ChemicalBook > CAS DataBase List > PACOCF3

PACOCF3

Product Name
PACOCF3
CAS No.
141022-99-3
Chemical Name
PACOCF3
Synonyms
PTK;CAKB;FAK2;FADK2;CADTK;PTK2B;RAFTK;PACOCF3;PACOCF?;1,1,1-TRIFLUORO-2-HEPTADECANONE
CBNumber
CB8430016
Molecular Formula
C17H31F3O
Formula Weight
308.42
MOL File
141022-99-3.mol
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PACOCF3 Property

Boiling point:
329.0±37.0 °C(Predicted)
Density 
0.955±0.06 g/cm3(Predicted)
RTECS 
MI3927000
Flash point:
14℃
storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
Liquid
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38-11
Safety Statements 
26-36-16
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P8727
Product name
Palmityl trifluoromethyl ketone
Purity
phosholipase A2 inhibitor
Packaging
5mg
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
506274
Product name
PACOCF?
Purity
A novel Ca
Packaging
5mg
Price
$85.2
Updated
2024/03/01
Sigma-Aldrich
Product number
K3768
Product name
PYK2 (360-690), active, His tagged human
Purity
PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging
10μg
Price
$499
Updated
2023/01/07
Alfa Aesar
Product number
J67117
Product name
Palmityltrifluoromethylketone, 98%
Packaging
50mg
Price
$341
Updated
2021/12/16
Alfa Aesar
Product number
J67117
Product name
Palmityltrifluoromethylketone, 98%
Packaging
10mg
Price
$100
Updated
2021/12/16
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PACOCF3 Chemical Properties,Usage,Production

Description

PTK is an analog of palmitic acid in which the COOH group is replaced by trifluoromethyl ketone. In P388D1 cells, PTK inhibits iPLA2 activity with an IC50 value of 3.8 μM. A related compound, ATK is a less potent inhibitor of iPLA2 with an IC50 value of 15 μM. PTK also inhibits the activity of cPLA2 with an IC50 value almost identical to that of ATK.

Uses

PACOCF3 is an inductors of BLM, an artificial lipid membranes and liposome permeabilization. Phospholipase A2 inhibitor.

Definition

ChEBI: Palmityl Trifluoromethyl Ketone is an alpha-haloketone.

Biological Activity

Phospholipase A 2 inhibitor. Can also alter Ca 2+ signaling in renal tubular cells.

References

1. murakami m et al.emerging roles of secreted phospholipase a2 enzymes: the 3rd edition.biochimie. 2014 sep 16. pii: s0300-9084(14)00252-1.2. quach nd et al. secretory phospholipase a2 enzymes as pharmacological targets for treatment of disease. biochem pharmacol. 2014 aug 15;90(4):338-48. 3. chalimoniuk m. secretory phospholipase a2 and its role in oxidative stress and inflammation]. postepy biochem. 2012;58(2):204-8.4. persaud sj.et al. the role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans. diabetes. 2007 jan;56(1):197-203.5. khakpour h et al. lipoprotein-associated phospholipase a2: an independent predictor of cardiovascular risk and a novel target for immunomodulation therapy. cardiol rev. 2009 sep-oct;17(5):222-9. 6. narendra sharath chandra jn1 et al. chemistry and structural evaluation of different phospholipase a2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity. curr top med chem. 2007;7(8):787-800.7. packard cj. lipoprotein-associated phospholipase a2 as a biomarker of coronary heart disease and a therapeutic target. curr opin cardiol. 2009 jul;24(4):358-63.8. lucas r et al. synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases a2. bioorg med chem lett. 2000 feb 7;10(3):285-8.

PACOCF3 Preparation Products And Raw materials

Raw materials

Preparation Products

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PACOCF3 Suppliers

China 42 Germany 4 Japan 1 Switzerland 2 United Kingdom 2 United States 8 Global 59
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141022-99-3, PACOCF3Related Search:

2-Heptadecanone Citicoline sodium ARISTOLOCHIC ACID SODIUM SALT ISOTETRANDRINE U-73343 Phosphatidylinositol (Soy) SodiuM D609 MAFP 7,7-DIMETHYLEICOSADIENOIC ACID 7-hydroxycoumarinyl-γ-Linolenate MANOALIDE Thioetheramide PC 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID OLEYLOXYETHYL PHOSPHORYLCHOLINE BROMOENOL LACTONE UMBELLIFERYL ARACHIDONATE LUFFARIELLOLIDE PACOCF3

  • 1,1,1-TRIFLUORO-2-HEPTADECANONE
  • 1,1,1-TRIFLUOROHEPTADECANE-2-ONE
  • PALMITYL TRIFLUOROMETHYL KETONE
  • PALMITOYL TRIFLUOROMETHYL KETONE
  • PACOCF3
  • PTK
  • Pentadecyl trifluoromethyl ketone
  • CADTK
  • CAKB
  • FADK2
  • FAK2
  • PTK2B
  • PYK2 (360-690), active, His tagged human
  • RAFTK
  • PACOCF?
  • 1,1,1-trifluoroheptadecan-2-one
  • PACOCF - CAS 141022-99-3 - Calbiochem
  • 2-Heptadecanone, 1,1,1-trifluoro-
  • Palmityl trifluoromethyl ketone phosholipase A2 inhibitor
  • 141022-99-3
  • C17H31F3O
  • Phospholipase A2, Calcium-dependent
  • P to Q
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Biochemicals and Reagents
  • Lipid signaling