ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER

Uses

Product Name: ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
CAS No.: 21085-72-3
Chemical Name: ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
Synonyms: (2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate;Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester;Methyl acetobromo-α-D-glucuronate;METHYL ACETOBROMO-ALPHA-D-GLUCURONATE;acetobromo-α-d-glucuronic acid methyl ester;EOS-61715;Acetobromo-aL;Einecs 244-203-4;ucuronicacidmethyL;Methyl α-Acetobromoglucuronate
CBNumber: CB8396406
Molecular Formula: C13H17BrO9
Formula Weight: 397.17
MOL File: 21085-72-3.mol

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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Property

Melting point:: 80-110 °C(lit.)
Boiling point:: 388.6±42.0 °C(Predicted)
Density: 1.52
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), Dichlorometha
form: Crystalline Powder or Solid
color: White to gray
BRN: 96281
Stability:: Moisture and Temperature Sensitive
InChIKey: BCDVKFMSIQGEHB-CIQUZCHMSA-N
CAS DataBase Reference: 21085-72-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
F: 3-8-10-21
Hazard Note: Irritant/Store Cold under -20oC
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8292
Product name: Acetobromo-α-D-glucuronic acid methyl ester
Purity: ≥93%
Packaging: 1g
Price: $264
Updated: 2024/03/01

Sigma-Aldrich

Product number: A8292
Product name: Acetobromo-α-D-glucuronic acid methyl ester
Purity: ≥93%
Packaging: 5g
Price: $903
Updated: 2024/03/01

Usbiological

Product number: A0200-89
Product name: Acetobromo-a-D-glucuronic Acid, Methyl Ester
Packaging: 2g
Price: $403
Updated: 2021/12/16

TRC

Product number: A162000
Product name: Acetobromo-α-D-glucuronicAcidMethylEster(contains2%CaCO3)
Packaging: 5g
Price: $275
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MB31644
Product name: 1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester
Packaging: 5G
Price: $300
Updated: 2021/12/16

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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of HMR1098-S-glucuronide methyl ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of water-soluble glucuronide derivatives of Camptothecin, which is used for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of glucuronide prodrug compounds of Janus kinase (JAK) inhibitor tofacitinib, which could be cleaved by β-glucuronidase enzymes such as those produced by the microbiome in the gastrointestinal tract, thereby increasing levels of tofacitinib at the site of gastrointestinal inflammation and limiting the systemic exposure of tofacitinib when treating localized inflammatory diseases.

Chemical Properties

White Crystalline Solid

Uses

Antitumor agent

ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Suppliers

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View Lastest Price from ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Acetobromo-a-D-glucuronic acid methyl ester 21085-72-3
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-17

Honest Joy Holdings Limited

Product: Acetobromo-alpha-d-glucuronic acid methyl ester 21085-72-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-02-18

GlycoPharm.LLC

Product: 1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronide methyl ester 21085-72-3
Price: US $0.00/g/bag
Min. Order: 25g/bag
Purity: 97%HPLC
Supply Ability: MG-KG
Release date: 2020-03-16

21085-72-3, ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTERRelated Search:

ETHOXY-IMINO-ACETIC ACID ETHYL ESTER Diethyl ethoxymethylenemalonate Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate ACETOACETIC ACID ISOAMYL ESTER Ethyl glyoxalate 2-[(Acetyloxy)methoxy]ethyl acetate Pinacol vinylboronate 2,3,4,6-Tetra-O-acetyl-alpha-D-glucopyranosyl bromide 2-Bromoethyl acetate 2-(2-Methoxyethoxy)acetic acid 5-Bromopentan-1-ol 1-Bromo-4-methoxybutane 1-BROMO-2-BUTANOL 6-Bromo-1-hexanol 6-Bromohexanoic acid 3-BROMO-1,2-PROPANEDIOL Methyl 6-bromohexanoate D-Glucuronic acid

Methyl acetobromo-α-D-glucuronate, Bromo-2,3,4-tri-O-acetyl-α-D-glucopyranuronic acid methyl ester, (2,3,4-Tri-O-acetyl-α-D-glucopyranosyl bromide)uronic acid methyl ester

1-Bromo-1-deoxy-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronic acid methyl ester

2,3,4-Trideoxy-2,3,4-triacetoxy-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester

2-O,3-O,4-O-Triacetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester

2-O,3-O,4-O-Triacetyl-6-O-methyl-6-C-oxo-1-bromo-1-deoxy-α-D-glucopyranose

2-O,3-O,4-O-Triacetyl-6-O-methyl-6-oxo-α-D-glucopyranosyl bromide

6-O-Methyl-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronosyl bromide

Einecs 244-203-4

Acetobromo-α-D-glucuronic acid methyl ester ,98%

ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER

Methyl (3S,4R,6R)-3,4,5-tris(acetoxy)-6-bromotetrahydro-2H-pyran-2-carboxylate

Methyl 1-bromo-1-deoxy-2,3,4-tri-O-acetyl-alpha-D-glucopyranuronate

Methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-alpha-D-glucopyranosyluronate

METHYL ACETOBROMO-ALPHA-D-GLUCURONATE

BROMO-2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANURONIC ACID METHYL ESTER

BROMOMETHYLTRIACETYL GLUCURONATE

alpha-d-glucopyranuronicacid,1-bromo-1-deoxy-,methylester,triacetate

(2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE)URONIC ACID METHYL ESTER

2,3,4-TRI-O-ACETYL-1-BROMO-1-DEOXY-ALPHA-DGLUCOPYRANOSIDURONIC ACID METHYL ESTER

1-BROMO-1-DEOXY-2,3,4-TRI-0-ACETYL-Α-D-GLUCURONICACID

METHYL (2S,3S,4S,5R,6R)-3,4,5-TRIS(ACETYLOXY)-6-BROMOOXANE-2-CARBOXYLATE

1-Bromo-2,3,4-tri-O-acetyl-α-D- glucuronide methyl ester

EOS-61715

(2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

Methyl tri-O-acetyl-1-broMo-1-deoxy-α-D-glucopyranuronate

Methyl acetobromo-α-D-glucuronate

(2S,3S,4S,5R,6R)-methyl 3,4,5-triacetoxy-6-bromo-tetrahydro-2H-pyran-2-carboxylate

(2R,3R,5S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester - 1% CaCO3

Acetobromo-α-D-glucuronic Acid Methyl Ester Α-D

1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronic Acid Methyl Ester

Methyl a-Acetobromoglucuronate

Bromo-2,3,4-tri-O-acetyl-a-d-glucopyranuronic Acid Methyl Ester

(2,3,4-tri-o-acetyl-α-d-glucopyranosyl bromide)uronic acid methyl ester

acetobromo-α-d-glucuronic acid methyl ester

1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronidemethylester

METHYL 2,3,4-TRI-O-ACETYL-1-BROMO-1-DEOXY-A-D-GLUCOPYRANURONATE

Acetobromo-alpha-D-glucuronic acid, methyl ester 95+%

1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-ALPHA-D-glucuronide methyl ester

Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester

Methyl α-Acetobromoglucuronate

ACETOBROMO-A-D-GLUCURONIC ACID, METHYL ESTER

methyl tri-O-acetyl-1-bromo-1-deoxy-alpha-D-glucopyranuronate

1-BROMO-2,3,4-TRI-O-ACETYL-ALPHA-D-GLUCURONIC ACID METHYL ESTER

Acetobromo-aL

ucuronicacidmethyL

2,3,4-Tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester

Methyl 2,3,4-Tri-O-acetyl-alpha-D-glucopyranosyluronate Bromide

ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER USP/EP/BP

Acetobromo-α-D-glucuronic Acid Methyl Ester (contains 2% CaCO3)

methyl tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronate

1-Bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

Acetobromo- α-D-glucuronic acid methyl ester

2,3,4-Tri-O-acetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester

Methyl(tri-O-acetyl-α-D-glucopyranosyl bromide)uronate

α-D-Glucopyranuronic acid, 1-bromo-1-deoxy-, methyl ester, 2,3,4-triacetate

1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronic Acid Methyl Ester