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ChemicalBook > CAS DataBase List > ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER

ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER

Uses
Product Name
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
CAS No.
21085-72-3
Chemical Name
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
Synonyms
(2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate;Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester;Methyl acetobromo-α-D-glucuronate;METHYL ACETOBROMO-ALPHA-D-GLUCURONATE;acetobromo-α-d-glucuronic acid methyl ester;EOS-61715;Acetobromo-aL;Einecs 244-203-4;ucuronicacidmethyL;Methyl α-Acetobromoglucuronate
CBNumber
CB8396406
Molecular Formula
C13H17BrO9
Formula Weight
397.17
MOL File
21085-72-3.mol
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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Property

Melting point:
80-110 °C(lit.)
Boiling point:
388.6±42.0 °C(Predicted)
Density 
1.52
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), Dichlorometha
form 
Crystalline Powder or Solid
color 
White to gray
BRN 
96281
Stability:
Moisture and Temperature Sensitive
InChIKey
BCDVKFMSIQGEHB-CIQUZCHMSA-N
CAS DataBase Reference
21085-72-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25
WGK Germany 
3
3-8-10-21
Hazard Note 
Irritant/Store Cold under -20oC
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8292
Product name
Acetobromo-α-D-glucuronic acid methyl ester
Purity
≥93%
Packaging
1g
Price
$264
Updated
2024/03/01
Sigma-Aldrich
Product number
A8292
Product name
Acetobromo-α-D-glucuronic acid methyl ester
Purity
≥93%
Packaging
5g
Price
$903
Updated
2024/03/01
Usbiological
Product number
A0200-89
Product name
Acetobromo-a-D-glucuronic Acid, Methyl Ester
Packaging
2g
Price
$403
Updated
2021/12/16
TRC
Product number
A162000
Product name
Acetobromo-α-D-glucuronicAcidMethylEster(contains2%CaCO3)
Packaging
5g
Price
$275
Updated
2021/12/16
Biosynth Carbosynth
Product number
MB31644
Product name
1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester
Packaging
5G
Price
$300
Updated
2021/12/16
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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of HMR1098-S-glucuronide methyl ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of water-soluble glucuronide derivatives of Camptothecin, which is used for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of glucuronide prodrug compounds of Janus kinase (JAK) inhibitor tofacitinib, which could be cleaved by β-glucuronidase enzymes such as those produced by the microbiome in the gastrointestinal tract, thereby increasing levels of tofacitinib at the site of gastrointestinal inflammation and limiting the systemic exposure of tofacitinib when treating localized inflammatory diseases.

Chemical Properties

White Crystalline Solid

Uses

Antitumor agent

ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Suppliers

Suzhou Haiheng Biological Pharmaceutical Co., Ltd.
Tel
0512-65045967 15365387483
Fax
15365387483
Email
sales@haihengpharm.com
Country
China
ProdList
94
Advantage
55
Jinan Samuel Pharmaceutical Co., Ltd.
Tel
0531-88821801 15192360884
Fax
0531-88821802
Email
605818151@qq.com
Country
China
ProdList
350
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
604
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9414
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
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View Lastest Price from ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Acetobromo-a-D-glucuronic acid methyl ester 21085-72-3
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-17
Honest Joy Holdings Limited
Product
Acetobromo-alpha-d-glucuronic acid methyl ester 21085-72-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98.4%
Supply Ability
100 tons
Release date
2022-02-18
GlycoPharm.LLC
Product
1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronide methyl ester 21085-72-3
Price
US $0.00/g/bag
Min. Order
25g/bag
Purity
97%HPLC
Supply Ability
MG-KG
Release date
2020-03-16

21085-72-3, ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTERRelated Search:


  • Methyl acetobromo-α-D-glucuronate, Bromo-2,3,4-tri-O-acetyl-α-D-glucopyranuronic acid methyl ester, (2,3,4-Tri-O-acetyl-α-D-glucopyranosyl bromide)uronic acid methyl ester
  • 1-Bromo-1-deoxy-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronic acid methyl ester
  • 2,3,4-Trideoxy-2,3,4-triacetoxy-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
  • 2-O,3-O,4-O-Triacetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
  • 2-O,3-O,4-O-Triacetyl-6-O-methyl-6-C-oxo-1-bromo-1-deoxy-α-D-glucopyranose
  • 2-O,3-O,4-O-Triacetyl-6-O-methyl-6-oxo-α-D-glucopyranosyl bromide
  • 6-O-Methyl-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronosyl bromide
  • Einecs 244-203-4
  • Acetobromo-α-D-glucuronic acid methyl ester ,98%
  • ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
  • Methyl (3S,4R,6R)-3,4,5-tris(acetoxy)-6-bromotetrahydro-2H-pyran-2-carboxylate
  • Methyl 1-bromo-1-deoxy-2,3,4-tri-O-acetyl-alpha-D-glucopyranuronate
  • Methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-alpha-D-glucopyranosyluronate
  • METHYL ACETOBROMO-ALPHA-D-GLUCURONATE
  • BROMO-2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANURONIC ACID METHYL ESTER
  • BROMOMETHYLTRIACETYL GLUCURONATE
  • alpha-d-glucopyranuronicacid,1-bromo-1-deoxy-,methylester,triacetate
  • (2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE)URONIC ACID METHYL ESTER
  • 2,3,4-TRI-O-ACETYL-1-BROMO-1-DEOXY-ALPHA-DGLUCOPYRANOSIDURONIC ACID METHYL ESTER
  • 1-BROMO-1-DEOXY-2,3,4-TRI-0-ACETYL-Α-D-GLUCURONICACID
  • METHYL (2S,3S,4S,5R,6R)-3,4,5-TRIS(ACETYLOXY)-6-BROMOOXANE-2-CARBOXYLATE
  • 1-Bromo-2,3,4-tri-O-acetyl-α-D- glucuronide methyl ester
  • EOS-61715
  • (2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
  • 1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
  • Methyl tri-O-acetyl-1-broMo-1-deoxy-α-D-glucopyranuronate
  • Methyl acetobromo-α-D-glucuronate
  • (2S,3S,4S,5R,6R)-methyl 3,4,5-triacetoxy-6-bromo-tetrahydro-2H-pyran-2-carboxylate
  • (2R,3R,5S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
  • 1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester - 1% CaCO3
  • Acetobromo-α-D-glucuronic Acid Methyl Ester Α-D
  • 1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronic Acid Methyl Ester
  • Methyl a-Acetobromoglucuronate
  • Bromo-2,3,4-tri-O-acetyl-a-d-glucopyranuronic Acid Methyl Ester
  • (2,3,4-tri-o-acetyl-α-d-glucopyranosyl bromide)uronic acid methyl ester
  • acetobromo-α-d-glucuronic acid methyl ester
  • 1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronidemethylester
  • METHYL 2,3,4-TRI-O-ACETYL-1-BROMO-1-DEOXY-A-D-GLUCOPYRANURONATE
  • Acetobromo-alpha-D-glucuronic acid, methyl ester 95+%
  • 1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-ALPHA-D-glucuronide methyl ester
  • Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester
  • Methyl α-Acetobromoglucuronate
  • ACETOBROMO-A-D-GLUCURONIC ACID, METHYL ESTER
  • methyl tri-O-acetyl-1-bromo-1-deoxy-alpha-D-glucopyranuronate
  • 1-BROMO-2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCURONIC ACID METHYL ESTER
  • Acetobromo-aL
  • ucuronicacidmethyL
  • 2,3,4-Tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
  • Methyl 2,3,4-Tri-O-acetyl-alpha-D-glucopyranosyluronate Bromide
  • ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER USP/EP/BP
  • Acetobromo-α-D-glucuronic Acid Methyl Ester (contains 2% CaCO3)
  • methyl tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronate
  • 1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
  • Acetobromo- α-D-glucuronic acid methyl ester
  • 2,3,4-Tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
  • Methyl(tri-O-acetyl-α-D-glucopyranosyl bromide)uronate
  • α-D-Glucopyranuronic acid, 1-bromo-1-deoxy-, methyl ester, 2,3,4-triacetate
  • 1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronic Acid Methyl Ester