4-(Dimethylamino)benzophenone Property

Melting point:

88-90 °C(lit.)

Boiling point:

250 °C / 15mmHg

Density 

1.0463 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder to crystal

pka

2.12±0.12(Predicted)

color 

White to Light yellow to Green

Water Solubility 

insoluble

Merck 

14,3233

InChIKey

BEUGBYXJXMVRFO-UHFFFAOYSA-N

CAS DataBase Reference

530-44-9(CAS DataBase Reference)

NIST Chemistry Reference

Methanone, [4-(dimethylamino)phenyl]phenyl-(530-44-9)

EPA Substance Registry System

Methanone, [4-(dimethylamino)phenyl]phenyl- (530-44-9)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

TSCA 

Yes

HS Code 

29223900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-(Dimethylamino)benzophenone Chemical Properties,Usage,Production

Chemical Properties

YELLOW CRYSTALLINE POWDER OR CRYSTALS

Uses

4-(Dimethylamino)benzophenone is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Synthesis Reference(s)

Synthesis, p. 544, 1986 DOI: 10.1055/s-1986-31696
Tetrahedron Letters, 34, p. 7595, 1993 DOI: 10.1016/S0040-4039(00)60409-4

Purification Methods

Crystallise the pale green p-dimethylaminobenzophenone from EtOH. Dissolve 100g in 600mL of boiling EtOH, add 5g of charcoal, cool, isolate the solid by centrifugation and similarly wash the pale crystals with ice-cold EtOH. When filtered by suction, EtOH solution remains on the crystals and turns deep green in air. Dry it in a vacuum and store it in the dark. The hydrazone has m 128-130o and forms a ketyl with potassium. [Hurd & Webb Org Synth Coll Vol I 217 1941, Beilstein 14 H 82, 14 I 288, 14 III 218, 14 IV 248.]