PRISTANE Property

Melting point:

-99 °C

Boiling point:

68 °C/0.001 mmHg (lit.)

Density 

0.783 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.438(lit.)

Flash point:

110 °C

storage temp. 

Store at -20°C

solubility 

DMSO : 100 mg/mL (372.41 mM; Need ultrasonic)

form 

liquid

color 

Clear colorless

Water Solubility 

0.01ug/L(25 ºC)

Merck 

14,7752

BRN 

1720538

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

EPA Substance Registry System

Pristane (1921-70-6)

Safety

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

RZ1880000

HS Code 

29011000

Hazardous Substances Data

1921-70-6(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

PRISTANE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

Pristane is a hydrocarbon oil adjuvant.

Uses

Pristane has been used as an inflammation-inducing agent, leading to myeloma development in BALB/c strain mice. It has been used as a rheumatoid arthritis-inducing agent in rats.

Uses

Lubricant; transformer oil. Anti-corrosion agent. Biological marker. In experimental systems to induce plasmacytomas; in production of monoclonal antibodies.

Definition

ChEBI: A norterpene that is an acyclic saturated hydrocarbon derived from phytane by loss of its C-16 terminal methyl group.

General Description

Pristane is a natural saturated terpenoid alkane used in research on the pathogenesis of autoimmune diseases such as arthritis and lupus.

Biochem/physiol Actions

Pristane is a hydrocarbon oil adjuvant widely used to induce tumorigenesis in mice and arthritis and lupus nephritis in rats. It works as a adjuvant for monoclonal antibody generation in mouse ascites.

Purification Methods

Purify pristane by shaking it with conc H2SO4 (care, if amount of pristane is too small then it should be diluted with pet ether not Et2O which is quite soluble H2SO4), then H2O (care, as it may heat up in contact with conc H2SO4), dry (MgSO4), evaporate and distil it over Na. [S.rensen & S.rensen Acta Chem Scand 3 939 1949, Beilstein 1 III 570.]