Vagistat

Product Name: Vagistat
CAS No.: 65899-73-2
Chemical Name: Vagistat
Synonyms: Trosyl;Trosyd;Zoniden;vagistat;UK-20349;Fungibacid;Vagistat 1;ioconazole;Gyno-Trosyd;TIOCONAZOLE
CBNumber: CB8416704
Molecular Formula: C16H13Cl3N2OS
Formula Weight: 387.71
MOL File: 65899-73-2.mol

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Vagistat Property

Melting point:: 79-81oC
Boiling point:: 534.5±50.0 °C(Predicted)
Density: 1.3115 (rough estimate)
refractive index: 1.6000 (estimate)
RTECS: NI4480000
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol.
form: powder
pka: 6.66±0.12(Predicted)
color: white to off-white
CAS DataBase Reference: 65899-73-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2808
Product name: Tioconazole
Packaging: 400MG
Price: $170
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP687
Product name: Tioconazole impurity standard
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP645
Product name: Tioconazole
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $257
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1667439
Product name: Tioconazole
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $157.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 03907
Product name: Tioconazole
Purity: 97%
Packaging: 10g
Price: $183
Updated: 2024/03/01

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Vagistat Chemical Properties,Usage,Production

Description

Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.

Chemical Properties

White powder EINECS: 265-973-8

Originator

Pfizer (United Kiugdom)

Uses

Potent inhibitor of cytochrome-P450

Uses

Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).

Uses

antithrombotic

Definition

ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.

Manufacturing Process

A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C.

brand name

TROSYL

Therapeutic Function

Antifungal

Antimicrobial activity

Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.

Pharmacokinetics

Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.

Clinical Use

1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.

Side effects

Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Vagistat Preparation Products And Raw materials

Raw materials

Preparation Products

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Vagistat Suppliers

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View Lastest Price from Vagistat manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Vagistat 65899-73-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%-101%; EP
Supply Ability: 500kg
Release date: 2021-11-03

Hebei Weibang Biotechnology Co., Ltd

Product: Vagistat 65899-73-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-14

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Vagistat 65899-73-2
Price: US $0.00-0.00/kg
Min. Order: 100kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-05-24

65899-73-2, VagistatRelated Search:

Tioconazole Related Compound A (25 mg) (1-[2,4-Dichloro-beta-[(3-thenyl)-oxy]phenethyl]imidazole hydrochloride) Tioconazole Related CoMpound B Tiotropium-D6 Bromide Morphine Sulfate MORPHINE SULFATE NARCOTIC ANALGESIC 4-Chlorophenethylamine 1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE Vagistat 2-Chlorophenethylamine alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 2-Chloro-3-methylthiophene 3-Thienylmethanol 1-(2-Chlorophenyl)-1-ethanol 2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL MORPHINE SULPHATE - CONTROLLED DRUG (PERMIT REQUIRED) Thiophene Chlorine 2-HYDROXY-2-(2-CHLOROPHENYL)ETHYLAMINE HYDROCHLORIDE

(+-)-1-(2,4-dichloro-beta-((2-chloro-3-ethenyl)oxy)phenethyl)imidazole

1-(2-((2-chloro-3-thienyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazol

vagistat

TIOCONAZOLE

1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole

1H-Imidazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]- (9CI)

Fungibacid

Gyno-Trosyd

New Straitus U

Trosyd

Trosyl

Vagistat 1

Zoniden

1-(1H-Imidazole-1-yl)-2-(2,4-dichlorophenyl)-2-[(2-chloro-3-thienyl)methoxy]ethane

1-[2,4-Dichloro-β-[(2-chloro-3-thenyl)oxy]phenethyl]-1H-imidazole

1-[2,4-Dichloro-β-[(2-chloro-3-thienyl)methyloxy]phenethyl]-1H-imidazole

1-[β-[(2-Chloro-3-thienyl)methoxy]-2,4-dichlorophenethyl]-1H-imidazole

1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole

Tioconazole (200 mg)

TIOCONAZOLE ASSAY STANDARD BP(CRM STANDARD)

TIOCONAZOLE BP STANDARD(CRM STANDARD)

TIOCONAZOLE FOR SYSTEM SUITABILITY EPY(CRM STANDARD)

TIOCONAZOLE USP(CRM STANDARD)

Thioconazole

1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[(2S)-2-[(2-chlorothiophen-3-yl)Methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-iMidazole

UK-20349

Tioconazole, >=99%

ioconazole

Vagistat sulfate

Tioconazole for system suitability CRS

1-[(2RS)-2-[(2-Chlorothiophen-3-yl)methoxy]-2-(2,4- dichlorophenyl)ethyl]-1H-imidazole

1-[(2S)-2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole

1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichl orophenyl)ethyl}-1H-imidazole

Vagistat USP/EP/BP

Tioconazole (UK-20349)

Tioconazole (1667439)

Thiamethoxam health thiazole

tioconazole ,gyno trosyd

65899-73-2

65889-73-2

C16H13Cl3N2OS

AGRYLIN

Antifungal

Active Pharmaceutical Ingredients