Description Reference
ChemicalBook > CAS DataBase List > 2'-Hydroxyacetophenone

2'-Hydroxyacetophenone

Description Reference
Product Name
2'-Hydroxyacetophenone
CAS No.
118-93-4
Chemical Name
2'-Hydroxyacetophenone
Synonyms
2-HYDROXYACETOPHENONE;2-HYDROXYACETAMIDE;1-(2-HYDROXYPHENYL)ETHANONE;O-HYDROXYACETOPHENONE;2-ACETYLPHENOL;usafke-20;FEMA 3548;USAF ke-20;AKOS 90575;2-ACETOPHENOL
CBNumber
CB8421762
Molecular Formula
C8H8O2
Formula Weight
136.15
MOL File
118-93-4.mol
More
Less

2'-Hydroxyacetophenone Property

Melting point:
3-6 °C(lit.)
Boiling point:
213 °C717 mm Hg(lit.)
Density 
1.131 g/mL at 25 °C(lit.)
vapor density 
4.7 (vs air)
vapor pressure 
~0.2 mm Hg ( 20 °C)
refractive index 
n20/D 1.558(lit.)
FEMA 
3548 | 2-HYDROXYACETOPHENONE
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
0.2g/l
form 
Liquid
pka
10.06(at 25℃)
color 
Clear yellow to brown
Odor
at 10.00 % in dipropylene glycol. phenolic sweet hawthorn tobacco honey herbal
Odor Type
phenolic
biological source
synthetic
explosive limit
0.98-11.8%(V)
Water Solubility 
slightly soluble
JECFA Number
727
BRN 
386123
LogP
1.92-1.97 at 25℃
Dissociation constant
10.06-10.25 at 20-25℃
CAS DataBase Reference
118-93-4(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(2-hydroxyphenyl)-(118-93-4)
EPA Substance Registry System
2'-Hydroxyacetophenone (118-93-4)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
AM8575000
F 
8
Hazard Note 
Harmful/Irritant
TSCA 
Yes
HS Code 
29145000
Toxicity
LD50 orally in Rabbit: 2127 mg/kg LD50 dermal Rat > 2000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H18607
Product name
2′-Hydroxyacetophenone
Purity
ReagentPlus , 99%
Packaging
5g
Price
$15.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.04310
Product name
2′-Hydroxyacetophenone
Purity
for synthesis
Packaging
250ML
Price
$92.5
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1973
Product name
Acetaminophen Impurity I
Purity
Pharmaceutical Secondary Standards; Certified Reference Material
Packaging
100MG
Price
$388
Updated
2022/05/15
TCI Chemical
Product number
H0192
Product name
2'-Hydroxyacetophenone
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
H0192
Product name
2'-Hydroxyacetophenone
Purity
>98.0%(HPLC)(T)
Packaging
100g
Price
$48
Updated
2024/03/01
More
Less

2'-Hydroxyacetophenone Chemical Properties,Usage,Production

Description

2'-Hydroxyacetophenone is a flavouring ingredient. It is a typical flavour additive for cherry kernel, cinnamon, rum, tobacco, coumarin, and tropical fruit. Moreover, it can be used as the intermediate or raw material in organic synthesis. Specifically, this chemical may act as the raw material to prepare a Schiff's base al-alkoxide initiator that facilitates the controlled polymerization of DL-lactide.1 This substance can also function as the effective component in balsamic compounds for fabricating taste modifying compositions.2 Additionally, this chemical has been employed to react with benzoyl chloride for generating 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran, which exhibits good performance for treating cancer and other proliferative diseases such as psoriasis and restenosis.3

Reference

  1. Bhaw-Luximon, A.; Jhurry, D.; Spassky, N., Controlled polymerization of DL-lactide using a Schiff's base al-alkoxide initiator derived from 2-hydroxyacetophenone. Polym. Bull. 2000, 44, 31-38.
  2. Johann Wonschick; Clemens M. Putter; Keepe, E., TASTE MODIFYING COMPOSITIONS PCT WO 2016/103183 A1 2016.
  3. Alexander J Bridges; Saltiel, A. R., 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders US Patent US5525625 1996.

Chemical Properties

2-Hydroxyacetophenone is a clear yellow to brown liquid that has a sweet, heavy floral, herbaceous odor, reminiscent of mown hay or hawthorn.

Occurrence

Reported found in beef, cassia oil, cocoa, cocoa powder, coffee, Jamaican rum, tomato, Scotch whiskey, sherry, tea, mountain papaya, papaya, roasted almond and black choke berry

Uses

2'-Hydroxyacetophenone is used as pharmaceutical intermediate.

Uses

2’Hydroxyacetophenone is a phenolic compound used in the synthesis of potential anti-myobacterial and anticancer agents.

Definition

ChEBI: 2'-Hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the hydrogens ortho to the acetyl group has been replaced by a hydroxy group. It has a role as a flavouring agent. It is a monohydroxyacetophenone and a member of phenols.

Preparation

Preparation by Fries rearrangement of phenyl acetate, with Lewis acids aluminium chloride.

Aroma threshold values

Detection: 5.5 ppm; aroma characteristics at 2.0%: phenolic, sharp, benzaldehyde, cherry pit, tropical, melon with a tobacco afternote

Taste threshold values

Taste characteristics at 5.0 ppm: naphthyl, cinnamon, cherry pit, coumarin, phenolic, tobacco and honey.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 377, 1983 DOI: 10.1016/S0040-4039(00)81412-4

General Description

2'-Hydroxyacetophenone, also known as O-acetylphenol, belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. 2'-Hydroxyacetophenone is a sweet, hawthorne, and herbal tasting compound. 2'-Hydroxyacetophenone has been detected, but not quantified in, several different foods, such as green tea, arabica coffees (Coffea arabica), chinese cinnamons (Cinnamomum aromaticum), cocoa beans (Theobroma cacao), and cocoa and cocoa products. This could make 2'-hydroxyacetophenone a potential biomarker for the consumption of these foods.

2'-Hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

FLAVANONE 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE 3-METHYLBENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER 4-Hydroxycoumarin Propafenone Hydrochloride 1,2-BENZISOXAZOLE-3-ACETIC ACID 1-(1-2-HYDROXYPHENYL)ETHENYL)-1H-IMIDAZOLE 3-BROMOCHROMONE 3-BROMO-4-HYDROXY-CHROMEN-2-ONE 2'-BENZYLOXYACETOPHENONE 3-(3-AMINOPHENYL)-2H-CHROMEN-2-ONE 3-Methylbenzofuran-2-carboxylic acid 2-Bromo-2′-hydroxyacetophenone 4-BUTYLAMINO-CHROMEN-2-ONE 3-Acetoxybenzofuran 4'-Hydroxyacetophenone 4-AMINO-CHROMEN-2-ONE 3-(4-AMINO-PHENYL)-CHROMEN-2-ONE 3-COUMARANONE 4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE CHROMONE-3-CARBOXALDEHYDE N-(4-HYDROXY-2-OXO-2H-CHROMEN-3-YL)-ACETAMIDE 3-AMINO-4-HYDROXY-CHROMEN-2-ONE
More
Less

2'-Hydroxyacetophenone Suppliers

Americas 1 Belgium 1 Canada 3 China 506 Europe 3 France 2 Germany 7 India 55 Japan 7 Poland 1 Slovakia 1 South Korea 2 Switzerland 3 Ukraine 1 United Kingdom 11 United States 61 Global 665
Shandong Jiu 'an Chemical Industry Co. LTD
Tel
13081423666
Email
276437821@qq.com
Country
China
ProdList
370
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
867
Advantage
58
SINO HIGH(CHINA)CO.,LTD.
Tel
13914336446 15151073745
Email
chang@sinohighchem.com
Country
China
ProdList
30
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com
Country
China
ProdList
613
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Jinxiang Chemical (Danyang) Products Co., Ltd.
Tel
025-86819862 13913839793
Fax
0086-25-86819859
Email
nancyzong@jinchemical.com
Country
China
ProdList
97
Advantage
74
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19183
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8835
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2861
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
4718
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai PE biochem Co.,Ltd.
Tel
+86-21-51762186
Fax
+86-21-51592879
Email
lchinsh@hotmail.com
Country
China
ProdList
94
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
More
Less

View Lastest Price from 2'-Hydroxyacetophenone manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
2'-Hydroxyacetophenone 118-93-4
Price
US $8.80-6.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-07-05
Hebei Weibang Biotechnology Co., Ltd
Product
2'-Hydroxyacetophenone 118-93-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-10-29
Hebei Yanxi Chemical Co., Ltd.
Product
2-Hydroxyacetophenone 118-93-4
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-18

118-93-4, 2'-HydroxyacetophenoneRelated Search:

2-Hydroxyacetophenone,97+%,2-Hydroxyacetophenone,97+% 2-Acetamidophenol ACETAMINOPHEN IMPURITY B 4,4'-Iminodiphenol hydrochloride 4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one 4'-CHLOROACETANILIDE 4'-Hydroxyacetophenone 3-CHLORO-4-HYDROXYACETANILIDE 4-Acetoxyacetanilide N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE Acetanilide 9H-Thioxanthen-9-one, 2-hydroxy- 2-Toluenesulfonyl isocyanate 2-Methylbenzene-1-sulfonamide 2-Chlorophenyl isocyanate 2-Methylphenylacetic acid 2-Methylbenzyl cyanide 2'-Methylacetophenone

  • 1-(2-hydroxyphenyl)-ethanon
  • o-hydroxyphenylmethylketone
  • USAF ke-20
  • usafke-20
  • AKOS 90575
  • AKOS BBS-00003239
  • 2-HYDROXYPHENYL METHYL KETONE
  • 2'-HYDROXYACETOPHENONE
  • 2-HYDROXYACETOPHENONE
  • 2-ACETYLPHENOL
  • 2-ACETOPHENOL
  • FEMA 3548
  • 1-(2-HYDROXYPHENYL)ETHANONE
  • O-HYDROXYACETOPHENONE
  • O-ACETOPHENOL
  • Acetaminophen impurity 9
  • Paracetamol EP Impurity I
  • Acetaminophen Impurity I
  • Paracetamol Impurity 9(Paracetamol EP Impurity I)
  • Acetophenone, o-hydroxy-
  • Ethanone,1-(2-hydroxyphenyl)-
  • o-Acetylphenol
  • o-hydroxy-acetophenon
  • o-Hydroxyphenyl methyl ketone
  • 2'-Hydorxyacetophenone 1-(2-Hydroxyphenyl)ethanone 2-Acetylphenol
  • 2'-HYDROXYACETOPHENONE 98+%
  • 2'-Hydorxyacetophenone
  • 2’-hydroxy-acetophenon
  • 2-hydroxyacetylbenzene
  • Ethanone,1-(2-hydroxypheny
  • 2''-HYDROXYACETOPHENONE 99+%
  • 2-HYDROXYACETAMIDE
  • BENZOYLCARNINOL
  • o-HYDROXYACETOPHENONE pure
  • 2′-Hydroxyacetophenone,2-Acetylphenol
  • 2'-Hydroxyacetopheno
  • 2-Acetophenol 2-Acetylphenol 2-Hydroxyphenyl Methyl Ketone
  • 2'-HYDROXYACETOPHENONE FOR SYNTHESIS
  • 1-(2-Hydroxyphenyl)ethan-1-one, 2-Acetylphenol, 1-(2-Hydroxyphenyl)-1-oxoethane
  • ParacetaMol IMpurity I
  • 2'-Hydroxyacetophenone ReagentPlus(R), 99%
  • 2'-Hydroxyacetophenone Vetec(TM) reagent grade, 98%
  • Acetaminophen Impurity 12
  • 1-(6-hydroxy-1-cyclohexa-2,4-dienyl)ethanone
  • Paracetamol EP Impurity I( 2'-Hydroxyacetophenone)
  • hydroxyacetophenone，o-hydroxyacetophenone
  • 2'-Hydroxyacetophenone, 99%, for synthesis
  • 1-(2-Hydroxyphenyl)ethanone (2-Hydr
  • 2'-Hydroxyacetophenone&gt
  • Paracetamol(Acetaminophen) EP Impurity I
  • Acetaminophen impurities1463
  • Acetaminophen EP Impurity I
  • Paracetamol Impurity I（EP）
  • Potassium 4-methoxysalicylate 152312-71-5
  • 2'-Hydroxyacetophenone
  • Paracetamol EP Impurity I 1-(2-hydroxyphenyl)ethan-1-one
  • Ortho-Hydroxyacetophenone/2'-Hydroxyacetophenone
  • 118-93-4