DataBase Reference
- 1615-14-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 576166
- Product name
- 1-(2-Hydroxyethyl)imidazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $67.5
- Updated
- 2025/07/31
- Product number
- I1193
- Product name
- 2-(1H-Imidazol-1-yl)ethanol
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $41
- Updated
- 2025/07/31
- Product number
- I1193
- Product name
- 2-(1H-Imidazol-1-yl)ethanol
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $123
- Updated
- 2025/07/31
- Product number
- H998220
- Product name
- 1-(2-Hydroxyethyl)imidazole
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J94614
- Product name
- 2-(1H-Imidazol-1-yl)ethanol
- Packaging
- 5g
- Price
- $25
- Updated
- 2021/12/16
1-(2-Hydroxyethyl)imidazole Chemical Properties,Usage,Production
Chemical Properties
yellow viscous liquid
Synthesis
17450-34-9
1615-14-1
A solution of anhydrous THF (20 mL) of ethyl 2-(1-imidazolyl)acetate (6.05 g, 39.2 mmol) was added dropwise to a mixture of lithium aluminum hydride (3.00 g, 79.1 mmol) and anhydrous THF (60 mL) at 0 °C under a dry argon atmosphere. The reaction mixture was stirred at 0 °C for 5 minutes, followed by continued stirring at room temperature for 4 hours. Upon completion of the reaction, water (3 mL), 15% aqueous sodium hydroxide solution (3 mL) and water (9 mL) were added sequentially and dropwise at 0 °C to quench the reaction. The resulting mixture was stirred at room temperature for 12 hours and then filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography using chloroform/methanol (10:1, v/v) as eluent. The grades with an Rf value of 0.22 were collected and further purified twice by decompression distillation to finally obtain 1-(2-hydroxyethyl)imidazole (Im2OH) as a colorless oil (2.386 g, 54% yield).
References
[1] Medicinal Chemistry, 2012, vol. 8, # 5, p. 865 - 873
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 10, p. 1991 - 2007
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 6, p. 2604 - 2610
[4] Reactive and Functional Polymers, 2016, vol. 99, p. 1 - 8
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 8, p. 3350 - 3355
1-(2-Hydroxyethyl)imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-Hydroxyethyl)imidazole Suppliers
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- The Netherlands
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View Lastest Price from 1-(2-Hydroxyethyl)imidazole manufacturers
- Product
- 1-(2-Hydroxyethyl)imidazole 1615-14-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-(2-Hydroxyethyl)imidazole 1615-14-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-08