ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
Uses- Product Name
- ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
- CAS No.
- 21085-72-3
- Chemical Name
- ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
- Synonyms
- (2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate;Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester;Methyl acetobromo-α-D-glucuronate;METHYL ACETOBROMO-ALPHA-D-GLUCURONATE;acetobromo-α-d-glucuronic acid methyl ester;EOS-61715;Acetobromo-aL;Einecs 244-203-4;ucuronicacidmethyL;Methyl α-Acetobromoglucuronate
- CBNumber
- CB8396406
- Molecular Formula
- C13H17BrO9
- Formula Weight
- 397.17
- MOL File
- 21085-72-3.mol
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Property
- Melting point:
- 80-110 °C(lit.)
- Boiling point:
- 388.6±42.0 °C(Predicted)
- Density
- 1.52
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), Dichlorometha
- form
- Crystalline Powder or Solid
- color
- White to gray
- BRN
- 96281
- Stability:
- Moisture and Temperature Sensitive
- InChIKey
- BCDVKFMSIQGEHB-CIQUZCHMSA-N
- CAS DataBase Reference
- 21085-72-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A8292
- Product name
- Acetobromo-α-D-glucuronic acid methyl ester
- Purity
- ≥93%
- Packaging
- 1g
- Price
- $264
- Updated
- 2024/03/01
- Product number
- A8292
- Product name
- Acetobromo-α-D-glucuronic acid methyl ester
- Purity
- ≥93%
- Packaging
- 5g
- Price
- $903
- Updated
- 2024/03/01
- Product number
- A0200-89
- Product name
- Acetobromo-a-D-glucuronic Acid, Methyl Ester
- Packaging
- 2g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- A162000
- Product name
- Acetobromo-α-D-glucuronicAcidMethylEster(contains2%CaCO3)
- Packaging
- 5g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- MB31644
- Product name
- 1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester
- Packaging
- 5G
- Price
- $300
- Updated
- 2021/12/16
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of HMR1098-S-glucuronide methyl ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of water-soluble glucuronide derivatives of Camptothecin, which is used for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of glucuronide prodrug compounds of Janus kinase (JAK) inhibitor tofacitinib, which could be cleaved by β-glucuronidase enzymes such as those produced by the microbiome in the gastrointestinal tract, thereby increasing levels of tofacitinib at the site of gastrointestinal inflammation and limiting the systemic exposure of tofacitinib when treating localized inflammatory diseases.
Chemical Properties
White Crystalline Solid
Uses
Antitumor agent
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER manufacturers
- Product
- Acetobromo-a-D-glucuronic acid methyl ester 21085-72-3
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-17
- Product
- Acetobromo-alpha-d-glucuronic acid methyl ester 21085-72-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronide methyl ester 21085-72-3
- Price
- US $0.00/g/bag
- Min. Order
- 25g/bag
- Purity
- 97%HPLC
- Supply Ability
- MG-KG
- Release date
- 2020-03-16