Meisoindigo

Product Name: Meisoindigo
CAS No.: 97207-47-1
Chemical Name: Meisoindigo
Synonyms: CS-1454;Natura-α;Dian III;Natura-α;MEISOINDIGO;3'-digallate;Theaflavine-3;Meisoindigo, >96%;Methylisoindigotin;Meisoindigo, >=98%
CBNumber: CB8394558
Molecular Formula: C17H12N2O2
Formula Weight: 276.29
MOL File: 97207-47-1.mol

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Meisoindigo Property

Melting point:: 236-237°C
Boiling point:: 482.0±45.0 °C(Predicted)
Density: 1.381±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
form: powder to crystal
pka: 11.62±0.20(Predicted)
color: Orange to Brown to Dark red

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Safety

HS Code: 2933.79.1500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3082
Product name: Meisoindigo
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $150
Updated: 2024/03/01

TCI Chemical

Product number: M3082
Product name: Meisoindigo
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $410
Updated: 2024/03/01

Cayman Chemical

Product number: 18007
Product name: Meisoindigo
Purity: ≥95%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18007
Product name: Meisoindigo
Purity: ≥95%
Packaging: 1mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 18007
Product name: Meisoindigo
Purity: ≥95%
Packaging: 5mg
Price: $341
Updated: 2024/03/01

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Meisoindigo Chemical Properties,Usage,Production

Description

Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G₀/G₁ phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.

Chemical Properties

mp 236-237°C

Uses

Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy

Uses

Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).

References

[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.

Meisoindigo Preparation Products And Raw materials

Raw materials

Preparation Products

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Meisoindigo Suppliers

Americas 1 China 113 Europe 1 Finland 1 Germany 1 India 2 Japan 1 United States 21 Global 141

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1109
Advantage: 58

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

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View Lastest Price from Meisoindigo manufacturers

Dideu Industries Group Limited

Product: Meisoindigo 97207-47-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: Meisoindigo 97207-47-1
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: Meisoindigo 97207-47-1
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

97207-47-1, MeisoindigoRelated Search:

4-Methyl-2-pentanone Dihydromyrcenol 1-(2,6-Dichlorophenyl)indolin-2-one Basic Violet 1 Methyl tetrahydrophthalic anhydride Methanol Mesotrione Methyl acrylate Acetonitrile cis-Octahydro-isoindole Paraquat dichloride Methylparaben Tetramethylammonium hydroxide Kresoxim-methyl Methyl 2-Butanone Indole Meisoindigo

1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE

3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one

MEISOINDIGO

N-methylisoindigotin

Dian III

Methylisoindigotin

Natura-α

Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one

Methylisoindigotin Meisoindigo

Meisoindigo, >=98%

Meisoindigo, >96%

CS-1454

Meisoindigo(Natura-

DIAN III; N-METHYLISOINDIGOTIN; NATURA-Α

2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-

(3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one

Meisoindigo USP/EP/BP

1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one

Natura-α

3'-digallate

Theaflavine-3

(E)-1-methyl-[3,3'-biindolinylidene]-2,2'-dione

1-Methyl-[3,3'-biindolinylidene]-2,2'-dione

97207-47-1

Inhibitors