Sulfapyridine

ChemicalBook > CAS DataBase List > Sulfapyridine

Product Name: Sulfapyridine
CAS No.: 144-83-2
Chemical Name: Sulfapyridine
Synonyms: Sulphapyridine;Sulfapyridin;Ronin;A-499;THAP11;m+b693;Trianon;Adiplon;Dagenan;Eubasin
CBNumber: CB8423160
Molecular Formula: C11H11N3O2S
Formula Weight: 249.29
MOL File: 144-83-2.mol

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Sulfapyridine Property

Melting point:: 191-193°C
Boiling point:: 473.5±51.0 °C(Predicted)
Density: 1.3220 (rough estimate)
refractive index: 1.6740 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: pKa 8.48(H2O t = 25 I = 0.05) (Uncertain)
color: White to Off-White
Water Solubility: <0.1 g/100 mL at 22 ºC
Merck: 14,8938
BRN: 222065
Stability:: Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 144-83-2(CAS DataBase Reference)
NIST Chemistry Reference: Sulfapyridine(144-83-2)
EPA Substance Registry System: Sulfapyridine (144-83-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 2
RTECS: DA9625000
HazardClass: IRRITANT
HS Code: 29350010
Toxicity: LD50 orally in mice: 7.5 mg/g (Wien)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP1039
Product name: Sulfapyridine
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 25MG
Price: $247
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1634000
Product name: Sulfapyridine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $261.6
Updated: 2024/03/01

TCI Chemical

Product number: S0071
Product name: Sulfapyridine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $51
Updated: 2024/03/01

Cayman Chemical

Product number: 28619
Product name: Sulfapyridine
Packaging: 10g
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 28619
Product name: Sulfapyridine
Packaging: 25g
Price: $70
Updated: 2024/03/01

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Sulfapyridine Chemical Properties,Usage,Production

Description

Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities. It is also a metabolite of sulfasalazine formed through bacterial conversion in the colon. It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/ml, respectively), as well as S. aureus (MBC = 0.8 μM). It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS; IC₅₀ = 0.18 μM). Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay. It inhibits histamine release induced by compound 48/80 from isolated rat peritoneal mast cells in a dose-dependent manner. Sulfapyridine (1 μg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.

Chemical Properties

White to Off-White Solid

Uses

Used in treatment of dermatitis herpetiformis; antibacterial.

Uses

antibacterial, dermatitis herpetiformis therapy

Definition

ChEBI: A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.

Antimicrobial activity

Like all sulfanilamides, this drug possesses antibacterial activity with respect to streptococci, pneumococci, staphylococci, meningococci, gonococci, colon bacillus, pathogenic dysentery, and so on. It is a long-lasting drug. Synonyms of this drug are bacillopirin, plurazol, sulfidin, and thiaseptol.

General Description

Sulfapyridine’s plasma half-life is 9 hours.This compound is a white, crystalline, odorless, and tastelesssubstance. It is stable in air but slowly darkens on exposureto light. It is soluble in water (1:3,500), in alcohol(1:440), and in acetone (1:65) at 25°C. It is freely soluble indilute mineral acids and aqueous solutions of sodium andpotassium hydroxide. The pKa is 8.4. Its outstanding effectin curing pneumonia was first recognized by Whitby; however,because of its relatively high toxicity, it has been supplantedlargely by sulfadiazine and sulfamerazine. Severalcases of kidney damage have resulted from acetylsulfapyridinecrystals deposited in the kidneys. It also causes severenausea in most patients. Because of its toxicity, it is usedonly for dermatitis herpetiformis.
Sulfapyridine was the first drug to have an outstandingcurative action on pneumonia. It gave impetus to the studyof the whole class of N¹ heterocyclically substituted derivativesof sulfanilamide.

General Description

Odorless or almost odorless white or yellowish-white crystalline powder. Very slightly bitter taste. Aqueous solution is neutral.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Sulfapyridine is an amino acid. Slowly darkens on exposure to light . Soluble in both acidic and basic aqueous solutions

Fire Hazard

Flash point data for Sulfapyridine are not available; however, Sulfapyridine is probably combustible.

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. Slightly toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and SOx.

Synthesis

Sulfapyridine, N1 -(2-pyridyl)-sulfanilamide (33.1.21), is also synthesized by an analogous scheme from 4-acetylaminobenzenesulfonyl chloride and 2-amino pyridine.

Purification Methods

Crystallise sulfapyridine from 90% acetone and dry it at 90o. Its solubility in Me2CO, EtOH and H2O is 1.5%, 0.22% and 0.02%, respectively. [Winterbottom J Am Chem Soc 62 160 1940, Beilstein 22 III/IV 3978.]

Sulfapyridine Preparation Products And Raw materials

Raw materials

2-Aminopyridine

Preparation Products

Sulfasalazine

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View Lastest Price from Sulfapyridine manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Sulfapyridine 144-83-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Sulfapyridine 144-83-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-02

Hebei Mojin Biotechnology Co., Ltd

Product: Sulfapyridine 144-83-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

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