Pralidoxime Chloride

Product Name: Pralidoxime Chloride
CAS No.: 51-15-0
Chemical Name: Pralidoxime Chloride
Synonyms: PAM-CL;2-PAM-Cl;protopam;Pyraloxime;PAM CHLORIDE;2-PAM CHLORIDE;protopamchloride;Pyraloxime chloride;PRALIDOXIME CHLORIDE;Pralidoxome Chloride
CBNumber: CB8417130
Molecular Formula: C7H9ClN2O
Formula Weight: 172.61
MOL File: 51-15-0.mol

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Pralidoxime Chloride Property

Melting point:: 230 °C (lit.)
Density: 1.3265 (rough estimate)
refractive index: 1.5430 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Slightly), Water (Sparingly)
form: Solid
pka: pKa 7.8-8 (Uncertain)
color: White to Off-White
Water Solubility: 65.5 g/100 mL (25 ºC)
Merck: 14,7703
BRN: 4163981
CAS DataBase Reference: 51-15-0(CAS DataBase Reference)
EPA Substance Registry System: Pralidoxime chloride (51-15-0)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-20/22
Safety Statements: 36-37/39-26
WGK Germany: 3
RTECS: UU4200000
HS Code: 29333999
Toxicity: LD50 in rats (mg/kg): 96 i.v. (Fleisher); LD50 in rabbits (mg/kg): 95 i.v.; LD50 in mice (mg/kg): 115 i.v., 205 i.p., 4100 orally (Ellin, Wills)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P9053
Product name: Pyridine-2-aldoxime methochloride
Packaging: 5g
Price: $96.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1553000
Product name: Pralidoxime chloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $400
Updated: 2022/05/15

TCI Chemical

Product number: M0819
Product name: 1-Methylpyridinium-2-aldoxime Chloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $104
Updated: 2024/03/01

Alfa Aesar

Product number: B23890
Product name: Pyridine-2-carboxaldoxime methochloride, 97%
Packaging: 5g
Price: $35.65
Updated: 2024/03/01

Alfa Aesar

Product number: B23890
Product name: Pyridine-2-carboxaldoxime methochloride, 97%
Packaging: 25g
Price: $117.65
Updated: 2024/03/01

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Pralidoxime Chloride Chemical Properties,Usage,Production

Chemical Properties

white to off-white adhering crystalline powder

Originator

Contrathion, Specia ,France,1961

Uses

vitamin B6, enzyme cofactor

Uses

This compound binds to inactivated acetylcholinesterases and is used to combat poisoning from organophosphates and nerve agents

Definition

ChEBI: Pralidoxime chloride is a pyridinium salt and an organic chloride salt. It has a role as a cholinesterase reactivator and a cholinergic drug. It contains a pralidoxime.

Manufacturing Process

As described in US Patent 3,123,613, the preparation of the intermediate product, 2-pyridinealdoxime methomethylsulfate, is as follows. 1 kg of 2pyridinealdoxime is dissolved in 6 liters of acetone and filtered until clear. 2 kg (2 equivalents) of freshly distilled dimethyl sulfate are added and the solution mixed. In about 30 minutes crystals start to appear, after which a cooling bath is used to keep the temperature at about 30° to 35°C until the reaction is nearly complete (about 2 hours).
The mixture is allowed to stand at room temperature overnight, the crystals filtered off and washed on a filter with acetone. The product is obtained as colorless needles, which melt at 111° to 112.5°C. The methylsulfate is not stable indefinitely. For preparation of pure chloride salt it is desirable to use methylsulfate which gives no titratable acidity with sodium hydroxide using bromophenol blue as indicator.
10 g of 2-pyridinealdoxime methomethylsulfate are then dissolved in 6 cc of concentrated hydrochloric acid, and 60 cc of isopropanol is added with stirring. Crystals appear almost instantly. After 2 hours standing at room temperature, the crystals are separated by filtration and washed with acetone. The product had a melting point of 227° to 228°C and the yield was 85%.
An alternative route is described in US Patent 3,155,674.
(A) Preparation of 1-Methyl-2-Picolinium Chloride: 98 ml of α-picoline is dissolved in 200 ml of methanol, cooled and 85 ml (at -68°C) of methyl chloride is added. The solution is charged to an autoclave, sealed and the nitrogen pressure of 300 psig is established. The mixture is heated at 120° to 130°C for 2 hours, cooled and opened. The resulting solution is then evaporated to dryness in vacuo, yielding a residue of 110 g. This residue is then dissolved in 50 ml of water and extracted with two 50 ml portions of ether. The aqueous phase is then diluted to 150 ml with water and an assay for ionic chloride is performed which indicates the presence of chloride ion equivalent to 721 mg/ml of l-methyl-2picolinium chloride.
(B) Preparation of 2-(Hydroxyiminomethyl)-1-Methyl Pyridinium Chloride: An aqueous solution of 15 ml of 1-methyl-2-picolinium chloride having a concentration of 477 mg/ml is covered with 50 ml of benzene in an atmosphere of nitrogen and cooled to below 10°C. An aqueous solution of sodium hydroxide is added dropwise and the mixture is stirred for 5 minutes and allowed to stratify. The aqueous phase is then drawn off and the benzenesolution is added slowly to a solution of 3 ml of nitrosyl chloride in 175 ml of benzene containing 0.5 ml of dimethyl formamide at about 10°C in an atmosphere of nitrogen with good agitation. The mixture is then stirred for 1.5 hours and then extracted with four 5 ml of portions of water. The aqueous extracts are then concentrated in vacuo, 30 ml of isopropanol is added and the concentration is repeated. 20 ml of isopropanol is then added to the concentrated mixture, and the mixture is cooled to room temperature and filtered, yielding 3.04 g of crude 2-(hydroxyiminomethyl)-1-methylpyridinium chloride, melting at 202° to 214°C with decomposition. The filtrate is then further concentrated to a 7 g residue which is crystallized from absolute alcohol and yields 0.9 g of 2-(hydroxyiminomethyl)-1-methyl pyridinium chloride melting at 221° to 225°C with decomposition.

brand name

Protopam Chloride (Baxter Healthcare); Protopam Chloride (Wyeth).

Therapeutic Function

Antidote (nerve gas)

General Description

Pralidoxime chloride, 2-formyl-1-methylpyridinium chloride oxime, 2-PAM chloride,or 2-pyridine aldoxime methyl chloride (Protopamchloride), is a white, nonhygroscopic, crystalline powderthat is soluble in water, 1 g in less than 1 mL.

Biochem/physiol Actions

The prototypical reactivator of acetylcholinesterase that has been inactivated by organophosphorus insecticides or nerve agents. It is now known that no reactivator is effective against a broad spectrum of organophosphorus agents.

Clinical Use

Pralidoxime chloride is used as an antidote for poisoningby parathion and related pesticides. It may be effectiveagainst some phosphates that have a quaternary nitrogen. Itis also an effective antagonist for some carbamates, such asneostigmine methylsulfate and pyridostigmine bromide.

Pralidoxime Chloride Preparation Products And Raw materials

Raw materials

2-Picoline weak Ethyl nitrite

Preparation Products

PYRIDINE-2-CARBOXALDOXIME METHIODIDE

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Pralidoxime Chloride Suppliers

Americas 1 Belgium 3 Canada 3 China 214 Czech Republic 1 Europe 3 France 1 Germany 7 India 21 Israel 1 Italy 1 Japan 3 Nigeria 1 Slovakia 1 Switzerland 4 United Kingdom 14 United States 31 Global 310

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View Lastest Price from Pralidoxime Chloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pralidoxime Chloride 51-15-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 50kg/month
Release date: 2023-01-09

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Pyraloxime Methylchloride 51-15-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Pralidoxime Chloride 51-15-0
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-21

51-15-0, Pralidoxime ChlorideRelated Search:

Sodium chloride 2-Chloro-5-chloromethylpyridine 2-Chloro-3-cyanopyridine Calcium chloride Ferric chloride Clopidol Choline chloride Ammonium chloride Chloral hydrate Sulfuryl chloride Polyvinyl chloride Potassium chloride PYRIDINE-2-CARBOXALDOXIME METHIODIDE Atropine Quinine Hydrotalcite FORMALDOXIME HYDROCHLORIDE pyridinium Chlorochromate

1-methyl-2-aldoximinopyridiniumchloride

1-methyl-2-formylpyridiniumchlorideoxime

1-methyl-2-pyridiniumaldoximechloride

2-((hydroxyimino)methyl)-1-methyl-pyridiniuchloride

PYRIDINE-2-ALDOXIME METHOCHLORIDE

PYRIDINE-2-CARBOXALDOXIME METHOCHLORIDE

PYRIDINE-2-CARBALDOXIME METHOCHLORIDE

N-METHYLPYRIDINIUM-2-ALDOXIME CHLORIDE

PAM CHLORIDE

PRALIDOXIME CHLORIDE

2-(hydroxyiminomethyl)-1-methylpyridiniumchloride

2-[(Hydroxyimino)methyl]-1-methylpyridiniumchloride

2-formyl-1-methylpyridiniumchlorideoxime

2-formyl-n-methylpyridiniumoximechloride

2-pyridine-aldoximechloride

2-pyridinealdoximemethylchloride

2-PAM CHLORIDE

2-PYRIDINEALDOXIME METHOCHLORIDE

1-METHYLPYRIDINIUM-2-ALDOXIME CHLORIDE

N-Methylpyridinium-2-carboxaldoxime chloride~2-PAM chloride~Pralidoxime chloride~Pyridine-2-aldoxime methochloride

2-PAM-Cl

Pyridinealdoxime methochloride

N-Methylpyridinium-2-carboxaldoximechloride

PRALIDOXIMECHLORIDE,USP

2-PYRIDINIUMALDOXIMEMETHOCHLORIDE

pyraloxime methylchloride

Pyraloximi Methchlordum

2-Pyridinealdoxime 1-methochloride

2-PYRIDINEALDOXIME METHOCHLORIDE 99%

2-PAM chloride, Pralidoxime chloride

Pralidoxome Chloride

(1-methyl-2-pyridinylidene)methyl-oxoammonium chloride

n-methylpyridiniumchloride2-aldoxime

n-metylpyridinium-2-aldoximechloride

protopam

protopamchloride

pyridinium,2-formyl-1-methyl-,chloride,oxime

pyridiniumaldoximemethochloride

Pvraloximi Chloridum

PAM-CL

Pralidoxime Chloride (200 mg)

2-Pyridinealdoxime methochloride,99%

Pyridine-2-aldoxiMe Meth

Pralidoxime chloride, >=99%

Pyralidoxime Methylchloride

1-Methylpyridinium-2-aldoximeChloride&gt

Pyraloxime chloride

Pyraloxime

Pralidoxime Chloride USP/EP/BP

2-Hydroxyiminomethyl-1-methylpyridiniumchlorid

PraHdoxime Methytchloride

2-PAM chloride (Pyridine-2-aldoxime methochloride)

Pralidoxime Chloride (1553000)

2-((Hydroxyimino)methyl)-1-methylpyridin-1-ium chloride

Pralidoxime chIoride IP/USP

Pralidoxime Chloride-API[PAM.Cl]

51-15-0

C7H9ClN2O