ChemicalBook > CAS DataBase List > Meisoindigo

Meisoindigo

Product Name
Meisoindigo
CAS No.
97207-47-1
Chemical Name
Meisoindigo
Synonyms
CS-1454;Natura-α;Dian III;MEISOINDIGO;3'-digallate;Theaflavine-3;Meisoindigo, >96%;Methylisoindigotin;Meisoindigo, >=98%;Meisoindigo(Natura-
CBNumber
CB8394558
Molecular Formula
C17H12N2O2
Formula Weight
276.29
MOL File
97207-47-1.mol
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Meisoindigo Property

Melting point:
236-237°C
Boiling point:
482.0±45.0 °C(Predicted)
Density 
1.381±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
form 
powder to crystal
pka
11.62±0.20(Predicted)
color 
Orange to Brown to Dark red
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Safety

HS Code 
2933.79.1500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3082
Product name
Meisoindigo
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
M3082
Product name
Meisoindigo
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$410
Updated
2024/03/01
Cayman Chemical
Product number
18007
Product name
Meisoindigo
Purity
≥95%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18007
Product name
Meisoindigo
Purity
≥95%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
18007
Product name
Meisoindigo
Purity
≥95%
Packaging
5mg
Price
$341
Updated
2024/03/01
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Meisoindigo Chemical Properties,Usage,Production

Description

Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.

Chemical Properties

mp 236-237°C

Uses

Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy

Uses

Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).

References

[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.

Meisoindigo Preparation Products And Raw materials

Raw materials

Preparation Products

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Meisoindigo Suppliers

Americas 1 China 122 Europe 1 Finland 1 Germany 1 India 2 Japan 1 United States 21 Global 150
Shanghai JiYi Biotechnology Co. Ltd.
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Jingmo (Xiamen) Biotechnology Co., Ltd
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TCI (Shanghai) Development Co., Ltd.
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Haoyuan Chemexpress Co., Ltd.
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TargetMol Chemicals Inc.
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View Lastest Price from Meisoindigo manufacturers

Dideu Industries Group Limited
Product
Meisoindigo 97207-47-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Meisoindigo 97207-47-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
800 tons
Release date
2020-04-29
Career Henan Chemical Co
Product
Meisoindigo 97207-47-1
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

97207-47-1, MeisoindigoRelated Search:

4-Methyl-2-pentanone Dihydromyrcenol 1-(2,6-Dichlorophenyl)indolin-2-one Basic Violet 1 Methyl tetrahydrophthalic anhydride Methanol Mesotrione Methyl acrylate Acetonitrile cis-Octahydro-isoindole Paraquat dichloride Methylparaben Tetramethylammonium hydroxide Kresoxim-methyl Methyl 2-Butanone Indole Meisoindigo

  • 1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE
  • 3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one
  • MEISOINDIGO
  • N-methylisoindigotin
  • Dian III
  • Methylisoindigotin
  • Natura-α
  • Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one
  • Methylisoindigotin Meisoindigo
  • Meisoindigo, >=98%
  • Meisoindigo, >96%
  • CS-1454
  • Meisoindigo(Natura-
  • DIAN III; N-METHYLISOINDIGOTIN; NATURA-Α
  • 2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-
  • (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one
  • Meisoindigo USP/EP/BP
  • 1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one
  • 3'-digallate
  • Theaflavine-3
  • (E)-1-methyl-[3,3'-biindolinylidene]-2,2'-dione
  • 1-Methyl-[3,3'-biindolinylidene]-2,2'-dione
  • Meisoindigo, 10 mM in DMSO
  • 97207-47-1
  • Inhibitors