Meisoindigo
- Product Name
- Meisoindigo
- CAS No.
- 97207-47-1
- Chemical Name
- Meisoindigo
- Synonyms
- CS-1454;Natura-α;Dian III;Natura-α;MEISOINDIGO;3'-digallate;Theaflavine-3;Meisoindigo, >96%;Methylisoindigotin;Meisoindigo, >=98%
- CBNumber
- CB8394558
- Molecular Formula
- C17H12N2O2
- Formula Weight
- 276.29
- MOL File
- 97207-47-1.mol
Meisoindigo Property
- Melting point:
- 236-237°C
- Boiling point:
- 482.0±45.0 °C(Predicted)
- Density
- 1.381±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
- form
- powder to crystal
- pka
- 11.62±0.20(Predicted)
- color
- Orange to Brown to Dark red
Safety
- HS Code
- 2933.79.1500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M3082
- Product name
- Meisoindigo
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- M3082
- Product name
- Meisoindigo
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $410
- Updated
- 2024/03/01
- Product number
- 18007
- Product name
- Meisoindigo
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18007
- Product name
- Meisoindigo
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 18007
- Product name
- Meisoindigo
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $341
- Updated
- 2024/03/01
Meisoindigo Chemical Properties,Usage,Production
Description
Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.
Chemical Properties
mp 236-237°C
Uses
Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy
Uses
Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).
References
[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.
Meisoindigo Preparation Products And Raw materials
Raw materials
Preparation Products
Meisoindigo Suppliers
View Lastest Price from Meisoindigo manufacturers
- Product
- Meisoindigo 97207-47-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- Meisoindigo 97207-47-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- Meisoindigo 97207-47-1
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03