ChemicalBook > CAS DataBase List > (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Product Name: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
CAS No.: 225920-05-8
Chemical Name: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms: C1oHgOF6;S-MBT-PEL;(S)-1-[3,5-Bis(trifL;Aprepitant Impurity 50;5-Bis(trifluoromethyl)phenyl]ethanol;(S)-3',5'-Bis(trifluoromethyl)-1-phenethanol;(S)-3',5'-Bis(trifluoromethyl)-1-phenethanol;(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;(S)-1-[3,6-Bis(trifluoromethyl)phenyl]ethanol;(S)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol
CBNumber: CB8384616
Molecular Formula: C10H8F6O
Formula Weight: 258.16
MOL File: 225920-05-8.mol

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(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Property

Melting point:: 53.0 to 57.0 °C
Boiling point:: 175.8±35.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 13.99±0.20(Predicted)
color: White to Off-White
λmax: 254nm(lit.)
InChI: InChI=1/C10H8F6O/c1-5(17)6-2-7(9(11,12)13)4-8(3-6)10(14,15)16/h2-5,17H,1H3/t5-/s3
InChIKey: MMSCIQKQJVBPIR-GQMHJJTINA-N
SMILES: C1(C(F)(F)F)C=C(C=C(C(F)(F)F)C=1)[C@@H](O)C |&1:14,r|
CAS DataBase Reference: 225920-05-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
Hazard Note: Irritant
HS Code: 29062990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5244
Product name: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 1g
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: B5244
Product name: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $176
Updated: 2025/07/31

SynQuest Laboratories

Product number: 2802-3-S1
Product name: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: 98%
Packaging: 1g
Price: $32
Updated: 2021/12/16

Ark Pharm

Product number: P000097939
Product name: (S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol
Purity: 96%
Packaging: 25g
Price: $211
Updated: 2021/12/16

Chem-Impex

Product number: 39437
Product name: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 5G
Price: $214.32
Updated: 2021/12/16

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(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Aprepitant intermediate.

Synthesis

30071-93-3

225920-05-8

General procedure: under argon protection, the ruthenium complex Ru(OTf)[(S,S)-iso-BuSO2dpen] (p-cymene) (1.4 mg, 0.002 mmol), potassium formate (1.0 g, 12 mmol), and 3,5-bis(trifluoromethyl)acetophenone (2.56 g, 10 mmol, substrate to catalyst ratio 5000:1) were added to a 20 mL glass Schlenk reaction tube. Subsequently, methanol (6 mL) was added and the reaction was stirred at 50 °C for 24 hours. Upon completion of the reaction, (S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol was obtained in 100% yield with an enantiomeric excess (ee) value of 87.7%.

References

[1] Patent: US2011/282077, 2011, A1. Location in patent: Page/Page column 8
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 32, p. 7329 - 7332
[3] Tetrahedron Asymmetry, 2006, vol. 17, # 4, p. 554 - 559
[4] Patent: CN108059579, 2018, A. Location in patent: Paragraph 0057-0061
[5] Tetrahedron, 2004, vol. 60, # 3, p. 789 - 797

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 225920-05-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Hangzhou ICH Biofarm Co., Ltd

Product: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 225920-05-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ≥1kg
Release date: 2023-07-18

Career Henan Chemical Co

Product: (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 225920-05-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

225920-05-8, (S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanolRelated Search:

PHENYL VALERATE Methyltriphenylphosphonium bromide 2,2,2-TRIFLUOROETHANOL-D3 Trimethylphenylammonium chloride N-Methyldiethanolamine Ethyl acetate Chlorodimethylphenylsilane Phenethyl alcohol 2-Methylaminoethanol PHENYL RESIN 3,3',5,5'-TETRAKIS(TRIFLUOROMETHYL)BENZHYDROL 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol Phenylacetic acid (1R)-1-[3,7-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL,1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL,(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether 2-(3,5-bis(trifluoromethyl)phenyl)ethanol

(S)-1-[3,6-Bis(trifluoromethyl)phenyl]ethanol

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,99%e.e.

(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

(S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL

S-MBT-PEL

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

(1S)-(-)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

Aprepitant Impurity 50

(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethanol

(S)-3,5-Bis(trifluoroMethyl) Phenethyl Alcohol

(S)-(-)-3,5-Bis(trifluoromethyl)-alpha-methylbenzyl alcohol

(S)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol

(S)-1-[3,5-Bis(trifL

Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αS)-

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol

(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ISO 9001：2015 REACH

5-Bis(trifluoromethyl)phenyl]ethanol

(αS)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol

C1oHgOF6

(S)-3',5'-Bis(trifluoromethyl)-1-phenethanol

(alphaS)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanol

225920-05-8

C10H8F6O

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds

API intermediates

Aromatics

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals