ChemicalBook > CAS DataBase List > H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT

H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT

Product Name
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
CAS No.
23815-89-6
Chemical Name
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
Synonyms
RPPGF;1-5-Bradykinin;BRADYKININ (1-5);ARG-PRO-PRO-GLY-PHE;1-5-Bradykinin (9CI);Arg-Pro-Pro-Gly-Phe-OH;BRADYKININ FRAGMENT 1-5;39: PN: WO0112656 SEQID;H-Arg-Pro-Pro-Gly-Phe-OH;ARG-PRO-PRO-GLY-PHE ACETATE
CBNumber
CB8420710
Molecular Formula
C27H40N8O6
Formula Weight
572.66
MOL File
23815-89-6.mol
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H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Property

Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
pka
3.50±0.10(Predicted)
form 
Solid
color 
White to off-white
Sequence
Arg-Pro-Pro-Gly-Phe
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1401
Product name
Bradykinin Fragment 1-5
Purity
≥97% (HPLC)
Packaging
1mg
Price
$83.3
Updated
2025/07/31
Sigma-Aldrich
Product number
B1401
Product name
Bradykinin Fragment 1-5
Purity
≥97% (HPLC)
Packaging
5mg
Price
$293
Updated
2025/07/31
ChemScene
Product number
CS-0044432
Product name
Bradykinin (1-5)
Purity
≥99.0%
Packaging
1mg
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
32962
Product name
Bradykinin(1-5)trifluoroacetatesalt
Packaging
5MG
Price
$65.23
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB73292
Product name
Bradykinin (1-5)
Packaging
2mg
Price
$85
Updated
2021/12/16
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H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Chemical Properties,Usage,Production

Uses

Biologically active fragment of bradykinin

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

in vivo

Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min[1].

H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Suppliers

China 97 Germany 2 Switzerland 1 United Kingdom 2 United States 15 Global 117
GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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86-21-61263399
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ymbetter@glbiochem.com
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China
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021-54306202 13764082696
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China
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-6206333 13167063860
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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Finetech Industry Limited
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027-87465837 19945049750
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027-8777-2287
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Creative Peptides
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United States
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View Lastest Price from H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT manufacturers

Career Henan Chemical Co
Product
ARG-PRO-PRO-GLY-PHE 23815-89-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

23815-89-6, H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALTRelated Search:

ANGIOTENSIN I/II (4-8) ANGIOTENSIN II, HUMAN H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT H-MET-LYS-ARG-SER-ARG-GLY-PRO-SER-PRO-ARG-ARG-OH Angiotensin acetate ANGIOTENSIN I/II (1-6) ASP-ARG-VAL-TYR (DES-ASP1,ILE8)-ANGIOTENSIN II ANGIOTENSIN I/II (3-7) ABZ-GLY-4-NITRO-PHE-PRO-OH ANGIOTENSIN I/II (1-5) Angiogenin (108-122) TFA BRADYKININ (1-6) H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH ANGIOTENSINOGEN (1-13) (HUMAN) (SAR1,ILE4,8)-ANGIOTENSIN II ANGIOTENSIN III, HUMAN ANGIOTENSIN 1/2 + A (2 - 8)

  • RPPGF
  • ARG-PRO-PRO-GLY-PHE
  • ARG-PRO-PRO-GLY-PHE ACETATE
  • BRADYKININ (1-5)
  • BRADYKININ FRAGMENT 1-5
  • H-ARG-PRO-PRO-GLY-PHE-OH TFA
  • H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
  • H-Arg-Pro-Pro-Gly-Phe-OH
  • Arg-Pro-Pro-Gly-Phe-OH
  • L-Arg-L-Pro-L-Pro-Gly-L-Phe-OH
  • 1-5-Bradykinin
  • 39: PN: WO0112656 SEQID
  • Bradykinin (1-5) trifluoroacetate salt H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt
  • Bradykinin Fragment 1-5, ≥97% (HPLC)
  • N5-(Diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanine
  • 1-5-Bradykinin (9CI)
  • (S)-2-(2-((S)-1-((S)-1-((S)-2-Amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanoic acid
  • Bradykinin Fragment 1-5，TFA
  • 23815-89-6
  • C27H40N8O6
  • Bradykinins
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Peptides
  • Peptide