2-Fluoro-4-hydroxybenzoic acid
- Product Name
- 2-Fluoro-4-hydroxybenzoic acid
- CAS No.
- 65145-13-3
- Chemical Name
- 2-Fluoro-4-hydroxybenzoic acid
- Synonyms
- RARECHEM AL BO 0814;4-Carboxy-3-fluorophenol;2-FLUORO-4-HYDROXYBENZOIC ACID;2-Fluoro-4-hydroxybenzoicAcid>Benzoicacid, 2-fluoro-4-hydroxy-
- CBNumber
- CB8415156
- Molecular Formula
- C7H5FO3
- Formula Weight
- 156.11
- MOL File
- 65145-13-3.mol
2-Fluoro-4-hydroxybenzoic acid Property
- Melting point:
- 199-202
- Boiling point:
- 334.6±27.0 °C(Predicted)
- Density
- 1.492±0.06 g/cm3(Predicted)
- storage temp.
- RT, stored under nitrogen
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3?+-.0.10(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 65145-13-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36
- HazardClass
- IRRITANT
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS002815
- Product name
- 2-Fluoro-4-hydroxybenzoic acid
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- F0571
- Product name
- 2-Fluoro-4-hydroxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- F0571
- Product name
- 2-Fluoro-4-hydroxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $177
- Updated
- 2025/07/31
- Product number
- F591645
- Product name
- 2-Fluoro-4-hydroxybenzoic Acid
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- F591645
- Product name
- 2-Fluoro-4-hydroxybenzoic Acid
- Packaging
- 25g
- Price
- $360
- Updated
- 2021/12/16
2-Fluoro-4-hydroxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Uses
2-Fluoro-4-hydroxybenzoic Acid, is a fluorinated building block used for the synthesis of more complex pharmaceutical and biologically active compounds. It is also fluorine substituted 4-hydroxybenzoates, which has been shown to have antioxidant activity.
Synthesis
82380-18-5
65145-13-3
General procedure for the synthesis of 2-fluoro-4-hydroxybenzoic acid from 2-fluoro-4-hydroxybenzonitrile: To a stirred solution of 2-fluoro-4-hydroxybenzonitrile (20.00 g, 145.9 mmol) in 160 mL of water was slowly added an aqueous 50% sodium hydroxide solution (40.00 g, 500.0 mmol). The reaction mixture was heated to reflux for 4 hours and subsequently cooled to room temperature. The cooled mixture was slowly poured into ice-cold concentrated hydrochloric acid and extracted with ether. The aqueous phase was adjusted to alkaline with saturated aqueous sodium bicarbonate, extracted again with ether and the ether layer was discarded. The aqueous phase was acidified with concentrated hydrochloric acid to pH < 2 and then extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2-fluoro-4-hydroxybenzoic acid as a white solid (22.90 g, 100% yield). The product was characterized by 1H NMR (300 MHz, CD3COCD3) and 19F-NMR (300 MHz, CD3COCD3) with the following data: 1H NMR δ (ppm): 9.80 (b, 1H), 7.87 (t, 1H), 6.77 (dd, 1H), 6.66 (dd, 1H); 19F-NMR δ (ppm): -108.13 (s, decoupled).
References
[1] Patent: US2006/20146, 2006, A1. Location in patent: Page/Page column 30
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1981, vol. 67, p. 1 - 24
[3] Patent: US6369261, 2002, B1. Location in patent: Page column 25
2-Fluoro-4-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-4-hydroxybenzoic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 2-Fluoro-4-hydroxybenzoic acid manufacturers
- Product
- 2-Fluoro-4-hydroxybenzoic acid 65145-13-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Fluoro-4-hydroxybenzoic acid 65145-13-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 2-Fluoro-4-hydroxybenzoic acid 65145-13-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-10