1-(2-Hydroxyethyl)imidazole

Product Name: 1-(2-Hydroxyethyl)imidazole
CAS No.: 1615-14-1
Chemical Name: 1-(2-Hydroxyethyl)imidazole
Synonyms: 1H-imidazole-1-ethanol;2-(1-IMIDAZOLYL)ETHANOL;2-iMidazol-1-yl-ethanol;1-HYDROXYETHYL IMIDAZOLE;1-(2-HYDROXYETHYL)IMIDAZOLE;2-(1H-IMidazol-1-yl)ethanol;N-(2-HYDROXYETHYL)-IMIDAZOLE;1-(2-Hydroxyethyl)imidazole,95%;1-(2-Hydroxyethyl)-1H-imidazole;1-(2-Hydroxyethyl)iMidazole 97%
CBNumber: CB8381554
Molecular Formula: C5H8N2O
Formula Weight: 112.13
MOL File: 1615-14-1.mol

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1-(2-Hydroxyethyl)imidazole Property

Melting point:: 36-40 °C (lit.)
Boiling point:: 115 °C
Density: 1.1524 (rough estimate)
refractive index: 1.518-1.52
Flash point:: 110 °C
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 13.82±0.10(Predicted)
Appearance: White to light yellow <36°C Solid,>40°C Liquid
InChI: InChI=1S/C5H8N2O/c8-4-3-7-2-1-6-5-7/h1-2,5,8H,3-4H2
InChIKey: AMSDWLOANMAILF-UHFFFAOYSA-N
SMILES: C1N(CCO)C=CN=1
CAS DataBase Reference: 1615-14-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 576166
Product name: 1-(2-Hydroxyethyl)imidazole
Purity: 97%
Packaging: 5g
Price: $67.5
Updated: 2025/07/31

TCI Chemical

Product number: I1193
Product name: 2-(1H-Imidazol-1-yl)ethanol
Purity: min. 98.0 %
Packaging: 5G
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: I1193
Product name: 2-(1H-Imidazol-1-yl)ethanol
Purity: min. 98.0 %
Packaging: 25G
Price: $123
Updated: 2025/07/31

TRC

Product number: H998220
Product name: 1-(2-Hydroxyethyl)imidazole
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J94614
Product name: 2-(1H-Imidazol-1-yl)ethanol
Packaging: 5g
Price: $25
Updated: 2021/12/16

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1-(2-Hydroxyethyl)imidazole Chemical Properties,Usage,Production

Chemical Properties

yellow viscous liquid

Synthesis

17450-34-9

1615-14-1

A solution of anhydrous THF (20 mL) of ethyl 2-(1-imidazolyl)acetate (6.05 g, 39.2 mmol) was added dropwise to a mixture of lithium aluminum hydride (3.00 g, 79.1 mmol) and anhydrous THF (60 mL) at 0 °C under a dry argon atmosphere. The reaction mixture was stirred at 0 °C for 5 minutes, followed by continued stirring at room temperature for 4 hours. Upon completion of the reaction, water (3 mL), 15% aqueous sodium hydroxide solution (3 mL) and water (9 mL) were added sequentially and dropwise at 0 °C to quench the reaction. The resulting mixture was stirred at room temperature for 12 hours and then filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography using chloroform/methanol (10:1, v/v) as eluent. The grades with an Rf value of 0.22 were collected and further purified twice by decompression distillation to finally obtain 1-(2-hydroxyethyl)imidazole (Im2OH) as a colorless oil (2.386 g, 54% yield).

References

[1] Medicinal Chemistry, 2012, vol. 8, # 5, p. 865 - 873
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 10, p. 1991 - 2007
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 6, p. 2604 - 2610
[4] Reactive and Functional Polymers, 2016, vol. 99, p. 1 - 8
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 8, p. 3350 - 3355

1-(2-Hydroxyethyl)imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Hydroxyethyl)imidazole Suppliers

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View Lastest Price from 1-(2-Hydroxyethyl)imidazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(2-Hydroxyethyl)imidazole 1615-14-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-(2-Hydroxyethyl)imidazole 1615-14-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-08

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